Establishing elemental technologies of high-sensitive MRI for molecular imaging

• Project/Area Number: 15K01283
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Kyoto University
• Principal Investigator: IMAI Hirohiko 京都大学, 情報学研究科, 助教 (40506466)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 磁気共鳴イメージング / 核磁気共鳴 / 分子イメージング / 化学交換飽和移動 / 超偏極

Outline of Final Research Achievements

We studied on several techniques related to a CEST MRI in order to develop a high-sensitive MRI method for molecular imaging. We have demonstrated that a neurotransmitter dopamine becomes a novel target for CEST MRI. Furthermore, we proposed a novel methodology for accelerating CEST MRI and demonstrated its utility. Finally, we studied on the improvement of hyperpolarized 129Xe gas production method for use in HyperCEST MRI.

Research Products

• [Journal Article] Ethyl Pyruvate Improves Pulmonary Function in Mice with Bleomycin-induced Lung Injury as Monitored with Hyperpolarized ¹²⁹Xe MR Imaging (2018)
  • Author(s): Shota Hodono, Akihiro Shimokawa, Neil J. Stewart, Yukiko Yamauchi, Renya Nishimori, Mami Yamane, Hirohiko Imai, Hideaki Fujiwara, Atsuomi Kimura
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 17 Issue: 4 Pages: 331-337
  • DOI: 10.2463/mrms.mp.2017-0163
  • NAID: 130007496955
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access
• [Journal Article] Continuous flow production of concentrated hyperpolarized xenon gas from a dilute xenon gas mixture by buffer gas condensation. (2017)
  • Author(s): Imai H, Yoshimura H, Kimura A, Fujiwara H.
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 7352-7352
  • DOI: 10.1038/s41598-017-07695-7
  • Peer Reviewed / Open Access
• [Journal Article] Treatment response of ethyl pyruvate in a mouse model of chronic obstructive pulmonary disease studied by hyperpolarized 129Xe MRI. (2016)
  • Author(s): Kimura A, Yamauchi Y, Hodono S, Stewart NJ, Hosokawa O, Hagiwara Y, Imai H, Fujiwara H.
  • Journal Title: Magn Reson Med Volume: 印刷中 Issue: 2 Pages: 721-729
  • DOI: 10.1002/mrm.26458
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Hyperpolarized 129Xe MRI Using Isobutene as a New Quenching Gas (2016)
  • Author(s): Hodono S, Imai H, Yamauchi Y, Kawamura A, Matsumoto H, Okumura S, Fujiwara H, Kimura A.
  • Journal Title: NMR Biomed Volume: 29 Issue: 10 Pages: 1414-1419
  • DOI: 10.1002/nbm.3585
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Improving time resolution in the imaging of metabolic dynamics using compressed sensing from 2D heteronuclear multiple quantum coherence (2018)
  • Author(s): Utako Yamamoto, Hirohiko Imai, Kei Sano, Masayuki Ohzeki, Tetsuya Matsuda, Toshiyuki Tanaka
  • Organizer: Joint Annual Meeting ISMRM-ESMRMB
  • Int'l Joint Research
• [Presentation] 超偏極キセノンMRIによる肺繊維症の前臨床評価 (2018)
  • Author(s): 木村敦臣、下川晃弘、程野祥太、上田ひかり、Neil J. Stewart、山根麻実、西森廉弥、今井宏彦、藤原英明
  • Organizer: 第10回呼吸機能イメージング研究会学術集会
• [Presentation] 2次元1H-13C異種核多量子コヒーレンスMRSIにおける圧縮センシングを用いた時系列再構成 (2017)
  • Author(s): 山本詩子、今井宏彦、佐野圭、大関真之、松田哲也、田中利幸
  • Organizer: 第45回日本磁気共鳴医学会大会
• [Presentation] Gradient encoded CEST MRIにおける複数のZ-スペクトルの同時計測 (2017)
  • Author(s): 今井宏彦、三宅清隆、松田哲也
  • Organizer: 第45回日本磁気共鳴医学会大会
• [Presentation] スピン交換光ポンピングのイソブテンクエンチャー (2017)
  • Author(s): 今井宏彦
  • Organizer: 第45回日本磁気共鳴医学会大会 超偏極による多核MRSIの高感度計測スタディーグループ公開討論
