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Computer-controlled closed-loop drug infusion system for automated hemodynamic resuscitation in septic shock

Research Project

Project/Area Number 15K01307
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

UEMURA KAZUNORI  国立研究開発法人国立循環器病研究センター, 研究所, 室長 (10344350)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords敗血症性ショック / 治療システム / 循環モニター / 循環制御 / 超音波医学 / ベータ遮断薬 / 心房細動 / 敗血症 / ショック / ランジオロル / 初期蘇生 / 生体制御 / 生体治療 / 循環管理 / 迷走神経
Outline of Final Research Achievements

Septic shock is caused by serious infection such as pneumonia or peritonitis, and associated with a high risk of in-hospital mortality (20%). Specific hemodynamic management is mandatory for hemodynamic resuscitation from septic shock. However, since responses to the hemodynamic treatments varies between patients, and within patients over time, strict monitoring of the patient hemodynamic condition, and frequent adjustments of the treatment are required. To overcome this problems, we have developed a computer-controlled automated hemodynamic management system of septic shock, and validated its good performance in canine model of septic shock. Furthermore, we have integrated this system with beta-blockade treatment, whose efficacy in treatment of septic shock is recently demonstrated. Our system thus developed may be an attractive clinical tool in rescuing patients with septic shock.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (26 results)

All 2017 2016 2015 Other

All Journal Article (8 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 8 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (14 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Computer-controlled closed-loop drug infusion system for automated hemodynamic resuscitation in endotoxin-induced shock2017

    • Author(s)
      Uemura Kazunori、Kawada Toru、Zheng Can、Li Meihua、Sugimachi Masaru
    • Journal Title

      BMC Anesthesiology

      Volume: 17 Issue: 1 Pages: 1-13

    • DOI

      10.1186/s12871-017-0437-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Acute ivabradine treatment reduces heart rate without increasing atrial fibrillation inducibility irrespective of underlying vagal activity in dogs2017

    • Author(s)
      Uemura K, Inagaki M, Zheng C, Kawada T, Li M, Fukumitsu M, Sugimachi M
    • Journal Title

      Heart Vessels.

      Volume: 32 Issue: 4 Pages: 484-494

    • DOI

      10.1007/s00380-016-0922-y

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Wave reflection correlates with pulmonary vascular wall thickening in rats with pulmonary arterial hypertension.2017

    • Author(s)
      Fukumitsu M, Kawada T, Shimizu S, Turner MJ, Uemura K, Sugimachi M.
    • Journal Title

      Int J Cardiol.

      Volume: 249 Pages: 396-401

    • DOI

      10.1016/j.ijcard.2017.09.024

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frequent drinking of small volumes improves cardiac function and survival in rats with chronic heart failure.2017

    • Author(s)
      Zheng C, Li M, Kawada T, Inagaki M, Uemura K, Sugimachi M
    • Journal Title

      Physiol Rep.

      Volume: 5 Issue: 21

    • DOI

      10.14814/phy2.13497

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of Proximal Pulmonary Artery Occlusion on Pulsatile Right Ventricular Afterload in Rats2016

    • Author(s)
      Fukumitsu M, Kawada T, Shimizu S, Turner MJ, Uemura K, Sugimachi M.
    • Journal Title

      Circulation Journal

      Volume: 80 Issue: 9 Pages: 2010-2018

    • DOI

      10.1253/circj.CJ-16-0349

    • NAID

      130005406868

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of a servo pump system for in vivo loading of pathological pulmonary artery impedance on the right ventricle of normal rats.2016

    • Author(s)
      Fukumitsu M, Kawada T, Shimizu S, Turner MJ, Uemura K, Sugimachi M
    • Journal Title

      American Journal of Physiology: Heart and Circulatory Physiology

      Volume: 310 Issue: 8 Pages: 973-983

    • DOI

      10.1152/ajpheart.00813.2015

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Less invasive and inotrope-reduction approach to automated closed-loop control of hemodynamics in decompensated heart failure.2015

    • Author(s)
      Uemura K, Kawada T, Zheng C, Sugimachi M.
    • Journal Title

      IEEE Trans Biomed Eng

      Volume: Nov 11. [Epub ahead of print] Issue: 8 Pages: 1-10

    • DOI

      10.1109/tbme.2015.2499782

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A novel technique to predict pulmonary capillary wedge pressure utilizing central venous pressure and tissue Doppler tricuspid/mitral annular velocities.2015

    • Author(s)
      Uemura K, Inagaki M, Zheng C, Li M, Kawada T, Sugimachi M.
    • Journal Title

      Heart Vessels.

