Identification of optimized specifications of artificial extracellular environment for stem cell culture and spheroid formation

• Project/Area Number: 15K01318
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Tokyo University of Pharmacy and Life Science
• Principal Investigator: Kentaro Hozumi 東京薬科大学, 薬学部, 講師 (10453804)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ペプチド / キトサン / インテグリン / シンデカン / 受容体間クロストーク / 細胞接着 / 細胞培養基質 / 細胞外マトリックス / ラミニン / フィブロネクチン / クロストーク / 幹細胞 / スフェロイド

Outline of Final Research Achievements

Extracellular matrix proteins are important factor to maintain the stem cell culture in vitro. Multi-extracellular matrix derived active peptides immobilized chitosan matrices were developed to construct the cell culture scaffold. We immobilized various integrin binding peptides on chitosan matrix to investigate the integrin-integrin cross-talks between different integrin subtypes using multi-peptide-chitosan matrices. The biological activities of multi integrin binding peptide-chitosan matrices could enhance by the optimized combinations and mixture ratios of different active peptides. Further, fibronectin mimicked multi integrin binding peptide-chitosan matrices could develop using the fibronectin derived peptides. These findings are important to control the biological activities of cell culture scaffold to culture the stem cell.

Research Products

• [Journal Article] Cell adhesion activity of peptides conjugated to polysaccharides (2018)
  • Author(s): Hozumi Kentaro、Nomizu Motoyoshi
  • Journal Title: Current Protocols in Cell Biology Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Synthesis of a Chloroalkene Dipeptide Isostere-Containing Peptidomimetic and Its Biological Application (2018)
  • Author(s): Takuya Kobayakawa, Yudai Matsuzaki, Kentaro Hozumi, Wataru Nomura, Motoyoshi Nomizu, Hirokazu Tamamura
  • Journal Title: ACS Med. Chem. Lett. Volume: 9 Issue: 1 Pages: 6-10
  • DOI: 10.1021/acsmedchemlett.7b00234
  • Peer Reviewed / Open Access
• [Journal Article] Identification of laminin α5 short arm peptides active for endothelial cell attachment and tube formation. (2017)
  • Author(s): Kikkawa, Y., Sugawara, Y., Harashima, N., Fujii, S., Ikari, K., Kumai, J., Katagiri, F., Hozumi, K., and Nomizu, M.
  • Journal Title: Journal of Peptide Science Volume: 印刷中 Issue: 7-8 Pages: 666-673
  • DOI: 10.1002/psc.2987
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Biological activity of peptide-conjugated polyion complex matrices consisting of alginate and chitosan. (2017)
  • Author(s): Fujimori, C‡., Kumai, J‡., Nakamura, K., Gu, Y., Hozumi, K., Katagiri, F., Kikkawa, Y., and Nomizu, M
  • Journal Title: Biopolymers Volume: 108 Issue: 1 Pages: 356-366
  • DOI: 10.1002/bip.22983
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] An anti-human lutheran glycoprotein phage antibody inhibits cell migration on laminin-511: epitope mapping of the antibody. (2017)
