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Prevention of the onset and development of sarcopenia by using a whey protein-derived peptide mixture that suppresses inflammation

Research Project

Project/Area Number 15K00890
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionKanagawa Institute of Technology

Principal Investigator

Sasakio Hajime  神奈川工科大学, 応用バイオ科学部, 教授 (80747634)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsサルコペニア / 乳清たんぱく質 / ペプチド / 骨格筋 / 炎症 / たんぱく質合成 / 炎症抑制 / 抗炎症 / たんぱく質合成促進
Outline of Final Research Achievements

This study was aimed to know if whey protein-derived peptide is effective to prevent sarcopenia. Whey protein-derived peptide intakes suppressed the injury-induced inflammation in the gastrocnemius muscle of mice. Also, whey protein-derived peptide intakes upregulated the mRNA and protein expression of mTOR in the gastrocnemius muscle of mice. These results indicate that whey protein-derived peptide has beneficial properties for a nutritional therapy of sarcopenia. The results obtained by this study suggest that whey protein-derived peptide could be a candidate as a protein source to be utilized in nutrition therapy for patients of sarcopenia.

Academic Significance and Societal Importance of the Research Achievements

高齢者の慢性炎症は、骨格筋のたんぱく質分解系を活性化し筋分解を促進する。そのため、慢性炎症抑制およびたんぱく質合成促進は、サルコペニアの予防・進行抑制のために必要な課題である。乳清たんぱく質は、栄養学的に優れたアミノ酸供給源である。今回の研究で得られた結果(骨格筋の炎症抑制、たんぱく質合成促進)は、乳清たんぱく質(分解ペプチド)が、サルコペニアの栄養療法に機能性たんぱく質としても利用できることを示している。栄養価値の高い乳清たんぱく質にさらにサルコペニアの栄養療法に有効な機能を明らかにした点は、学術的および社会的意義は高いと考えられる。

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2016 2015

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (1 results) (of which Invited: 1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Protective Effect of Ethanolamine on Hepatic Preneoplastic Alterations Induced by the Administration of N-Nitrosodiethylamine in Rats2017

    • Author(s)
      Sasaki H
    • Journal Title

      Food and nutritional sciences

      Volume: 8 Issue: 10 Pages: 936-945

    • DOI

      10.4236/fns.2017.810067

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 32.Increased insulinogenic indexes after liquid food (Inslow) intake in subjects with impaired glucose tolerance and type-2 diabetes: a randomised controlled trial2016

    • Author(s)
      Liu E, Kume A, Yan H, Wang X, Zheng H, Konno T, Ding H, Shen H, Sasaki H, Ji ZS.
    • Journal Title

      Int J Food Sci Nutr Diet

      Volume: 5 Pages: 278-286

    • DOI

      10.19070/2326-3350-1600050

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ホエイペプチド配合免疫調整流動食経口摂取が歯周炎患者における歯肉溝滲出液の炎症性サイトカインに与える影響2015

    • Author(s)
      久保田 健彦, 冨田 尊志, 濃野 要, 阿部 大輔, 清水 太郎, 杉田 典子, 金子 昇, 根津 新, 川島 昭浩, 坪井 洋, 佐々木 一, 吉江 弘正
    • Journal Title

      日本歯科保存学雑誌

      Volume: 58 Issue: 1 Pages: 109-116

    • DOI

      10.1186/s13098-016-0138-4

    • NAID

      130005068919

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oxidation and absorption of glucose and fructose component ingested as a low glycemic sucrose-isomer isomautulose (palatinose) in human2015

    • Author(s)
      Urita Y, Watanabe T, Kawagoe N, Sasaki Y, Ishii T, Tonouchi H, Uchida M, Yamaji T, Sasaki H, Kashimura J, Goto M, Nakajima H, Kaneko H.
    • Journal Title

      Ind J App Res

      Volume: 5 Pages: 406-410

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of nutritional counseling and long term isomaltulose based liquid formula (MHN-01) intake on metabolic syndrome2015

    • Author(s)
      Takeda E, Yamanaka-Okumura H, Taketani Y, Inagaki N, Hosokawa M, Shide K, Maegawa H, Kondo K, Kawasaki E., Shinozaki S, Fujinaka Y, Matsubara T, Katayama T, Sasaki H, Kawashima A, Aonuma H.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 57 Issue: 2 Pages: 140-144

    • DOI

      10.3164/jcbn.14-132

    • NAID

      130005096225

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 品の血糖応答性簡易評価法(GR法)の開発2017

    • Author(s)
      佐々木一
    • Organizer
      日本Glycemic Index研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Patent(Industrial Property Rights)] サルコペニアの予防改善用栄養組成物2018

    • Inventor(s)
      佐々木一
    • Industrial Property Rights Holder
      佐々木一
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-013702
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2020-03-30  

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