Design and biomaterial application of nucleic acid-clipping nanogel
| Project/Area Number |
15K01312
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ナノゲル / 多糖 / オリゴ核酸 / 架橋化核酸 / 二重鎖形成 / 自己組織化 / 核酸 / 温度応答性 / 刺激応答性 / 疎水化多糖 |
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| Outline of Final Research Achievements |
Polymer gel nanoparticles having physically cross-linking points by self-associating molecules have attracted attention as bio/medical material in recent years. In this study, we constructed novel self-assemble gel particles (nucleic acid-clipping nanogel) by the duplex formation of complementary oligonucleic acids as an associative factor controlling the gel structure. Oligonucleic acid substituted pullulan was synthesized by click chemistry from azido group modified pullulan that is a water-soluble polysaccharide and alkyne modified oligonucleic acid. The oligonucleic acid substituted pullulan formed nanosize gel particles (about 100 nm) by duplex formation of oligonucleic acid in buffer.
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Report
(4 results)
Research Products
(11 results)
