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Analysis of reproductive dysfunction induced by asynchrony between daily life and dietary life rhythm in post-adolescent stage

Research Project

Project/Area Number 15K00903
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionKyoto Notre Dame University

Principal Investigator

FUJIWARA Tomoko  京都ノートルダム女子大学, 現代人間学部, 教授 (60310744)

Co-Investigator(Kenkyū-buntansha) 中田 理恵子  奈良女子大学, 生活環境科学系, 准教授 (90198119)
藤原 浩  金沢大学, 医学系, 教授 (30252456)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsポスト思春期 / 生殖機能 / 摂食リズム / ダイエット / 食育プログラム / カロリー制限 / 妊孕性 / 卵巣機能 / 食事リズム / 月経痛
Outline of Final Research Achievements

To investigate relationship between reproductive function and dietary habits, we conducted the questionnaire survey for female college students corresponding to “post-adolescent stage” when the sexual maturation proceeds after menarche. The results showed that skipping breakfast is associated with dysmenorrhea and irregular menses. Consequently, to further confirm the adverse effects of the inadequate timing of food intake during circadian rhythmus on reproductive function, we additionally performed animal experiments using young adult female rats, and found that estrus cycle was disturbed when food intake was strictly limited to the non-active period (light phase). These results strongly suggest that the timing of food intake during circadian rhythmus is one of important factors that regulate female reproductive function. Our findings will also contribute to developing a new dietary education program to reduce the adverse effects on reproductive functions in young women.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2018 2017 2016 2015

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (6 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] 将来の妊孕性確保を目指した女子大学生への食教育2018

    • Author(s)
      藤原智子
    • Journal Title

      CAMPUS HEALTH

      Volume: 55(2)

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary Habits Affecting Reproductive Functions in Young Women2017

    • Author(s)
      Tomoko Fujiwara
    • Journal Title

      Reproductive System and Sexual Disorder International Journal

      Volume: 1(2)

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 食生活と性機能2016

    • Author(s)
      藤原 智子
    • Journal Title

      臨床産婦人科

      Volume: 第70巻第6号 Pages: 533-539

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Smartphone usage during meals is a potential risk for weight gain in post-adolescent female students2016

    • Author(s)
      Tomoko Fujiwara, Rieko Nakata
    • Journal Title

      Integrative Food, Nutrition and Metabolism

      Volume: 3(5) Issue: 5 Pages: 424-426

    • DOI

      10.15761/ifnm.1000162

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Food restriction against daily circadian rhythm affects the post-diet recovery of hypothalmic function in the young female rats2017

    • Author(s)
      Tomoko Fujiwara, Rieko Nakata, Hiroshi Fujiwara
    • Organizer
      BIT's 5th International Congress of Gynaecology and Obstetrics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Timing of diet during daily circadian rhythm affects the post-diet recovery of hypothalmic function in the young female rats2017

    • Author(s)
      Tomoko Fujiwara, Yu Kondo, Rieko Nakata
    • Organizer
      The 19th Biennial International ARAHE Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 過度に痩せているポスト思春期の女性は月経痛を有する2016

    • Author(s)
      藤原 智子、山岸 郁乃、中田 理恵子
    • Organizer
      日本家政学会第68回大会
    • Place of Presentation
      金城学院大学(愛知県・名古屋市)
    • Year and Date
      2016-05-28
    • Related Report
      2016 Research-status Report
  • [Presentation] 活動期に対応したラットの摂食行動はカロリー制限による卵巣機能抑制の新たな制御因子か?2016

    • Author(s)
      藤原 智子、山岸 郁乃、井上 裕康、中田 理恵子、藤原 浩
    • Organizer
      日本栄養・食糧学会第70回大会
    • Place of Presentation
      武庫川女子大学(兵庫県・西宮市)
    • Year and Date
      2016-05-15
    • Related Report
      2016 Research-status Report
  • [Presentation] 長時間のスマートフォンの利用は若年女性の食事摂取認識力を低下させる可能性がある2015

    • Author(s)
      藤原 智子、山岸 郁乃、中田 理恵子
    • Organizer
      日本調理科学会平成27年度大会
    • Place of Presentation
      静岡県立大学(静岡県・静岡市)
    • Year and Date
      2015-08-25
    • Related Report
      2015 Research-status Report
  • [Presentation] Diet during active phase impairs reproductive function in post-adolescent female rats2015

    • Author(s)
      Tomoko Fujiwara,Fumino Yamagishi,Akane Matsumoto,Rieko Nakata
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      PacificoYokohama(神奈川県・横浜市)
    • Year and Date
      2015-05-16
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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