| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Protein adsorption is initially induced at the surface of the material and is an important biological response that determines subsequent biological responses. In this research, we aimed to understand protein adsorption from the viewpoint of intermolecular interaction working on the material surface. Specifically, we analyzed the intermolecular interactions that a protein takes to construct an adsorption layer using a series of well-defined polymer brush surfaces composed of various chemical structures. It was found that the intermolecular interaction works not to act as a driving force to attract the protein to the materials surface, but to prevent the detachment of the protein contacting the materials surface. It was also found that as the intermolecular interaction is larger, the higher order structure of the adsorbed protein changes, leading to the multilayer adsorption.
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