| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
In this study, we developed molecular targeting system for various chronic diseases. At these lesion sites, many activated myofibroblasts and stellate cells are proliferated. These cells highly express type 3 intermediate filaments (vimentin, desmin, glial fibrillary acidic protein(GFAP), and peripherin). We found that these proteins are expressed on cell surface and have N-acetylglucosamine (GlcNAc)-binding activities. Moreover, new GlcNAc-bearing polymer, AC-GlcNAc, that can rigidly bind to these proteins was developed. These findings are very useful for developing molecular targeting system for various chronic diseases.
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