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Superfine Magnetic Resonance Imaging of the Cerebrovasculature by polymeric contrast agent

Research Project

Project/Area Number 15K01308
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

Mahara Atsushi  国立研究開発法人国立循環器病研究センター, 研究所, 室長 (80416221)

Co-Investigator(Kenkyū-buntansha) 山岡 哲二  国立研究開発法人国立循環器病研究センター, 研究所, 部長 (50243126)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords高分子MRI造影剤 / 脳血管イメージング / MRA / MRI / 高分子造影剤 / ガドリニウム / 微細血管 / 造影
Outline of Final Research Achievements

In this study, we developed a polymeric Gd-conjugated contrast agent for high-resolution imaging of cerebrovasculature. The branched polyethylene glycols having approximately 15 kDa of molecular weight were conjugated with Gd-chelate and fluorescein. We showed that microvasculature network could be visualized with the resolution of 100 μm by using the contrast agents. Experimental results indicated that relaxivity increasing was induced by the branch structure, and the agents were excreted in urine after 24 hours for the administration. Inflammatory markers in the blood were not induced by the injection. Moreover, we succeeded in proving the possibility that cerebral ischemia region and collateral flow were clearly visualized with the polymeric contrast agents in middle cerebral artery occlusion model rats.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2018 2017 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (9 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Superfine Magnetic Resonance Imaging of the Cerebrovasculature Using Self-Assembled Branched Polyethylene Glycol-Gd Contrast Agent2018

    • Author(s)
      Atsushi Mahara,* Jun-ichiro Enmi, Yu-I Hsu, Naoki Kobayashi, Yoshiaki Hirano, Hidehiro Iida, and Tetsuji Yamaoka*
    • Journal Title

      Macromolecular Bioscience

      Volume: 18(5) Issue: 5

    • DOI

      10.1002/mabi.201700391

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] 脳微細血管造影を目指した自己凝集型高分子MRI造影剤2017

    • Author(s)
      馬原淳
    • Organizer
      第66回高分子討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] MR imaging of the cerebrovasculature by self-assembled 8-arm polyethylene glycol-Gd contrast agent2017

    • Author(s)
      Atsushi Mahara
    • Organizer
      第45回日本磁気共鳴医学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Super-fine magnetic resonance imaging probe for the cerebrovasculature using self-assembled polymers2017

    • Author(s)
      Atsushi Mahara
    • Organizer
      52nd ACS Fall meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gd標識分岐型ポリエチレングリコールによる脳微細血管イメージングの造影メカニズム2017

    • Author(s)
      31.馬原 淳
    • Organizer
      第12回 分子イメージング学会総会・学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Brain microvessel imaging with polymeric MRI contrast agent2016

    • Author(s)
      馬原 淳
    • Organizer
      issue Engineering and Regenerative Medicine annual meeting 2016
    • Place of Presentation
      Manchester Grand Hyatt San Diego, San Digeno, CA
    • Year and Date
      2016-12-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Polymeric MRI contrast agent for visualization of brain microvessels2016

    • Author(s)
      馬原 淳
    • Organizer
      第65回高分子討論会
    • Place of Presentation
      神奈川大学 横浜キャンパス
    • Year and Date
      2016-09-14
    • Related Report
      2016 Research-status Report
  • [Presentation] 脳微細血管を可視化する高分子MRI造影剤2016

    • Author(s)
      馬原 淳
    • Organizer
      第45回医用高分子シンポジウム
    • Place of Presentation
      産業技術総合研究所臨海副都心センター別館11階会議室
    • Year and Date
      2016-07-25
    • Related Report
      2016 Research-status Report
  • [Presentation] Brain microvessel imaging by polymeric MRI contrast agent2015

    • Author(s)
      馬原 淳
    • Organizer
      第64回高分子学会年次大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2015-05-27
    • Related Report
      2015 Research-status Report
  • [Presentation] Brain microvessel imaging by polymeric MRI contrast agent2015

    • Author(s)
      馬原 淳
    • Organizer
      第10回日本分子イメージング学会学術集会
    • Place of Presentation
      タワーホール船堀
    • Year and Date
      2015-05-20
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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