  • Author(s): Enomoto-Okawa Y, Maeda Y, Harashima N, Sugawara Y, Katagiri F, Hozumi K, Hui KM, Nomizu M, Ito Y, Kikkawa Y
  • Journal Title: PLoS One Volume: 12 Issue: 1 Pages: e0167860-e0167860
  • DOI: 10.1371/journal.pone.0167860
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Mixed Fibronectin-Derived Peptides Conjugated to a Chitosan Matrix Effectively Promotes Biological Activities through Integrins, α4β1, α5β1, αvβ3, and Syndecan. (2016)
  • Author(s): Kentaro Hozumi, Kyotaro Nakamura, Haruna Hori, Mari Miyagi, Rika Nagao, Keiko Takasaki, Fumihiko Katagiri, Yamato Kikkawa, and Motoyoshi Nomizu
  • Journal Title: Biores Open Access Volume: 5 Issue: 1 Pages: 356-366
  • DOI: 10.1089/biores.2016.0037
  • Peer Reviewed / Open Access
• [Journal Article] Effect of spacer length and type on the biological activity of peptide-polysaccharide matrices. (2016)
  • Author(s): Kumai, J, Hozumi, K, Yamada, Y, Katagiri, F, Kikkawa, Y, Nomizu, M
  • Journal Title: Biopolymers Volume: 印刷中 Issue: 4 Pages: 512-520
  • DOI: 10.1002/bip.22785
  • Peer Reviewed / Open Access
• [Journal Article] Down-regulation of cell adhesion via rho-associated protein kinase (ROCK) pathway promotes tumor cell migration on laminin-511 (2016)
  • Author(s): Kikkawa Y, Harashima N, Ikari K, Fujii S, Katagiri F, Hozumi K, Nomizu M
  • Journal Title: Exp Cell Res Volume: 344 Issue: 1 Pages: 76-85
  • DOI: 10.1016/j.yexcr.2016.04.002
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] α-ジストログリカン結合ペプチドA2G80の構造活性相関研究 (2018)
  • Author(s): 片桐 文彦、深澤 由佳、熊井 準、保住建太郎、吉川 大和、野水 基義
  • Organizer: 日本薬学会第138年会
• [Presentation] ラミニンペプチドを用いた新規ペプチド-アガロースマトリックスの開発 (2018)
  • Author(s): 熊井 準、片桐 文彦、保住建太郎、吉川 大和、野水 基義
  • Organizer: 日本薬学会第138年会
• [Presentation] アミロイド様線維形成ラセミ混合ペプチドの生物活性 (2017)
  • Author(s): 片桐 文彦，森 香子，保住 建太郎，吉川 大和，野水 基義
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台
  • Year and Date: 2017-03-24
• [Presentation] ポリイオンコンプレックス法による新規バイオマテリアルの開発 (2017)
  • Author(s): 中村 亨太郎, 熊井 準, 藤森 能, 片桐 文彦, 保住 建太郎, 吉川 大和, 野水 基義
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台
  • Year and Date: 2017-03-24
• [Presentation] レプリカ交換法を用いた細胞接着活性を持つ直鎖および環状化ペプチドの構造解析 (2017)
  • Author(s): 山田 寛尚、宮川 毅、森河 良太、片桐 文彦、保住 建太郎、吉川 大和、野水 基義、高須 昌子
  • Organizer: 日本物理学会第72回年次大会
  • Place of Presentation: 大阪
  • Year and Date: 2017-03-17
• [Presentation] Fibronectin derived peptides conjugated chitosan matrix promotes neurite outgrowth and cell adhesion via integrin and syndecan (2017)
  • Author(s): K. Hozumi, K. Nakamura, H. Hori, M. Miyagi, R. Nagao, F. Katagiri, Y. Kikkawa, M. Nomizu
  • Organizer: The 2017 Japan-NIH Joint Symposium on Advances in Biomedical Research and Disease
  • Place of Presentation: 仙台
  • Year and Date: 2017-02-15
  • Int'l Joint Research
• [Presentation] Prepration of novel biomaterial using polyion complex matrix (2017)