      Volume: 30 Issue: 4 Pages: 516-526

    • DOI

      10.1007/s00380-014-0525-4

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Computer-controlled de-coupling between heart rate and cardiac contractility improves cardiac energetics while restoring normal hemodynamics in acute heart failure Theoretical and experimental analyses -2017

    • Author(s)
      Uemura K, Sugimachi M
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Acute ivabradine treatment reduces heart rate without increasing atrial fibrillation inducibility irrespective of underlying vagal activity in dogs2017

    • Author(s)
      Uemura K, Inagaki M, Zheng C, Kawada T, Li M, Fukumitsu M, Sugimachi M
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] Development of closed-loop drug infusion system for automated hemodynamic resuscitation in septic shock2017

    • Author(s)
      Uemura K, Kawada T, Zheng C, Li M, Sugimachi M.
    • Organizer
      European Society of Cardilogy Congress 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] COMPUTERCONTROLLED CLOSEDLOOP DRUG INFUSION SYSTEM FOR AUTOMATED HEMODYNAMIC RESUSCITATION IN SEPTIC SHOCK2017

    • Author(s)
      Uemura K, Kawada T, Zheng C, Li M, Sugimachi M.
    • Organizer
      30th European Society of Intensive Care Medicine (ESICM) Annual Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of computer-controlled closed-loop drug infusion system for automated hemodynamic resuscitation in endotoxin-induced septic shock2017

    • Author(s)
      Uemura K, Kawada T, Zheng C, Li M, Sugimachi M.
    • Organizer
      第82回日本循環器学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Short-acting β-blocker safely reduces heart rate without compromising initial hemodynamic resuscitation in endotoxin-induced septic shock2017

    • Author(s)
      Uemura K, Kawada T, Zheng C, Li M, Sugimachi M.
    • Organizer
      第82回日本循環器学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 敗血症性ショックにおける循環管理を支援する、コンピュータ制御自動循環蘇生システムの開発2017

    • Author(s)
      上村和紀、川田徹、鄭燦、李梅花、杉町勝
    • Organizer
      第56 回日本生体医工学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Ivabradine reduces heart rate safely without increasing atrial fibrillation inducibility, irrespective of underlying vagal activity, in dogs2016

    • Author(s)
      Uemura K, Inagaki M, Zheng C, Kawada T, Li M, Fukumitsu M, Sugimachi M
    • Organizer
      ESC congress 2016
    • Place of Presentation
      ローマ、イタリア
    • Year and Date
      2016-08-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 徐脈薬イバブラジンの心房細動誘発リスクの検討 -迷走神経活動との相互作用の解析-2016

    • Author(s)
      上村和紀、稲垣正司、鄭燦、川田徹、李梅花、福満雅史、杉町勝
    • Organizer
      第37回日本循環制御医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-08
    • Related Report
      2016 Research-status Report
  • [Presentation] 心不全循環管理を支援する血行動態自動制御システムの、臨床応用を目指した低侵襲化2016

    • Author(s)
      上村和紀、川田徹、鄭燦、杉町勝
    • Organizer
      第55回日本生体医工学会大会
    • Place of Presentation
      富山
    • Year and Date
      2016-04-26
    • Related Report
      2016 Research-status Report
  • [Presentation] Less invasive and guideline-oriented approach to automated closed-loop control of hemodynamics in decompensated heart failure2016

    • Author(s)
      Uemura K, et al.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Computer-controlled infusion system of cardiovascular drugs to automatically optimize hemodynamics in decompensated heart failure2015

    • Author(s)
      Uemura K, et al.
    • Organizer
      ESC Congress 2015
    • Place of Presentation
      London, UK
    • Year and Date
      2015-08-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 循環管理を支援する、血行動態自動制御システムの低侵襲化 -臨床応用を見据えて-2015

    • Author(s)
      上村和紀ら
    • Organizer
      第36回日本循環制御医学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-06-05
    • Related Report
      2015 Research-status Report
  • [Presentation] Development of a novel technique to predict left heart filling pressure utilizing tissue Doppler tricuspid/mitral annular velocity ratio2015

    • Author(s)
      Uemura K, et al.
    • Organizer
      第54回日本生体医工学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-05-07
    • Related Report
      2015 Research-status Report
    • Invited
  • [Remarks] 重症心不全患者さんの診療を支援する、コンピュータ制御循環管理システムの開発

    • URL

      http://www.ncvc.go.jp/about/excellence/10.html

    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] 血管弾性指標値測定装置、血圧測定装置及び血管弾性指標値測定方法2016

    • Inventor(s)
      上村和紀ら
    • Industrial Property Rights Holder
      国立循環器病研究センター
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-009128
    • Filing Date
      2016-01-20
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 血管弾性指標値測定装置、血圧測定装置及び血管弾性指標値測定方法2016

    • Inventor(s)
      上村和紀ら
    • Industrial Property Rights Holder
      国立循環器病研究センター
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-009129
    • Filing Date
      2016-01-20
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 血圧計測装置及び血圧計測方法2015

    • Inventor(s)
      上村和紀ら
    • Industrial Property Rights Holder
      国立循環器病研究センター
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-105496
    • Filing Date
      2015-05-25
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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