Failure of compensatory elongation of mitral valve: A novel approach for ischemic mitral regurgitation using 3D echocardiography

• Project/Area Number: 15K01327
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical systems
• Research Institution: The University of Tokyo
• Principal Investigator: Daimon Masao 東京大学, 医学部附属病院, 講師 (80343094)
• Co-Investigator(Kenkyū-buntansha): 川田 貴之 東京大学, 医学部附属病院, 助教 (20532526) ; 中尾 倫子 東京大学, 医学部附属病院, 助教 (30597216)
• Research Collaborator: HIROKAWA Megumi 東京大学, 医学附属病院, 特任臨床医 ; KIMURA Koichi 東京大学, 医科学研究所附属病院, 特任助教 ; SAWADA Naoko 東京大学, 医学系大学院, 大学院生 ; ISHIWATA Junpei 東京大学, 医学系大学院, 大学院生
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: Echocardiography / Imaging / Valvular heart disease / 弁膜症 / 心エコー図 / 僧帽弁閉鎖不全症 / 3次元心エコー / 弁逆流 / 僧帽弁 / 虚血性心疾患

Outline of Final Research Achievements

Reduced coaptation of mitral valve (MV) is a risk for developing functional mitral regurgitation (MR). We determined if MV leaflet area is associated with MV coaptation zone-area, and to identify the clinical factors associated with mitral leaflet size and coaptation-zone area in patients with the normal left ventricle (LV) systolic function and size, by real-time 3D echocardiography. In 175 patients with normal LV size and ejection fraction, there was a significant relationship between MV leaflet and coaptation-zone areas. MV leaflet area was strongly associated with body surface area (BSA) (r =0.907, p<0.001) rather than LV size and age. In 68 patients, we also found that MV coaptation-zone area/BSA was independently associated with the severity of atherosclerosis assessed by cardio-ankle vascular index (CAVI) (r=-0.964, p<0.001), suggesting atherosclerotic change might reduce MA area resulting in generation of functional MR.

