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Fully implantable brain functional measurement device

Research Project

Project/Area Number 15K01289
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionNara Institute of Science and Technology

Principal Investigator

Kiyotaka Sasagawa  奈良先端科学技術大学院大学, 物質創成科学研究科, 助教 (50392725)

Research Collaborator OHTA Jun  奈良先端科学技術大学院大学, 物質創成科学研究科, 教授 (80304161)
TOKUDA Takashi  奈良先端科学技術大学院大学, 物質創成科学研究科, 准教授 (50314539)
NODA Toshihiko  奈良先端科学技術大学院大学, 物質創成科学研究科, 助教 (20464159)
TAKEHARA Hiroaki  東京大学, 大学院工学系研究科マテリアル工学専攻, 助教 (60723088)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords生体埋植デバイス / イメージセンサ / 生体内通信 / 脳機能計測 / CMOSイメージセンサ / 埋植型デバイス
Outline of Final Research Achievements

In this study, a distributed multiple image sensor device was developed. The control signals for the image sensor are generated in the chip. And, a chip control signal is transmitted on the power line. Thus, the number of the input lines is reduced to two. We built a multiple sensor system that sensors were driven sequentially with only two lines.
As a way to reduce the number of lines, an implantable device based on intra-body communication technique. By contacting an image sensor with output electrodes on a mouse brain, weak electrical current signal was transmitted to another electrode on the body.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (33 results)

All 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 2 results) Presentation (30 results) (of which Int'l Joint Research: 7 results,  Invited: 1 results)

  • [Int'l Joint Research] メリーランド大学(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Implantable self-reset CMOS image sensor and its application to hemodynamic response detection in living mouse brain2016

    • Author(s)
      Takahiro Yamaguchi, Hiroaki Takehara, Yoshinori Sunaga, Makito Haruta, Mayumi Motoyama, Yasumi Ohta, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, and Jun Ohta
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 55 Issue: 4S Pages: 04EM02-04EM02

    • DOI

      10.7567/jjap.55.04em02

    • NAID

      210000146393

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Wireless image-data transmission from an implanted image sensor through a living mouse brain by intra body communication2016

    • Author(s)
      Hajime Hayami, Hiroaki Takehara, Kengo Nagata, Makito Haruta, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, and Jun Ohta
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 55 Issue: 4S Pages: 04EM03-04EM03

    • DOI

      10.7567/jjap.55.04em03

    • NAID

      210000146394

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 無機固体素子を用いたフィルム状脳内埋植用 フレキシブルデバイスの開発2017

    • Author(s)
      山口 貴大,須永 圭紀,春田 牧人,野田 俊彦,笹川 清隆,徳田 崇,太田 淳
    • Organizer
      H29年電気学会全国大会
    • Place of Presentation
      富山大学 五福キャンパス
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] 干渉フィルタを搭載した生体埋植型蛍光観察用デバイス用LED光源2017

    • Author(s)
      藤本 光輝、春田 牧人、野田 俊彦、笹川 清隆、徳田 崇、太田 淳
    • Organizer
      第64回応用物理学会春季学術講演会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2017-03-14
    • Related Report
      2016 Research-status Report
  • [Presentation] 非拘束リアルタイム脳機能計測に向けた埋植型多点撮像デバイス2017

    • Author(s)
      速水 一, 春田 牧人, 野田 俊彦, 笹川 清隆, 徳田 崇, 太田 淳
    • Organizer
      第64回応用物理学会春季学術講演会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2017-03-14
    • Related Report
      2016 Research-status Report
  • [Presentation] 生体イメージングに向けた埋植型高実効 SNR イメージセンサ2017

    • Author(s)
      笹川清隆,山口貴大,春田牧人,太田安美,野田俊彦,徳田崇,太田淳
    • Organizer
      "光応用電磁界計測( PEM )時限研究専門委員会"
    • Place of Presentation
      地方職員共済組合 有馬保養所 瑞宝園
    • Year and Date
      2017-02-16
    • Related Report
      2016 Research-status Report
  • [Presentation] Implantable Imaging Devices for Observation of Neural Activities2017

    • Author(s)
      Kiyotaka Sasagawa
    • Organizer
      The 2017 International Conference on Brain Informatics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Fluorescence Imaging Device with an Ultra-Thin Micro-LED2017

    • Author(s)
      Kiyotaka Sasagawa, Makito Haruta, Koki Fujimoto, Yasumi Ohta, Toshihiko Noda, Takashi Tokuda, Jun Ohta
    • Organizer
      The 13th IEEE BioCAS
    • Related Report
      2017 Annual Research Report
  • [Presentation] Implantable optoelectronic devices for measurement and control of neural functions2017