  • Author(s): J. Kumai, K. Nakamura, C. Fujimori, F. Katagiri, K. Hozumi, Y. Kikkawa, M. Nomizu
  • Organizer: The 2017 Japan-NIH Joint Symposium on Advances in Biomedical Research and Disease
  • Place of Presentation: 仙台
  • Year and Date: 2017-02-15
  • Int'l Joint Research
• [Presentation] Development of laminin active-peptide conjugated chitosan hydrogel crosslinked by dicarboxylic acids on Phosphorylation of Focal Adhesion Kinase (2017)
  • Author(s): K. Hozumi, H. Yamada, F. Katagiri, Y. Kikkawa, M. Nomizu
  • Organizer: ACS 254th National Meeting
  • Int'l Joint Research
• [Presentation] ラミニン由来活性ペプチド-キトサンゲルを用いた唾液腺細胞分化促進活性の評価 (2017)
  • Author(s): 保住建太郎、山田 隼人、片桐 文彦、吉川 大和、野水 基義
  • Organizer: 第66回高分子討論会
• [Presentation] Development of laminin active peptide-polysaccharide matrices as cell adhesive biomaterials (2017)
  • Author(s): K. Hozumi, J. Kumai, F. Katagiri, Y. Kikkawa, M. Nomizu
  • Organizer: The 16th International Symposium on Advanced Technology
  • Int'l Joint Research
• [Presentation] Integrin alphavbeta3 and alpha6beta1 cross-talk of dermal fibroblasts on integurin specific peptide chitosan matrix (2017)
  • Author(s): K. Hozumi, S. Enomoto, Y. Teranishi, F. Katagiri, Y. Kikkawa, M. Nomiz
  • Organizer: ASCB/EMBO 2017 meeting
  • Int'l Joint Research
• [Presentation] アミロイド様線維形成ペプチドのシグナル伝達に与える影響 (2017)
  • Author(s): 片桐 文彦、森 香子、保住建太郎、吉川 大和、野水 基義
  • Organizer: 日本ケミカルバイオロジー学会 第12回年会
• [Presentation] Identification of integrin cross-talk on dermal fibroblasts using peptide polysaccharide matrix (2017)
  • Author(s): 保住建太郎、榎本沙也香、寺西 唯、片桐 文彦、吉川 大和、野水 基義
  • Organizer: 第49回日本結合組織学会
• [Presentation] ラミニン-511による細胞運動におけるLu/B-CAMとスペクトリン相互作用の役割 (2017)
  • Author(s): 菅原由美香、原島 望、碇 和樹、片桐 文彦、保住建太郎、野水 基義、吉川 大和
  • Organizer: 第49回日本結合組織学会
• [Presentation] Effect of racemic amyloidogenic peptides on Phosphorylation of Focal Adhesion Kinase (2017)
  • Author(s): Katagiri F, Mori K, Hozumi K, Kikkawa Y, and Nomizu M.
  • Organizer: 25th American Peptide Symposium
  • Int'l Joint Research
• [Presentation] The role of Lu/B-CAM spectrin binding motif in cell migration on LM-511 (2017)
  • Author(s): Y. Kikkawa, Y. Sugawara, N. Harashima, K. Ikari, F. Katagiri, K. Hozumi, M. Nomizu
  • Organizer: Basement membrane workshop
  • Int'l Joint Research
• [Presentation] αDG結合ペプチドA2G80の分子動力学シミュレーションによる構造解析 (2017)
  • Author(s): 山田 寛尚，深澤 由佳，宮川 毅, 森河 良太, 片桐 文彦, 保住建太郎，吉川 大和，野水 基義，高須 昌子
  • Organizer: 日本物理学会2017年秋季大会
• [Presentation] Identification of laminin α5 short arm peptides active for endothelial cell attachment and tube formation (2017)
  • Author(s): X. Yang, Y. Sugawara, N. Harashima, S. Fujii, K. Ikari, F. Katagiri, K. Hozumi, Y. Kikkawa, M. Nomizu
  • Organizer: 第54回日本ペプチド討論会
• [Presentation] Structure-activity relationship study For α-dystroglycan binding peptide A2G80 derived from mouse laminin α2 chain sequence (2017)
  • Author(s): Katagiri F, Fukasawa Y, Kumai J, Hozumi K, Kikkawa Y, and Nomizu M.
