Amelioration of diabetes mellitus by Japanese Apricot (Prunus mume) extract

• Project/Area Number: 15K00902
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: LI Yun-Shan 産業医科大学, 産業生態科学研究所, 講師 (90449950)
• Co-Investigator(Kenkyū-buntansha): 川崎 祐也 産業医科大学, 産業生態科学研究所, 助教 (30721716) ; 葛西 宏 産業医科大学, 産業生態科学研究所, 名誉教授 (40152615) ; 河井 一明 産業医科大学, 産業生態科学研究所, 教授 (60161262)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
• Keywords: 糖尿病 / 酸化ストレス / 8-hydroxydeoxyguanosin

Outline of Final Research Achievements

In this study, improvement effects and active components of extracts of Prunus mume concentration and Fructus mume on diabetes mellitus was studied. The water extract of Prunus mume concentration exhibited strong antioxidant activities and hypoglycemic action in in vivo experiments. On the other hand, higher antioxidant activities and hypoglycemic action of the 80% ethanol extract of Fructus mume carbon were observed. Moreover, the active fractions which provided antioxidant activities and α-glucosidase inhibitory activity of the water extract of Prunus mume concentration and Fructus mume carbon were fractionated by the high performance liquid chromatography (HPLC).

Research Products

• [Presentation] Antioxidant activities of Fructus Mume and plum concentrate (2017)
  • Author(s): Yun-Shan Li, Yuya Kawasaki, Yuko Ootsuyama, Hiroshi Kasai, Kazuaki Kawai
  • Organizer: the 8th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia) & The 14th Conference of the Asian Society of Mitochondrial Research and Medicine (ASMRM)
  • Int'l Joint Research
• [Presentation] ウバイ（烏梅）の抗酸化作用 (2016)
  • Author(s): 李云善、川﨑祐也、大津山祐子、葛西宏、河井一明
  • Organizer: 第45回日本環境変異原学会
  • Place of Presentation: つくば国際会議場（茨城県つくば市）
  • Year and Date: 2016-11-17