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Evaluation of circadian rhythm and eating behavior by using salivary and urinary biomarkers

Research Project

Project/Area Number 15K00895
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionKyoto Women's University

Principal Investigator

Komenami Naoko  京都女子大学, 家政学部, 准教授 (70291979)

Co-Investigator(Kenkyū-buntansha) 若村 智子  京都大学, 医学研究科, 教授 (40240452)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords唾液 / コルチゾル / バイオマーカー / 非侵襲性 / 食習慣 / 生活習慣 / 高強度運動 / 朝食 / 生体リズム / 唾液バイオマーカー / 尿中バイオマーカー / 唾液sIgA / 唾液コルチゾル / 尿中コルチゾル / 尿中8-OHdG / 運動習慣 / 尿中バイオカーカー / 運動負荷 / 大学生
Outline of Final Research Achievements

This study investigated non-invasive salivary and urinary biomarkers as useful objective indices for monitoring body conditions. Salivary cortisol secretion exhibited typical diurnal rhythm with a peak observed immediately upon awakening that then fell rapidly. Skipping breakfast affected the diurnal rhythm of salivary cortisol secretion. Food composition and moderate exercise did not affect salivary and urinary cortisol secretion. However, urinary 8-OHdG levels significantly increased after carbohydrate ingestion without exercise. In cyclists, significant positive correlations were observed between riding distance and weight loss rate as well as between riding distance and Δ cortisol secretion rate. Hypercatabolism might have been caused by high-intensity exercise that led to weight loss as well as dehydration during riding. Body conditions were successfully evaluated based on circadian rhythm, eating behavior, and exercise by using non-invasive salivary and urinary biomarkers.

Academic Significance and Societal Importance of the Research Achievements

近年、24時間営業の店舗が増え、夜間の活動に伴うライフスタイルの変化や食生活の乱れ、不定愁訴などによる体調不良が指摘されることが多い。健康の維持増進やQOL(生活の質)の向上のためには、個々人の食習慣や生活スタイルを評価し、改善していくことが急務である。そのためには、質問紙による心理的・身体的コンディションの主観的評価に加えて、臨床データなどの客観的指標による評価が重要になる。そこで、非侵襲的に採取可能な唾液および尿中バイオマーカーであるコルチゾルなどを分析することにより、生体リズムおよび食習慣を含む生活スタイルの評価を行って、栄養指導や生活指導に役立つエビデンスを収集することは意義がある。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2018 2017 2016 2015 Other

All Presentation (7 results) (of which Int'l Joint Research: 4 results) Remarks (1 results)

  • [Presentation] Effects of physical exercise and food composition on oxidative stress2018

    • Author(s)
      Yamazaki K. Yamashita K. Komenami N.
    • Organizer
      The 7th Asian Congress of Dietetics
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nutritional Assessment of College Cyclists using Saliva Biomarkers2017

    • Author(s)
      Komenami N.,Yamano Y.,Matsumoto F.,Takemura S.,Yamazaki K.
    • Organizer
      17th International Nutrition & Diagnostics Conference
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 朝食の欠食習慣が唾液バイオマーカーの日内リズムに及ぼす影響2016

    • Author(s)
      坂番和、市田汐里、多谷本朋子、藤井佐紀、竹村理子、松本楓子、若村智子、中山玲子、米浪直子
    • Organizer
      第15回日本栄養改善学会近畿支部学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2016-12-18
    • Related Report
      2016 Research-status Report
  • [Presentation] 運動負荷および食事組成による酸化ストレスへの影響2016

    • Author(s)
      山崎圭世子、山下かえで、松本楓子、竹村理子、坂番和、成田奈保美、米浪直子
    • Organizer
      第71回日本体力医学会大会
    • Place of Presentation
      岩手
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
  • [Presentation] 大学自転車競技選手の栄養アセスメント2015

    • Author(s)
      山野葉子、松本楓子、木口未久、成田奈保美、竹村理子、山崎圭世子、米浪直子
    • Organizer
      第70回日本体力医学会大会
    • Place of Presentation
      和歌山
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Skipping breakfast affects diurnal rhythm of salivary biomarkers in Japanese university students2015

    • Author(s)
      Izumi Sakaban, Tomoko Tayamoto, Shiori Ichida, Tomoko Wakamura, Naoko Komenami
    • Organizer
      12th Asian Congress of Nutrition (ACN)
    • Place of Presentation
      Yokohama
    • Year and Date
      2015-05-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Variation in salivery secretory immunoglobulin A during summer in long-distance runners2015

    • Author(s)
      Kayoko Yamazaki, Rena Takeda, Chiaki Yamashita, Naoko Komenami
    • Organizer
      12th Asian Congress of Nutrition (ACN)
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2015-05-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Remarks] 第17回国際栄養診断学会にて優秀ポスター発表賞(準グランプリ)を受賞しました

    • URL

      http://www.kyoto-wu.ac.jp/gakubu/faculty/shokumotsu/news/n6eaci0000009xgy.html

    • Related Report
      2017 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2020-03-30  

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