  • Organizer: 第54回日本ペプチド討論会
• [Presentation] Dentification of α-dystroglycan binding sequence in the laminin α2 chain LG4-5 module using peptide-chitosan matirx ELIZA method (2017)
  • Author(s): G. Zhang, J. Kumai, K. Ikari, Y. Xiao, Y. Sugawara, F. Katagiri, K. Hozumi, Y. Kikkawa, M. Nomizu
  • Organizer: 第54回日本ペプチド討論会
• [Presentation] Internalization of CD239, a laminin receptor, in human breast cancer: a novel antigen for antibody-drug conjugates (2017)
  • Author(s): Y. Kikkawa, Y. Enomoto-Okawa, A. Fujiyama, T. Fukuhara, N. Harashima, Y. Sugawara, K. Ikari, Y. Negishi, F. Ktagiri, K. Hozumi, M. Nomizu, Y. Ito
  • Organizer: ASCB/EMBO 2017 meeting
• [Presentation] Structure-activity relationship study for α-dystroglycan binding peptide A2G80 derived from mouse laminin α2 chain sequence (2017)
  • Author(s): F. Katagiri, Y. Fukasawa, J. Kumai, K. Hozumi, Y. Kikkawa, M. Nomizu
  • Organizer: ASCB/EMBO 2017 meeting
  • Int'l Joint Research
• [Presentation] Mixed fibronectin derived peptides conjugated chitosan matrix effectively promotes biological activities via integrin a4b1, a5b1, avb3, and syndecan (2016)
  • Author(s): K. Hozumi, K. Nakamura, H. Hori, M. Miyagi, R. Nagao, F. Katagiri, Y. Kikkawa, M. Nomizu
  • Organizer: 2016 Annual Meeting the American Society for Cell Biology
  • Place of Presentation: San Francisco (USA)
  • Year and Date: 2016-12-03
  • Int'l Joint Research
• [Presentation] The involvement of Lu/B-CAM spectrin binding motif in cell migration on LM-511 (2016)
  • Author(s): Y. Sugawara, N. Harashima, S. Fujii, K. Ikari, F. Katagiri, K. Hozumi, M. Nomizu, Y. Kikkawa
  • Organizer: 2016 Annual Meeting the American Society for Cell Biology
  • Place of Presentation: San Francisco (USA)
  • Year and Date: 2016-12-03
  • Int'l Joint Research
• [Presentation] Identification of laminin α5 short arm peptides active for endothelial cell attachment and tube formation (2016)
  • Author(s): N. Harashima, Y. Sugawara, K. Ikari, F. Katagiri, K. Hozumi, M. Nomizu, Y. Kikkawa
  • Organizer: 2016 Annual Meeting the American Society for Cell Biology
  • Place of Presentation: San Francisco (USA)
  • Year and Date: 2016-12-03
  • Int'l Joint Research
• [Presentation] The phosphorylation of focal adhesion kinase in human dermal fibroblasts on chiral/racemic amyloid-like fibrils (2016)
  • Author(s): F. Katagiri, K. Mori, K. Hozumi, Y. Kikkawa, M. Nomizu
  • Organizer: 2016 Annual Meeting the American Society for Cell Biology
  • Place of Presentation: San Francisco (USA)
  • Year and Date: 2016-12-03
  • Int'l Joint Research
• [Presentation] Amyloid-like fibril formation and biological activity of racemic fibrogenic peptides (2016)
  • Author(s): F. Katagiri, K. Mori, K. Hozumi, Y. Kikkawa, M. Nomizu
  • Organizer: 第53回ペプチド討論会
  • Place of Presentation: 京都
  • Year and Date: 2016-10-26
