Prevention of the onset and development of sarcopenia by using a whey protein-derived peptide mixture that suppresses inflammation
Project/Area Number |
15K00890
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Eating habits
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Research Institution | Kanagawa Institute of Technology |
Principal Investigator |
Sasakio Hajime 神奈川工科大学, 応用バイオ科学部, 教授 (80747634)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | サルコペニア / 乳清たんぱく質 / ペプチド / 骨格筋 / 炎症 / たんぱく質合成 / 炎症抑制 / 抗炎症 / たんぱく質合成促進 |
Outline of Final Research Achievements |
This study was aimed to know if whey protein-derived peptide is effective to prevent sarcopenia. Whey protein-derived peptide intakes suppressed the injury-induced inflammation in the gastrocnemius muscle of mice. Also, whey protein-derived peptide intakes upregulated the mRNA and protein expression of mTOR in the gastrocnemius muscle of mice. These results indicate that whey protein-derived peptide has beneficial properties for a nutritional therapy of sarcopenia. The results obtained by this study suggest that whey protein-derived peptide could be a candidate as a protein source to be utilized in nutrition therapy for patients of sarcopenia.
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Academic Significance and Societal Importance of the Research Achievements |
高齢者の慢性炎症は、骨格筋のたんぱく質分解系を活性化し筋分解を促進する。そのため、慢性炎症抑制およびたんぱく質合成促進は、サルコペニアの予防・進行抑制のために必要な課題である。乳清たんぱく質は、栄養学的に優れたアミノ酸供給源である。今回の研究で得られた結果(骨格筋の炎症抑制、たんぱく質合成促進)は、乳清たんぱく質(分解ペプチド)が、サルコペニアの栄養療法に機能性たんぱく質としても利用できることを示している。栄養価値の高い乳清たんぱく質にさらにサルコペニアの栄養療法に有効な機能を明らかにした点は、学術的および社会的意義は高いと考えられる。
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] ホエイペプチド配合免疫調整流動食経口摂取が歯周炎患者における歯肉溝滲出液の炎症性サイトカインに与える影響2015
Author(s)
久保田 健彦, 冨田 尊志, 濃野 要, 阿部 大輔, 清水 太郎, 杉田 典子, 金子 昇, 根津 新, 川島 昭浩, 坪井 洋, 佐々木 一, 吉江 弘正
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Journal Title
日本歯科保存学雑誌
Volume: 58
Issue: 1
Pages: 109-116
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Oxidation and absorption of glucose and fructose component ingested as a low glycemic sucrose-isomer isomautulose (palatinose) in human2015
Author(s)
Urita Y, Watanabe T, Kawagoe N, Sasaki Y, Ishii T, Tonouchi H, Uchida M, Yamaji T, Sasaki H, Kashimura J, Goto M, Nakajima H, Kaneko H.
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Journal Title
Ind J App Res
Volume: 5
Pages: 406-410
Related Report
Peer Reviewed / Open Access
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[Journal Article] Effect of nutritional counseling and long term isomaltulose based liquid formula (MHN-01) intake on metabolic syndrome2015
Author(s)
Takeda E, Yamanaka-Okumura H, Taketani Y, Inagaki N, Hosokawa M, Shide K, Maegawa H, Kondo K, Kawasaki E., Shinozaki S, Fujinaka Y, Matsubara T, Katayama T, Sasaki H, Kawashima A, Aonuma H.
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Journal Title
Journal of Clinical Biochemistry and Nutrition
Volume: 57
Issue: 2
Pages: 140-144
DOI
NAID
ISSN
0912-0009, 1880-5086
Related Report
Peer Reviewed / Open Access
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