| Project/Area Number |
15K01327
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Daimon Masao 東京大学, 医学部附属病院, 講師 (80343094)
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| Co-Investigator(Kenkyū-buntansha) |
川田 貴之 東京大学, 医学部附属病院, 助教 (20532526)
中尾 倫子 東京大学, 医学部附属病院, 助教 (30597216)
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| Research Collaborator |
HIROKAWA Megumi 東京大学, 医学附属病院, 特任臨床医
KIMURA Koichi 東京大学, 医科学研究所附属病院, 特任助教
SAWADA Naoko 東京大学, 医学系大学院, 大学院生
ISHIWATA Junpei 東京大学, 医学系大学院, 大学院生
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Echocardiography / Imaging / Valvular heart disease / 弁膜症 / 心エコー図 / 僧帽弁閉鎖不全症 / 3次元心エコー / 弁逆流 / 僧帽弁 / 虚血性心疾患 |
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| Outline of Final Research Achievements |
Reduced coaptation of mitral valve (MV) is a risk for developing functional mitral regurgitation (MR). We determined if MV leaflet area is associated with MV coaptation zone-area, and to identify the clinical factors associated with mitral leaflet size and coaptation-zone area in patients with the normal left ventricle (LV) systolic function and size, by real-time 3D echocardiography. In 175 patients with normal LV size and ejection fraction, there was a significant relationship between MV leaflet and coaptation-zone areas. MV leaflet area was strongly associated with body surface area (BSA) (r =0.907, p<0.001) rather than LV size and age. In 68 patients, we also found that MV coaptation-zone area/BSA was independently associated with the severity of atherosclerosis assessed by cardio-ankle vascular index (CAVI) (r=-0.964, p<0.001), suggesting atherosclerotic change might reduce MA area resulting in generation of functional MR.
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