• [Presentation] Biomaterials with peptide-polyion complex matrices (2016)
  • Author(s): K. Nakamura, J. Kumai, C. Fujimori, F. Katagiri, K. Hozumi, Y. Kikkawa, M. Nomizu
  • Organizer: 第53回ペプチド討論会
  • Place of Presentation: 京都
  • Year and Date: 2016-10-26
• [Presentation] Identification of integrin binding site in human laminin alpha5 G domain (2016)
  • Author(s): J. Kumai, A. Nakagawa, Y. Lin, F. Katagiri, K. Hozumi, Y. Kikkawa, M. Nomizu
  • Organizer: 第53回ペプチド討論会
  • Place of Presentation: 京都
  • Year and Date: 2016-10-26
• [Presentation] ペプチド-キトサンマトリックスを用いたインテグリン-インテグリンクロストークの同定 (2016)
  • Author(s): 保住 建太郎、榎本 沙也香、片桐 文彦、吉川 大和、野水 基義
  • Organizer: 第64回高分子討論会
  • Place of Presentation: 横浜
  • Year and Date: 2016-09-14
• [Presentation] ペプチドーポリイオンコンプレックスマトリックスを用いたバイオマテリアル (2016)
  • Author(s): 中村 亨太郎、熊井 準、藤森 能、片桐 文彦、保住 建太郎、吉川 大和、野水 基義
  • Organizer: 第64回高分子討論会
  • Place of Presentation: 横浜
  • Year and Date: 2016-09-14
• [Presentation] Effect of racemic amyloidogenic peptides on phospholylation of focal adhesion kinase (2016)
  • Author(s): F. Katagiri, K. Mori, K. Hozumi, Y. Kikkawa, M. Nomizu
  • Organizer: 34th Europian Peptide symposium
  • Place of Presentation: Leipzig (Germany)
  • Year and Date: 2016-09-04
  • Int'l Joint Research
• [Presentation] Identification of biologically active sequences from human laminin alpha5 G chain domain (2016)
  • Author(s): J. Kumai, Y. Lin, A. Nakagawa, F. Katagiri, K. Hozumi, Y. Kikkawa, M. Nomizu
  • Organizer: The 14th Chinese International Peptide Symposium & the 5th Asia-pacific International Peptide Sympoisum
  • Place of Presentation: Nanjin (China)
  • Year and Date: 2016-07-04
  • Int'l Joint Research
• [Presentation] Identification of homologous bioactive sequences in laminin beta chains using peptide-chitosan matrices (2016)
  • Author(s): Y. Gu, K. Hozumi, J. Kumai, F. Katagiri, Y. Kikkawa, M. Nomizu
  • Organizer: The 14th Chinese International Peptide Symposium & the 5th Asia-pacific International Peptide Sympoisum
  • Place of Presentation: Nanjin (China)
  • Year and Date: 2016-07-04
  • Int'l Joint Research
• [Presentation] ペプチド高分子多糖マトリックスを用いた線維芽細胞接着活性を促進するインテグリンクロストークの同定 (2016)
  • Author(s): 保住 建太郎、榎本 沙也香、片桐 文彦、吉川 大和、野水 基義
  • Organizer: 第48回日本結合組織学会学術大会
  • Place of Presentation: 長崎
  • Year and Date: 2016-06-24
• [Presentation] 高分子多糖マトリックスを用いたラミニンα5 鎖Gドメイン生物活性部位の同定 (2016)
  • Author(s): 熊井 準、中川 生彩、林 怡辰、片桐 文彦、保住 建太郎、吉川 大和、野水 基義
  • Organizer: 第48回日本結合組織学会学術大会
  • Place of Presentation: 長崎
  • Year and Date: 2016-06-24
• [Presentation] ペプチドーポリイオンコンプレックスマトリックスの作成と生物活性 (2016)
  • Author(s): 中村 亨太郎、熊井 準、藤森 能、片桐 文彦、保住 建太郎、吉川 大和、野水 基義
  • Organizer: 第48回日本結合組織学会学術大会
  • Place of Presentation: 長崎
  • Year and Date: 2016-06-24
• [Presentation] ラミニンα5 鎖 short arm 領域の血管内皮細胞接着に関わるアミノ酸配列の同定 (2016)
  • Author(s): 菅原 由美香、原島 望、藤井 翔悟、片桐 文彦、保住 建太郎、野水 基義、吉川 大和
