• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of molecularly-based signals from food products using LC-MS in foodomics

Research Project

Project/Area Number 15K00879
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionRitsumeikan University

Principal Investigator

Inoue Koichi  立命館大学, 薬学部, 准教授 (30339519)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords食品汚染 / LC-MS / 多変量解析 / 解析・評価 / 栄養学 / 薬学 / 分析科学
Outline of Final Research Achievements

In this study including the field of metabolomics for food defense, the novel evaluation of low-molecular-weight compounds using untargeted LC coupled with electrospray time-of-flight MS and multivariate statistical analysis method is proposed for the quality assessment of the classification, contamination and degradation of food products (infant formula). The LC-MS is used to monitor more detected numbers in food samples. Based on these properties of infant formula, significant differences in the classification of types and origins, the contamination of unknown compound as melamine and the degradations for one week were evaluated based on the PCA patterns. With the metabolomics strategy, the difference from the low-molecular-weight compounds could be utilized for the evaluation of the classification, contamination and degradation of infant formulas for the food safety and quality.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2016 2015

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (2 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Book (2 results)

  • [Journal Article] Analysis of the gut microbiome and plasma short-chain fatty acid profiles in a spontaneous mouse model of metabolic syndrome.2017

    • Author(s)
      Analysis of the gut microbiome and plasma short-chain fatty acid profiles in a spontaneous mouse model of metabolic syndrome.
    • Journal Title

      Sci Rep.

      Volume: 7(1) Issue: 1 Pages: 15876-15876

    • DOI

      10.1038/s41598-017-16189-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Principal component analysis of molecularly-based signals from infant formula contaminations using LC-MS and NMR in foodomics.2016

    • Author(s)
      Inoue, K., Tanada, C., Hosoya, T., Yoshida, S., Akiba, T., Min, J.Z., Todoroki, K., Yamano, Y., Kumazawa, S., Toyo'oka, T.
    • Journal Title

      J. Sci. Food Agric.

      Volume: 96 Issue: 11 Pages: 3876-3881

    • DOI

      10.1002/jsfa.7584

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Metabolomics approach of infant formula for the evaluation of contamination and degradation using hydrophilic interaction liquid chromatography coupled with mass spectrometry.2015

    • Author(s)
      Inoue K, Tanada C, Sakamoto T, Tsutsui H, Akiba T, Min JZ, Todoroki K, Yamano Y, Toyo'oka T.
    • Journal Title

      Food Chem

      Volume: 181 Pages: 318-324

    • DOI

      10.1016/j.foodchem.2015.02.117

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Principal component analysis of molecularly-based signals from infant formula contaminations using LC-MS in foodomics2018

    • Author(s)
      Inoue, K., Nagatomo, R., Tanakda, C., Harada, S.
    • Organizer
      PITTCON 2018 Conference & Expo.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] フードミクスとは?「食の安全から機能性探索までの応用」2015

    • Author(s)
      井之上浩一
    • Organizer
      ifia JAPAN2015
    • Place of Presentation
      東京ビッグサイト(東京・江東区)
    • Year and Date
      2015-05-20
    • Related Report
      2015 Research-status Report
    • Invited
  • [Book] 月刊フードケミカル2016

    • Author(s)
      井之上浩一
    • Total Pages
      118
    • Publisher
      食品化学新聞社
    • Related Report
      2016 Research-status Report
  • [Book] Advanced Mass Spectrometry for Food Safety and Quality 1st Edition2015

    • Author(s)
      Inoue K., Toyo'oka T.
    • Total Pages
      713
    • Publisher
      ELSEVIER
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi