| Project/Area Number |
15K01316
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
高橋 康仁 東京医科大学, 医学部, 助教 (60567668)
宍戸 孝明 東京医科大学, 医学部, 准教授 (70266500)
立岩 俊之 東京医科大学, 医学部, 講師 (00424630)
山本 謙吾 東京医科大学, 医学部, 教授 (10246316)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 人工股関節 / 高度架橋ポリエチレン / ビタミンＥ / 微細構造 / 力学特性 / 超高分子量ポリエチレン / 人工関節 / ポリエチレン |
|---|
| Outline of Final Research Achievements |
Vitamin E (Vit-E) is a powerful antioxidant for highly cross-linked polyethylene (XLPE) used in total hip arthroplasty. However, the effects of Vit-E incorporation on mechanical behavior of XLPE remain to be fully elucidated. In this study, we attempted to explore mechanical role of Vit-E in XLPE acetabular liners on the molecular scale. The comparisons between Vit-E free/blended liners indicated that the presence of Vit-E might promote polyethylene chain mobility in the cross-linked structure, resulting in the significant surface anisotropy. Such aspects of antioxidant Vit-E blending would imply the possibility of the increased micromechanical wear through the strain-softening phenomena. Nevertheless, wear resistance could be further improved by the more rigid control of molecular movements.
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