Development of molecular targeting systm for various chonic diseases by GlcNAc-bearing polymer
| Project/Area Number |
15K01313
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Kyushu University |
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Principal Investigator |
ISE Hirohiko 九州大学, 先導物質化学研究所, 准教授 (10324253)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ビメンチン / デスミン / GFAP / ペリフェリン / 慢性炎症性疾患 / GlcNAc / 糖鎖高分子 / レクチン / N-アセチルグルコサミン / 炎症 |
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| Outline of Final Research Achievements |
In this study, we developed molecular targeting system for various chronic diseases. At these lesion sites, many activated myofibroblasts and stellate cells are proliferated. These cells highly express type 3 intermediate filaments (vimentin, desmin, glial fibrillary acidic protein(GFAP), and peripherin). We found that these proteins are expressed on cell surface and have N-acetylglucosamine (GlcNAc)-binding activities. Moreover, new GlcNAc-bearing polymer, AC-GlcNAc, that can rigidly bind to these proteins was developed. These findings are very useful for developing molecular targeting system for various chronic diseases.
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Report
(4 results)
Research Products
(28 results)