  • Organizer: 第48回日本結合組織学会学術大会
  • Place of Presentation: 長崎
  • Year and Date: 2016-06-24
• [Presentation] ROCK経路を介したラミニン-511に対する細胞接着の抑制と細胞運動の促進 (2016)
  • Author(s): 原島 望、碇 和樹、藤井 翔悟、片桐 文彦、保住 建太郎、野水 基義、吉川 大和
  • Organizer: 第48回日本結合組織学会学術大会
  • Place of Presentation: 長崎
  • Year and Date: 2016-06-24
• [Presentation] 基底膜の機能解明からバイオマテリアルの創製へ (2016)
  • Author(s): 吉川 大和、保住 建太郎、片桐 文彦、野水 基義
  • Organizer: 第48回日本結合組織学会学術大会
  • Place of Presentation: 長崎
  • Year and Date: 2016-06-24
• [Presentation] ラミニンγ1鎖配列由来生物活性ペプチドC16の構造活性相関 (2016)
  • Author(s): 片桐 文彦、山田 里実、保住 建太郎、吉川 大和、野水 基義
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-26
• [Presentation] ペプチド-アルギン酸マトリックスを用いたヒトラミニンα5Gドメイン活性配列の同定 (2016)
  • Author(s): 熊井 準、中川 生彩、片桐 文彦，保住 建太郎，吉川 大和，野水 基義
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-26
• [Presentation] Identification of active sequences in N-terminal region of laminin alpha5 involving endothelial cell attachment (2015)
  • Author(s): S. Fujii, N. Harashima, K. Ikari, F. Katagiri, K. Hozumi, M. Nomizu, Y. Kikkawa
  • Organizer: 2015 cell biology ascb annual meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2015-12-12
  • Int'l Joint Research
• [Presentation] Identification of active sequences from human laminin alpha5 chain G domain (2015)
  • Author(s): J. Kumai, A. Nakagawa, L. Yichen, F. Katagiri, K. Hozumi, Y. Kikkawa, M. Nomizu
  • Organizer: 2015 cell biology ascb annual meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2015-12-12
  • Int'l Joint Research
• [Presentation] Down-regulation of cell adhesion via ROCK pathway promotes tumor cell migration on laminin-511 (2015)
  • Author(s): N. Harashima, S. Fujii, K. Ikari, F. Katagiri, K. Hozumi, M. Nomizu, Y. Kikkawa
  • Organizer: 2015 cell biology ascb annual meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2015-12-12
  • Int'l Joint Research
• [Presentation] Laminin beta chain derived peptide conjugated chitosan matrices promote cell attachment and spreading (2015)
  • Author(s): Y. Gu, J. Kumai, F. Katagiri, K. Hozumi, Y. Kikkawa, M. Nomizu
  • Organizer: 2015 cell biology ascb annual meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2015-12-12
  • Int'l Joint Research
• [Presentation] Development of PRARI and RGD motif from fibronectin conjugated chitosan matrix binds integrin alpha4beta1 and heparin (2015)
  • Author(s): K. Hozumi, H. Hori, M. Miyagi, F. Katagiri, Y. Kikkawa, M. Nomizu
  • Organizer: 2015 cell biology ascb annual meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2015-12-12
  • Int'l Joint Research
• [Presentation] Structure-activity relationship study for biologically active peptides C16 (KAFDITYVRLKF) derived from mouse laminin gamma1 chain sequence (2015)
  • Author(s): F. Katagiri, S. Yamada, K. Hozumi, Y. Kikkawa, M. Nomizu
