| Project/Area Number |
15K01275
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | National Center of Neurology and Psychiatry (2016-2017)
The University of Tokyo (2015) |
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Principal Investigator |
Watanabe Satoshi 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 微細構造研究部, 流動研究員 (80302610)
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| Co-Investigator(Renkei-kenkyūsha) |
TORIMITSU Keiichi 東北大学, 大学院工学研究科, 教授 (00393728)
KAWAHARA Shigenori 富山大学, 大学院理工学研究部(工学), 教授 (10204752)
HIRONO Moritoshi 同志社大学, 研究開発推進機構, 准教授 (30318836)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 導電性高分子 / 電気生理学 / シナプス伝達 / 脳波 / 瞬目反射 / 小脳 / 条件付け / シナプス可塑性 / 神経修飾物質 / シナプス電位 |
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| Outline of Final Research Achievements |
Long-term recording of brain activity and stimulation are required for diagnosis of diseases and restoration of body functions through brain-machine interface. Poly(3,4-ethylenedioxythiphene) (PEDOT) based organic electrodes have high biocompatibility, but their electrical characteristics have been mostly insufficient for application to the brain. We fabricated an improved fiber electrode using PEDOT doped with p-toluene sulfonate (PEDOT-pTS). Using this electrode, we succeeded in recording neural activity or locally stimulating neurons to induce synaptic transmission.
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