    • Author(s)
      Kiyotaka Sasagawa, Makito Haruta, Takahiro Yamaguchi, Koki Fujimoto, Yoshinori Sunaga, Yasumi Ohta, Toshihiko Noda, Takashi Tokuda, and Jun Ohta
    • Organizer
      The 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Related Report
      2017 Annual Research Report
  • [Presentation] Implantable multi-area imaging device with an optical data transmitter for brain function measurement2017

    • Author(s)
      Hajime Hayami, Makito Haruta, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, and Jun Ohta
    • Organizer
      The 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Related Report
      2017 Annual Research Report
  • [Presentation] An ultra-thin LED light source with excitation filters for an implantable imaging devices2017

    • Author(s)
      Kiyotaka Sasagawa, Koki Fujimoto, Takahiro Yamaguchi, Makito Haruta, Yasumi Ohta, Toshihiko Noda, Takashi Tokuda, Jun Ohta
    • Organizer
      9th International Conference on Molecular Electronics and bioelectronics
    • Related Report
      2017 Annual Research Report
  • [Presentation] A miniature imaging device using a self-reset image sensor for hemodynamic imaging2017

    • Author(s)
      Kiyotaka Sasagawa, Makito Haruta, Takahiro Yamaguchi, Yasumi Ohta, Toshihiko Noda, Takashi Tokuda, Jun Ohta,
    • Organizer
      2017 International Image Sensor Workshop (IISW)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 干渉フィルタ積層LED光源を搭載した生体埋植用CMOSイメージングデバイス2017

    • Author(s)
      藤本 光輝
    • Organizer
      VDECデザイナーズフォーラム2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] LDOレギュレータ/鋸波発振器搭載多機能PWM出力イメージセンサ2017

    • Author(s)
      速水 一
    • Organizer
      VDECデザイナーズフォーラム2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生体埋植用ニードル型ADC搭載CMOSイメージセンサのノイズ特性評価2017

    • Author(s)
      藤本 光輝, 笹川 清隆, 太田 安美, 春田 牧人, 野田 俊彦. 徳田 崇, 太田 淳
    • Organizer
      映像情報メディア学会年次大会2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高感度蛍光検出に向けた干渉フィルタ積層LED搭載生体埋植CMOSイメージングデバイス2017

    • Author(s)
      藤本 光輝, 笹川 清隆, 太田 安美, 野田 俊彦, 春田 牧人, 徳田 崇, 太田 淳
    • Organizer
      LSIとシステムのワークショップ2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 複数の脳内埋植型イメージセンサを搭載した多点撮像デバイスと近赤外線光を利用した画像伝送によるマウス用脳機能計測システム2017

    • Author(s)
      速水 一,春田 牧人,野田 俊彦,笹川 清隆,徳田 崇,太田 淳
    • Organizer
      LSIとシステムのワークショップ2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Multi-area Imaging Device by Using Implantable Image Sensors for Simple Brain Functional Imaging2016

    • Author(s)
      Hajime Hayami, Makito Haruta, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
    • Organizer
      2016 GLOBAL RESEARCH EFFORTS ON ENERGY AND NANOMATERIALS
    • Place of Presentation
      GIS TAIPEI TECH Convention Center,Taiwan
    • Year and Date
      2016-12-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] A packaging method for an implantable brain-machine interface device with a thin film substrate2016

    • Author(s)
      Takahiro Yamaguchi, Yoshinori Sunaga, Makito Haruta, Toshihiko Noda,Kiyotaka Sasagawa, Takashi Tokuda, and Jun Ohta
    • Organizer
      5th International Conference on BioSensors, BioElectronics, BioMedical Devices, BioMEMS/NEMS & Applications 2016 (Bio4Apps2016)
    • Place of Presentation
      Griffith University, QLD, Australia
    • Year and Date
      2016-12-14
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Hemodynamic Imaging Using an Implantable Self-Reset Image Sensor2016

    • Author(s)
      Kiyotaka Sasagawa, Takahiro Yamaguchi, Makito Haruta, Yasumi Ohta, Hiroaki Takehara, Toshihiko Noda, Takashi Tokuda, and Jun Ohta
    • Organizer
      The 12th IEEE BioCAS
    • Place of Presentation
      Hotel Pullman Shanghai Skyway
    • Year and Date
      2016-10-19
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] An Implantable Needle Shape Image Sensor with an On-Chip Thinned LED2016

