| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
To elucidate the mechanism of nonalcoholic steatohepatitis and hepatocellular carcinoma (HCC) caused by excessive intake of fatty acid , we analyzed the mechanism of generation of oxidative stress in obese mice induced by three different types of high fat diet, 1) high trans fatty acid, 2) high oleic acid, or 3) high palmitic acid. A number of HCC was significantly increased in high trans fatty acid fed group compared with other two groups. Further, expression of a factor which related to lipid deposition was significantly higher in the high trans fatty acid diet fed mice. The over expression of the factor by excess trans acid facilitated the accumulation of inflammatory macrophage which express NOX2 and resulted in excessive oxidative stress. On the other hand, liver specific suppression of the factor related to lipid deposition in high trans fatty acid fed mice reduced the number of inflammatory macrophages and the expression of oxidative stress in the liver.
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