  • Organizer: 2015 cell biology ascb annual meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2015-12-12
  • Int'l Joint Research
• [Presentation] Screening of biological active peptides from human laminin alpha5 chain G domain (2015)
  • Author(s): J. Kumai, A. Nakagawa, L. Yichen, F. Katagiri, K. Hozumi, Y. Kikkawa, M. Nomizu
  • Organizer: 第52回ペプチド討論会
  • Place of Presentation: 平塚
  • Year and Date: 2015-11-16
• [Presentation] The cell attachment and spreading activities of laminin beta chains derived biologically active peptides conjugated chitosan matrices (2015)
  • Author(s): Y. Gu, J. Kumai, F. Katagiri, K. Hozumi, Y. Kikkawa, M. Nomizu
  • Organizer: 第52回ペプチド討論会
  • Place of Presentation: 平塚
  • Year and Date: 2015-11-16
• [Presentation] Identification of amino acids sequences in short arm region of laminin alpha5 involving endothelial cell attachment (2015)
  • Author(s): S. Fujii, A. Nakagawa, N. Harashima, K. Ikari, F. Katagiri, K. Hozumi, Y. Kikkawa, M. Nomizu
  • Organizer: 第52回ペプチド討論会
  • Place of Presentation: 平塚
  • Year and Date: 2015-11-16
• [Presentation] フィブロネクチンの機能を模倣したペプチド-キトサンマトリックスの開発 (2015)
  • Author(s): 保住 建太郎、堀 陽奈、中村 亨太郎、宮城 麻里、片桐 文彦、吉川 大和、野水 基義
  • Organizer: 第64回高分子討論会
  • Place of Presentation: 仙台
  • Year and Date: 2015-09-15
• [Presentation] ラミニン-511上における癌細胞の運動促進メカニズム (2015)
  • Author(s): 原島 望、藤井 翔吾、碇 和樹、片桐 文彦、保住 建太郎、野水 基義、吉川 大和
  • Organizer: 第3回 MatriCellフォーラム
  • Place of Presentation: 津
  • Year and Date: 2015-09-12
• [Presentation] Tumor cell migration on laminin-511 is promoted through the receptor binding reduced with PMA (2015)
  • Author(s): K. Hozumi, H. Hori, M. Miyagi, F. Katagiri, Y. Kikkawa, M. Nomizu
  • Organizer: 9th International Conference on Proteoglycans and 10th Pan-Pacific Connective Tissue Societies Symposium
  • Place of Presentation: ソウル、韓国
  • Year and Date: 2015-08-24
  • Int'l Joint Research
• [Presentation] フィブロネクチン由来新規インテグリンα4β1結合ペプチドを用いたペプチド-キトサンマトリックスの開発 (2015)
  • Author(s): 保住 建太郎、堀 陽奈、宮城 麻里、片桐 文彦、吉川 大和、野水 基義
  • Organizer: 第47回日本結合組織学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2015-05-15
• [Presentation] インテグリンに結合するペプチドA2G10を固定化した高分子多糖マトリックスの生物活性に及ぼすリンカーの効果 (2015)
  • Author(s): 熊井 準、保住 建太郎、片桐 文彦、吉川 大和、野水 基義
  • Organizer: 第47回日本結合組織学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2015-05-15
• [Presentation] MDCK細胞のcyst形成におけるラミニン-511の役割 (2015)
  • Author(s): 碇 和樹、藤井 翔吾、片桐 文彦、保住 建太郎、吉川 大和、野水 基義
  • Organizer: 第47回日本結合組織学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2015-05-15
• [Presentation] ラミニン-511に対する細胞接着の抑制と細胞運動の促進 (2015)
  • Author(s): 藤井 翔吾、碇 和樹、片桐 文彦、保住 建太郎、吉川 大和、野水 基義
  • Organizer: 第47回日本結合組織学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2015-05-15
• [Book] 医療・診断をささえるペプチド科学 -細胞接着モチーフ（ラミニン）- (2017)
  • Author(s): 保住建太郎、熊井準、野水基義
  • Total Pages: 6
  • Publisher: 株式会社シーエムシー
  • ISBN: 9784781312675