    • Author(s)
      Kiyotaka Sasagawa, Takahiro Yamaguchi, Makito Haruta, Yoshinori Sunaga, Yasumi Ohta, Hironari Takehara, Hiroaki Takehara, Toshihiko Noda, Takashi Tokuda, Jun Ohta
    • Organizer
      2016 International Conference on Solid State Devides and Materials(SSDM2016)
    • Place of Presentation
      Tsukuba International Congress Center
    • Year and Date
      2016-09-28
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 複数の生体内埋め込み型センサを順次駆動する無線給電システム2016

    • Author(s)
      速水 一
    • Organizer
      VDECデザイナーズフォーラム2016
    • Place of Presentation
      東京大学武田先端知ビル
    • Year and Date
      2016-08-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 生体内通信により画像伝送が可能な埋植型多点撮像デバイス2016

    • Author(s)
      速水 一,竹原 宏明,野田 俊彦,笹川 清隆,徳田 崇,太田 淳
    • Organizer
      フィジカルセンサ/バイオ・マイクロシステム合同研究会
    • Place of Presentation
      機械振興会館
    • Year and Date
      2016-08-09
    • Related Report
      2016 Research-status Report
  • [Presentation] ブレイン・マシン・インターフェースに向けたフレキシブルデバイス2016

    • Author(s)
      山口 貴大,須永 圭紀,春田 牧人,竹原 宏明,野田 俊彦,笹川 清隆,徳田 崇,太田 淳
    • Organizer
      LSIとシステムのワークショップ2016
    • Place of Presentation
      東京大学 生産技術研究所
    • Year and Date
      2016-05-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 完全埋植型PWM出力イメージセンサによる生体内多点撮像システム2016

    • Author(s)
      速水 一,竹原 宏明,野田 俊彦,笹川 清隆,徳田 崇,太田 淳
    • Organizer
      LSIとシステムのワークショップ2016
    • Place of Presentation
      東京大学 生産技術研究所
    • Year and Date
      2016-05-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 埋込型CMOSイメージセンサによる マウス頭蓋骨を介した生体内光通信の原理実証2016

    • Author(s)
      永田 健悟,速水 一,竹原 宏明,野田 俊彦,笹川 清隆,徳田 崇,太田 淳
    • Organizer
      日本光学会情報フォトニクス研究グループ 関西学生研究論文講演会
    • Place of Presentation
      京都工芸繊維大学(京都府京都市)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Research-status Report
  • [Presentation] 協調的な脳活動計測に向けた多点撮像デバイス2015

    • Author(s)
      速水 一,永田健悟,竹原宏明,野田俊彦,笹川清隆,徳田 崇,太田 淳
    • Organizer
      電気学会 バイオ・マイクロシステム研究会
    • Place of Presentation
      物質・材料研究機構 並木地区(茨城県つくば市)
    • Year and Date
      2015-12-16
    • Related Report
      2015 Research-status Report
  • [Presentation] Improvement of power consumption and SNR of self-reset pixels for an implantable CMOS image sensor2015

    • Author(s)
      Takahiro Yamaguchi, Yoshinori Sunaga, Makito Haruta, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, and Jun Ohta
    • Organizer
      SSDM 2015
    • Place of Presentation
      Sapporo Convention Center, Japan
    • Year and Date
      2015-09-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Wireless Data Transmission in Brain Tissue with Intra-Body Communication by Micro-Sized Image Sensor2015

    • Author(s)
      Hajime Hayami, Kengo Nagata, Makito Haruta, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda and Jun Ohta
    • Organizer
      SSDM 2015
    • Place of Presentation
      Sapporo Convention Center, Japan
    • Year and Date
      2015-09-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 埋植用自己リセット型CMOSイメージセンサによる内因性シグナルの検出2015

    • Author(s)
      山口 貴大、須永 圭紀、春田 牧人、元山 真由美、太田 安美、 竹原 宏明、野田 俊彦、笹川 清隆、徳田 崇、太田 淳
    • Organizer
      応用物理学会秋季学術講演会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Research-status Report
  • [Presentation] 埋植型PWM出力イメージセンサを用いた生体内通信による画像伝送2015

    • Author(s)
      速水 一、永田 健吾、春田 牧人、竹原 宏明、 野田 俊彦、笹川 清隆、徳田 崇、太田 淳
    • Organizer
      応用物理学会秋季学術講演会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Research-status Report
  • [Presentation] LEDによる画像情報出力可能な 生体埋植型イメージングデバイスの開発2015

    • Author(s)
      永田 健悟、速水 一、竹原 宏明、笹川 清隆、野田 俊彦、徳田 崇、太田 淳
    • Organizer
      映像情報メディア学会 年次大会
    • Place of Presentation
      東京理科大学 葛飾キャンパス(東京都葛飾区)
    • Year and Date
      2015-08-26
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2022-01-24  

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