Development of multiscale analysis of biosignal time series

• Project/Area Number: 15K01285
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Osaka University
• Principal Investigator: Kiyono Ken 大阪大学, 基礎工学研究科, 教授 (40434071)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 多重スケール解析 / 生体信号解析 / 心拍変動 / フラクタル解析 / スケーリング解析 / 長時間相互 / 長時間相関 / フラクタル / 非ガウス過程

Outline of Final Research Achievements

To analyze biosignal time series, fundamental theory and practical analysis methodology of the multiscale analysis were developed. As an important application of multiscale analysis methods, the long-range correlation analysis has been widely used. In this study, we developed a unified theory of detrending-operation-based random-walk analysis characterizing the long-range correlation observed in biosignal time series. As a practical detrending-operation, we established properties of Savitzky-Golay filter and developed a fast algorithm of the detrending-operation-based random-walk analysis using Savitzky-Golay filter. Moreover, as an application of the multiscale analysis to heart rate variability, we demonstrated that the multiscale analysis is applicable to cerebral infarction risk assessment and mortality risk assessment of cardiac patients.

Research Products

• [Int'l Joint Research] Politecnico di Torino(イタリア)
• [Int'l Joint Research] Ecole Normale Superieure de Lyon(フランス)
• [Int'l Joint Research] Ecole Normale Superieure de Lyon(フランス)
• [Int'l Joint Research] Politecnico di Torino(イタリア)
• [Journal Article] Association between Multiscale Entropy Characteristics of Heart Rate Variability and Ischemic Stroke Risk in Patients with Permanent Atrial Fibrillation (2017)
  • Author(s): Matsuoka Ryo、Yoshino Kohzoh、Watanabe Eiichi、Kiyono Ken
  • Journal Title: Entropy Volume: 19 Issue: 12 Pages: 672-672
  • DOI: 10.3390/e19120672
  • Peer Reviewed / Open Access
• [Journal Article] Fast algorithm for scaling analysis with higher-order detrending moving average method (2016)
  • Author(s): Yutaka Tsujimoto, Yuki Miki, Satoshi Shimatani, Ken Kiyono
  • Journal Title: Physical Review E Volume: 93 Issue: 5 Pages: 053304-053304
  • DOI: 10.1103/physreve.93.053304
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Detrending moving average algorithm: Frequency response and scaling performances (2016)
  • Author(s): Anna Carbone, Ken Kiyono
  • Journal Title: Physical Review E Volume: 93 Issue: 6 Pages: 063309-063309
  • DOI: 10.1103/physreve.93.063309
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Time and frequency domain characteristics of detrending-operation-based scaling analysis: Exact DFA and DMA frequency responses (2016)
  • Author(s): Ken Kiyono, Yutaka Tsujimoto
  • Journal Title: Physical Review E Volume: 94 Issue: 1 Pages: 012111-012111
  • DOI: 10.1103/physreve.94.012111
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Nonlinear filtering properties of detrended fluctuation analysis (2016)
  • Author(s): Ken Kiyono, Yutaka Tsujimoto
  • Journal Title: Physica A Volume: 462 Pages: 807-815
  • DOI: 10.1016/j.physa.2016.06.129
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Multiscale Analysis of Intensive Longitudinal Biomedical Signals and Its Clinical Applications (2016)
  • Author(s): T. Nakamura, K. Kiyono, H. Wendt, P. Abry, Y. Yamamoto
  • Journal Title: Proceedings of the IEEE Volume: 104 Issue: 2 Pages: 242-261
  • DOI: 10.1109/jproc.2015.2491979
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Establishing a direct connection between detrended fluctuation analysis and Fourier analysis (2015)
  • Author(s): Ken Kiyono
  • Journal Title: Physical Review E Volume: 92 Issue: 4 Pages: 042925-042925
  • DOI: 10.1103/physreve.92.042925
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Multiscale Entropy of the Heart Rate Variability for the Prediction of an Ischemic Stroke in Patients with Permanent Atrial Fibrillation (2015)
  • Author(s): Eiichi Watanabe, Ken Kiyono, Junichiro Hayano, Yoshiharu Yamamoto, Joji Inamasu, Mayumi Yamamoto, Tomohide Ichikawa, Yoshihiro Sobue, Masehide Harada, Yukio Ozaki
  • Journal Title: PLoS ONE Volume: 10 Issue: 9 Pages: e0137144-e0137144
  • DOI: 10.1371/journal.pone.0137144
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 機械学習による心不全予後予測能の向上 (2018)