• [Presentation] Time-series reconstruction using compressed sensing with ADMM in 2D magnetic resonance spectroscopic imaging (2017)
  • Author(s): Utako Yamamoto, Hirohiko Imai, Kei Sano, Masayuki Ohzeki, Tetsuya Matsuda, Toshiyuki Tanaka
  • Organizer: International Meeting on "High-Dimensional Data-Driven Science" (HD3-2017)
  • Int'l Joint Research
• [Presentation] Simultaneous acquisition of multiple Z-spectra using sinc-modulated RF pulse trains in gradient encoded CEST MRI (2017)
  • Author(s): Hirohiko Imai, Kiyotaka Miyake, Tetsuya Matsuda
  • Organizer: International Society for Magnetic Resonance in Medicine 25th Annual Meeting
  • Int'l Joint Research
• [Presentation] 超偏極キセノンガスを用いた二次元NMRによるカーボンナノチューブの細孔解析 (2016)
  • Author(s): 藤原英明、木村敦臣、今井宏彦、宮脇仁、尹聖昊、池田基、吉鉉植、出田圭子、齋藤公児、金橋康二
  • Organizer: 第55回NMR討論会
  • Place of Presentation: 広島国際会議場(広島県広島市)
  • Year and Date: 2016-11-16
• [Presentation] 循環型超偏極キセノンガスを利用したカーボンナノチューブのNMR分析 (2016)
  • Author(s): 齋藤公児、藤原英明、木村敦臣、程野祥太、今井宏彦、宮脇仁、尹聖昊、池田基、吉鉉植、出田圭子、金橋康二
  • Organizer: 日本分析化学会第65年会
  • Place of Presentation: 北海道大学工学部（北海道札幌市）
  • Year and Date: 2016-09-14
• [Presentation] Pulmonary functional imaging using quasi-completely hyperpolarized 129Xe MRI (2016)
  • Author(s): Atsuomi Kimura, Akihiro Shimokawa, Shota Hodono, Yu Ozaki, Naoto Miyazaki, Hirohiko Imai, Hideaki Fujiwara
  • Organizer: The 27th International Conference on Magnetic Resonance in Biological Systems
  • Place of Presentation: Kyoto (Japan)
  • Year and Date: 2016-08-21
  • Int'l Joint Research
• [Presentation] CEST/MTの基礎 (2015)
  • Author(s): 今井宏彦
  • Organizer: 第43回日本磁気共鳴医学会大会 教育講演
  • Place of Presentation: 東京ドームホテル（東京・文京）
  • Year and Date: 2015-09-12
• [Presentation] CEST MRIによるドパミン検出に関する基礎的検討 (2015)
  • Author(s): 今井宏彦、Jianchu Xu、松田哲也
  • Organizer: 第43回日本磁気共鳴医学会大会
  • Place of Presentation: 東京ドームホテル（東京・文京）
  • Year and Date: 2015-09-11
• [Presentation] 海外の最新事情－ISMRM2015 (2015)
  • Author(s): 服部峰之、今井宏彦
  • Organizer: 第43回日本磁気共鳴医学会大会 超偏極による多核MRSIの高感度計測スタディーグループ公開討論
  • Place of Presentation: 東京ドームホテル（東京・文京）
  • Year and Date: 2015-09-11
• [Presentation] 超偏極129Xe MRI肺機能診断法によるピルビン酸エチルの薬効評価 (2015)
  • Author(s): 下川晃弘、今井宏彦、山内紬起子、程野祥太、上田ひかり、野田雄哉、藤原英明、木村敦臣
  • Organizer: 第43回日本磁気共鳴医学会大会
  • Place of Presentation: 東京ドームホテル（東京・文京）
  • Year and Date: 2015-09-10
• [Presentation] 高沸点ガスをクエンチガスとする超偏極129Xe MRIの感度増強と肺繊維症診断への応用 (2015)
  • Author(s): 程野祥太、今井宏彦、山内紬起子、下川晃弘、野田雄哉、上田ひかり、藤原英明、木村敦臣
  • Organizer: 第43回日本磁気共鳴医学会大会
  • Place of Presentation: 東京ドームホテル（東京・文京）
  • Year and Date: 2015-09-10
• [Book] ``Brain imaging using hyperpolarized xenon MRI'' in ``Hyperpolarized and Inert Gas MRI. From Technology to Application in Research and Medicine'' (2016)
  • Author(s): Francis T Hane, Hirohiko Imai, Atsuomi Kimura, Hideaki Fujiwara, Madhwesha Rao, Jim Wild, Mitchell S Albert
  • Total Pages: 332
  • Publisher: Elsevier
• [Book] ``Development and application of mouse imaging using hyperpolarized xenon'' in ``Hyperpolarized and Inert Gas MRI. From Technology to Application in Research and Medicine'' (2016)
  • Author(s): Hirohiko Imai, Atsuomi Kimura, Hideaki Fujiwara
  • Total Pages: 332
  • Publisher: Elsevier
• [Patent(Industrial Property Rights)] 超偏極希ガス生成供給装置 (2017)
  • Inventor(s): 藤原英明、木村敦臣、今井宏彦
  • Industrial Property Rights Holder: 藤原英明、木村敦臣、今井宏彦
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2017-233022
  • Filing Date: 2017