Development of organic fiber electrodes for improving brain functions

• Project/Area Number: 15K01275
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: National Center of Neurology and Psychiatry (2016-2017); The University of Tokyo (2015)
• Principal Investigator: Watanabe Satoshi 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 微細構造研究部, 流動研究員 (80302610)
• Co-Investigator(Renkei-kenkyūsha): TORIMITSU Keiichi 東北大学, 大学院工学研究科, 教授 (00393728) ; KAWAHARA Shigenori 富山大学, 大学院理工学研究部(工学), 教授 (10204752) ; HIRONO Moritoshi 同志社大学, 研究開発推進機構, 准教授 (30318836)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 導電性高分子 / 電気生理学 / シナプス伝達 / 脳波 / 瞬目反射 / 小脳 / 条件付け / シナプス可塑性 / 神経修飾物質 / シナプス電位

Outline of Final Research Achievements

Long-term recording of brain activity and stimulation are required for diagnosis of diseases and restoration of body functions through brain-machine interface. Poly(3,4-ethylenedioxythiphene) (PEDOT) based organic electrodes have high biocompatibility, but their electrical characteristics have been mostly insufficient for application to the brain. We fabricated an improved fiber electrode using PEDOT doped with p-toluene sulfonate (PEDOT-pTS). Using this electrode, we succeeded in recording neural activity or locally stimulating neurons to induce synaptic transmission.

Research Products

• [Journal Article] Novel method of extracting motion from natural movies (2017)
  • Author(s): Suzuki Wataru、Ichinohe Noritaka、Tani Toshiki、Hayami Taku、Miyakawa Naohisa、Watanabe Satoshi、Takeichi Hiroshige
  • Journal Title: Journal of Neuroscience Methods Volume: 291 Pages: 51-60
  • DOI: 10.1016/j.jneumeth.2017.08.006
  • Peer Reviewed / Open Access
• [Journal Article] Electroconductive polymer-coated silk fiber electrodes for neural recording and stimulation in vivo (2017)
  • Author(s): Watababe, S., Takahashi, H., Torimitsu, K.
  • Journal Title: Japanese Journal of Applied Physics Volume: 56 Issue: 3 Pages: 037001-037001
  • DOI: 10.7567/jjap.56.037001
  • NAID: 210000147490
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Phase-dependent modulation of oscillatory phase and synchrony by long-lasting depolarizing inputs in central neurons (2016)
  • Author(s): Watanabe, S., Hirono, M.
  • Journal Title: eNeuro Volume: 3 Issue: 5 Pages: 1-15
  • DOI: 10.1523/eneuro.0066-16.2016
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Perineuronal nets in the deep cerebellar nuclei regulate GABAergic synaptic transmission and delay eyeblink conditioning (2017)
  • Author(s): Hirono, M., Watanabe, S., Kawahara, S., Nagao, S., Yanagawa, Y., Misonou, H.
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: アクトシティ浜松（静岡県浜松市）
  • Year and Date: 2017-03-28
• [Presentation] 小脳核ニューロンのペリニューロナルネットによるGABAシナプス伝達修飾と瞬目反射条件づけ制御 (2017)
  • Author(s): 廣野 守俊、渡辺 恵、川原 茂敬、永雄 総一、柳川 右千夫、御園生 裕明
  • Organizer: 第40回日本神経科学大会
• [Presentation] Phase-dependent modulation of neural oscillations by synaptic inputs (2016)
  • Author(s): Watanabe, S., Hirono, M.
  • Organizer: 日本生物物理学会第54回年会
  • Place of Presentation: つくば国際会議場（茨城県つくば市）
  • Year and Date: 2016-11-25
• [Presentation] Conductive silk electrode for intra/extra bioelectrical measurement (2016)
  • Author(s): Torimitsu, K, Takizawa, Y., Takahashi, H., Watanabe, S., Sonobe, T.
  • Organizer: 38th Annual International Conference of the IEEE Engineering in Medicine and Biology
  • Place of Presentation: Contemporary Resort, Orlando, FL, USA
  • Year and Date: 2016-08-17
  • Int'l Joint Research
• [Presentation] Phase-dependent effects of synaptic inputs on neural oscillations (2016)
  • Author(s): Watanabe, S., Hirono, M.
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-07-20
• [Presentation] 振動活動に対するシナプス入力の位相依存性効果 (2016)
  • Author(s): 渡邉 惠，廣野 守俊
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-07-20
• [Presentation] 神経細胞周囲網による小脳核抑制性GABA シナプス伝達の制御 (2016)
  • Author(s): 廣野 守俊，渡邉 惠，川原 茂敬，永雄 総一，柳川 右千夫，御園生 裕明
  • Organizer: 第93回日本生理学会大会
  • Place of Presentation: 札幌コンベンションセンター（北海道札幌市）
  • Year and Date: 2016-03-22
• [Presentation] 柔らかい有機電極を用いる脳活動の同時多点測定 (2015)
  • Author(s): 渡邉 惠，高橋 秀幸，鳥光 慶一
  • Organizer: 日本生物物理学会第53回年会
  • Place of Presentation: 金沢大学（石川県金沢市）
  • Year and Date: 2015-09-13
• [Presentation] 生体活動電位モニタリング用シルク電極の開発 (2015)
  • Author(s): 瀧澤 勇介，園部 達真，高橋 秀幸，渡邉 惠，西澤 松彦，鳥光 慶一
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-07-28
• [Presentation] Developmental chick neuronal activity measurement using silk flexible electrode (2015)
  • Author(s): Torimitsu, K., Sonobe, T., Takizawa, Y., Takahashi, H., Watanabe, S.
  • Organizer: 1st Congress of the European Academy of Neurology
  • Place of Presentation: ベルリン（ドイツ）
  • Year and Date: 2015-06-20
  • Int'l Joint Research