  • Author(s): 越川真行, 本池雄二, 市川智英, 川合真由美, 原田将英, 渡邉英一, 尾崎行男, 清野健, 島谷哲史
  • Organizer: 日本ホルター・ ノンインベイシブ 心電学研究会
• [Presentation] 多重スケールSavitzky‐Golayフィルタを用いた生体信号の波形形状解析 (2018)
  • Author(s): 藤田壌, 清野健
  • Organizer: 計測自動制御学会関西支部・システム制御情報学会若手研究発表会
• [Presentation] Theory and applications of detrending-operation-based fractal-scaling analysis (2017)
  • Author(s): Ken Kiyono
  • Organizer: 2017 International Conference on Noise and Fluctuations (ICNF)
  • Int'l Joint Research / Invited
• [Presentation] Savitzky-Golay filter-based detrended fluctuation analysis: theory and its application to physiological time-series (2016)
  • Author(s): Yutaka Tsujimoto, Yasuyuki Suzuki, Masanori Shimono, Taishin Nomura, Ken Kiyono
  • Organizer: 8th International Workshop on Biosignal Interpretation
  • Place of Presentation: 大阪国際交流センター (大阪府・大阪市)
  • Year and Date: 2016-11-01
  • Int'l Joint Research
• [Presentation] Nonlinearity of heart rate variability induced by respiratory modulation (2016)
  • Author(s): Yuki Miki, Yasuyuki Suzuki, Masanori Shimono, Eiichi Watanabe, Junichiro Hayano, Yoshiharu Yamamoto, Taishin Nomura, Ken Kiyono
  • Organizer: 8th International Workshop on Biosignal Interpretation
  • Place of Presentation: 大阪国際交流センター (大阪府・大阪市)
  • Year and Date: 2016-11-01
  • Int'l Joint Research
• [Presentation] Scattering Transform of Heart Rate Variability for the Prediction of Ischemic Stroke in Patients with Atrial Fibrillation (2016)
  • Author(s): Roberto Leonarduzzi, Patrice Abry, Herwig Wendt, Ken Kiyono, Yoshiharu Yamamoto, Eiichi Watanabe, Junichiro Hayano
  • Organizer: 8th International Workshop on Biosignal Interpretation
  • Place of Presentation: 大阪国際交流センター (大阪府・大阪市)
  • Year and Date: 2016-11-01
  • Int'l Joint Research
• [Presentation] Long-range correlations in amplitude variability of HF and LF components of heart rate variability (2016)
  • Author(s): Yuki Miki, Yasuyuki Suzuki, Eiichi Watanabe, Junichiro Hayano, Yoshiharu Yamamoto, Taishin Nomura, Ken Kiyono
  • Organizer: 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: フロリダ (アメリカ)
  • Year and Date: 2016-08-16
  • Int'l Joint Research
• [Presentation] 心拍変動の高周波数及び低周波数成分の振幅変調にみられる長時間相関 (2015)
  • Author(s): 三木裕貴, 鈴木康之, 野村泰伸, 渡邉英一, 早野順一郎, 山本義春, 清野健
  • Organizer: 第31回心電情報処理ワークショップ
  • Place of Presentation: 名古屋クラウンホテル（愛知県名古屋市）
  • Year and Date: 2015-10-24
• [Presentation] 多重回帰分析による心臓植え込み型デバイスの需要推移予測 (2015)
  • Author(s): 島谷哲史, 渡邉英一, 鈴木康之, 野村泰伸, 清野健
  • Organizer: 第31回心電情報処理ワークショップ
  • Place of Presentation: 名古屋クラウンホテル（愛知県名古屋市）
  • Year and Date: 2015-10-24
• [Presentation] 慢性心房細動の心拍変動特性と予後との関係 (2015)
  • Author(s): 清野健，渡邉英一
  • Organizer: 第31回心電情報処理ワークショップ
  • Place of Presentation: 名古屋クラウンホテル（愛知県名古屋市）
  • Year and Date: 2015-10-24
• [Presentation] Multiscale non-Gaussian analysis based on Mellin transform: application to heart rate variability analysis (2015)
  • Author(s): Ken Kiyono
  • Organizer: Challenges in Data Science: a complex systems perspective
  • Place of Presentation: Castello del Valentino, Torino, Italy
  • Year and Date: 2015-10-14
  • Int'l Joint Research
• [Presentation] 心不全患者の予後予測因子としての心拍変動低周波成分の変調特性 (2015)
  • Author(s): 藤井翔太, 鈴木康之, 野村泰伸, 渡邉英一, 早野順一郎, 山本義春, 清野健
  • Organizer: 第54回日本生体医工学会大会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-05-07
• [Presentation] 心拍変動の時間相関に見られるスケーリングとクロスオーバー特性 (2015)
  • Author(s): 三木裕貴, 鈴木康之, 野村泰伸, 渡邉英一, 早野順一郎, 山本義春, 清野健
  • Organizer: 第54回日本生体医工学会大会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-05-07
• [Presentation] 睡眠時無呼吸症候群を合併した心疾患患者における終夜睡眠ポリグラフデータの特性と予後との関係 (2015)
  • Author(s): 松井翔二郎, 渡邉英一, 鈴木康之, 野村泰伸, 清野健
  • Organizer: 第54回日本生体医工学会大会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-05-07
• [Presentation] 心臓植込み型デバイスの国内手術件数分析に基づく将来需要予測モデルの構築 (2015)
  • Author(s): 島谷哲史, 渡邉英一, 鈴木康之, 野村泰伸, 清野健
  • Organizer: 第54回日本生体医工学会大会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-05-07
• [Presentation] 心拍変動に見られる分散不均一構造の解析 (2015)
  • Author(s): 森脇康貴, 鈴木康之, 野村泰伸, 渡邉英一, 早野順一郎, 山本義春, 清野健
  • Organizer: 第54回日本生体医工学会大会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-05-07
• [Presentation] 心拍変動の非線形特性 (2015)
  • Author(s): 清野健
  • Organizer: 第54回日本生体医工学会大会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-05-07