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Novel roles of ghrelin and nuromedin U as a modulator of circadian rhythmicity

Research Project

Project/Area Number 15K00901
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionKurume University

Principal Investigator

Tajiri Yuji  久留米大学, 医学部, 准教授 (80469361)

Co-Investigator(Kenkyū-buntansha) 山田 研太郎  久留米大学, 医学部, 教授 (10191305)
御船 弘治  久留米大学, 医学部, 准教授 (70174117)
Co-Investigator(Renkei-kenkyūsha) KOJIMA MASAYASU  久留米大学, 分子生命科学研究所, 教授 (20202062)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords食行動異常 / 肥満モデルマウス / 高脂肪食負荷 / 時計遺伝子 / グレリン / ニューロメジン / 体内時計遺伝子 / 概日リズム / リセット機構 / 食行動
Outline of Final Research Achievements

Circadian rhythmicity based on biological clock is entrained by food or exercise other than light stimulation. In obese model, such an entrainment is thought to be disrupted leading to abnormal feeding behavior. Rhythmicities of plasma ghrelin concentration and neuromedin U (NMU) expression in the hypothalamus are completely inversed in obesity model mice. In NMU knockout mice, voluntary exercise and exploring activity at the end of dark period were significantly decreased compared to those in WT mice. Furthermore, disrupted rhythms of clock genes were observed in obese model. Taken together, it was demonstrated that abnormal feeding behavior observed in obese model could be attributable to disrupted rhythm of either appetite regulating hormones or clock genes.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2017 2015

All Presentation (7 results) (of which Int'l Joint Research: 3 results)

  • [Presentation] Voluntary exercise can modify the preference for palatable food through the modulation of central reward circuit by peripheral ghrelin signal2017

    • Author(s)
      Tajiri Y., Sakai Y., Kawahara Y., Nishi A., Kojima M., Mifune H
    • Organizer
      53rd Annual Meeting of the European Association for the Study of Diabetes
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ghrelin regulates the motivation for voluntary exercise under the control of circadian rhythmicity in mice2017

    • Author(s)
      Mifune H., Tajiri Y., Sakai Y., Sato T., Kojima M
    • Organizer
      53rd Annual Meeting of the European Association for the Study of Diabetes
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] グレリンのドーパミン報酬系を介した自発運動の動機付けについて2017

    • Author(s)
      1.御船弘治,坂井勇介,河原幸江,原 健人,田尻祐司,児島将康
    • Organizer
      第90回日本内分泌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 概日リズムの自発運動発現機構におけるグレリンの役割2017

    • Author(s)
      2.御船弘治,坂井勇介,佐藤貴弘,田尻祐司,角間辰之,児島将康
    • Organizer
      第38回日本肥満学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] グレリン遺伝子欠損マウスに見られる自発運動の異常について2017

    • Author(s)
      3.佐藤貴弘,坂井勇介,田尻祐司,角間辰之,児島将康,御船弘治
    • Organizer
      第24回日本時間生物学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A disrupted rhythm of appetite-regulating hormone is relevant to abnormal feeding behavior in high fat diet induced obese mice2015

    • Author(s)
      Hiroharu Mifune, Yuji Tajiri, Kento Hara, Shimpei Iwata, Yoshihiro Nishi, Masayasu Kojima, Kentaro Yamada
    • Organizer
      51th EASD Annual Meeting
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2015-09-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 肥満モデルマウスの食リズム異常における時計遺伝子発現の関与2015

    • Author(s)
      坂井 勇介, 原 健人, 岩田 慎平, 西 芳寛, 田尻 祐司, 児島 将康, 御船 弘治
    • Organizer
      第2回時間栄養科学研究会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-02
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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