Research Products

• [Journal Article] Echocardiographic assessment of right ventricular function in routine practice: Which parameters are useful to predict one-year outcome in advanced heart failure patients with dilated cardiomyopathy? (2017)
  • Author(s): Takayuki Kawata, Masao Daimon, Koichi Kimura, Tomoko Nakao, Seitetsu L. Lee, Megumi Hirokawa, Tomoko S. Kato, Masafumi Watanabe, Yutaka Yatomi, Issei Komuro
  • Journal Title: Journal of Cardiology Volume: 印刷中 Issue: 4 Pages: 316-322
  • DOI: 10.1016/j.jjcc.2017.02.007
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Beneficial effect of body weight control on left ventricular diastolic function in the general population: an analysis of longitudinal data from a health check-up clinic (2017)
  • Author(s): Lee Seitetz C、Daimon Masao、Di Tullio Marco R、Homma Shunichi、Hasegawa Takahiro、Chiou Sy Han、Nakao Tomoko、Hirokawa Megumi、Mizuno Yoshiko、Yatomi Yutaka、Yamazaki Tsutomu、Komuro Issei
  • Journal Title: European Heart Journal - Cardiovascular Imaging Volume: 19 Issue: 2 Pages: 136-142
  • DOI: 10.1093/ehjci/jex219
  • Peer Reviewed
• [Journal Article] Reconsideration of Inferior Vena Cava Parameters for Estimating Right Atrial Pressure in an East Asian Population ― Comparative Simultaneous Ultrasound-Catheterization Study ― (2017)
  • Author(s): Takayuki Kawata, Masao Daimon, Seitetsu L. Lee, Koichi Kimura, Naoko Sawada, Shuo-Ju Chiang, Keitaro Mahara, Takeshi Okubo, Tomoko Nakao, Megumi Hirokawa, Boqing Xu, Tomoko S. Kato, Masafumi Watanabe, Yutaka Yatomi, Issei Komuro
  • Journal Title: Circulation Journal Volume: 81 Issue: 3 Pages: 346-352
  • DOI: 10.1253/circj.CJ-16-0916
  • NAID: 130005242992
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Disaster Victim Identification using Orthopedic Implants in the 2011 East-Japan Earthquake and Tsunami (2017)
  • Author(s): Numata N, Makinae H, Yoshida W, Daimon M, Murakami H
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 241 Issue: 3 Pages: 219-223
  • DOI: 10.1620/tjem.241.219
  • NAID: 130005461074
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access
• [Journal Article] Estrogen variation during the menstrual cycle does not influence left ventricular diastolic function and untwisting rate in premenopausal women. (2017)
  • Author(s): Hirose K, Daimon M, Miyazaki S, Chiang SJ, Morimoto-Ichikawa R, Maruyama M, Kawata T, Ohmura H, Daida H.
  • Journal Title: Journal of Cardiology Volume: 69 Issue: 1 Pages: 389-393
  • DOI: 10.1016/j.jjcc.2016.09.008
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Relationship of Left Ventricular Diastolic Function to Obesity and Overweight in a Japanese Population With Preserved Left Ventricular Ejection Fraction (2016)
  • Author(s): Lee SL, Daimon M, Di Tullio MR, Homma S, Nakao T, Kawata T, Kimura K; Shinozak T, Hirokawa M, Kato T, Mizuno Y, Watanabe M, Yatomi Y, Yamazaki T, Komuro I.
  • Journal Title: Circulation Journal Volume: 80 Issue: 9 Pages: 1951-1956
  • DOI: 10.1253/circj.CJ-16-0381
  • NAID: 130005406872
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Cardiac aging phenomenon and its clinical features by echocardiography. (2016)
  • Author(s): Xu B, Daimon M.
  • Journal Title: Journal of echocardiography Volume: 14 Issue: 4 Pages: 139-145
  • DOI: 10.1007/s12574-016-0292-6
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Factors Influencing Left Atrial Volume in a Population with Preserved Ejection Fraction: Left Ventricular Diastolic Dysfunction or Clinical Factors? (2016)
  • Author(s): Lee SL, Daimon M, Nakao T, Singer DE, Shinozaki T, Kawata T, Kimura K, Hirokawa M, Kato TS, Mizuno Y, Watanabe M, Yatomi Y, Yamazaki T, Komuro I.
  • Journal Title: Journal of Cardiology Volume: 68 Issue: 4 Pages: 275-81
  • DOI: 10.1016/j.jjcc.2016.02.003
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 僧帽弁閉鎖不全におけるカテーテル治療。 (2016)
  • Author(s): 廣瀬邦章、大門雅夫
  • Journal Title: 成人病と生活習慣病 Volume: 46 Pages: 1023-1030
• [Journal Article] 現代における大動脈弁狭窄症の病像とは (2016)
  • Author(s): 大門雅夫
  • Journal Title: 心臓 Volume: 48 Pages: 1-9
• [Journal Article] Significance of Coronary Artery Disease and Left Ventricular Afterload in Unoperated Asymptomatic Aortic Stenosis (2016)
  • Author(s): Shibayama K , Daimon M, Watanabe H, Kawata T, Miyazaki S, Morimoto-Ichikawa R, Maruyama M, Chiang SJ, Miyauchi K, Daida H.
  • Journal Title: Circulation Journal Volume: 80 Issue: 2 Pages: 519-525
  • DOI: 10.1253/circj.CJ-15-0876
  • NAID: 130005120920
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Presentation] Left Ventricular Ejection Fraction is Essential for Assessing Pathophysiology of Heart Failure (2018)
  • Author(s): 大門雅夫
  • Organizer: 日本循環器病学会
  • Int'l Joint Research / Invited
• [Presentation] Mitral Leaflets Coaptation Zone Area is Associated with the Severity of Atherosclerosis Assessed by CAVI: Real-time 3D Echocardiographic Analysis (2018)
  • Author(s): Boqing Xu、Masao Daimon、Takayuki Kawata、 Tomoko Nakao、Megumi Hirokawa、Naoko Sawada、 Jumpei Ishiwata、Hiroyuki Kiriyama、Koichi Kimura、Masafumi Watanabe、Issei Komuro、Yutaka Yatomi
  • Organizer: 日本循環器病学会
  • Int'l Joint Research
• [Presentation] Clinical Factors Associated with Left Ventricular Reverse Remodeling in Non-ischemic Dilated Cardiomyopathy (2018)
  • Author(s): 石渡惇平、川田貴之、大門雅夫、木村公一、中尾倫子、廣川愛美、澤田直子、徐博卿、Purevsuren Munkhtuul、網谷英介、波多野将、加藤倫子、渡辺昌文、小室一成
  • Organizer: 日本循環器病学会
  • Int'l Joint Research
• [Presentation] Clinical factors associated with mitral valve leaflet and coaptation zone areas: Real-time 3D echocardiographic analysis (2017)
  • Author(s): Boqing Xu, Masao Daimon, Takayuki Kawata, Koichi Kimura, Tomoko Nakao, Megumi Hirokawa, Naoko Sawada, Yuko Yamanaka, Masafumi Watanabe, Issei Komuro, Yutaka Yatomi
  • Organizer: 日本循環器病学会
  • Place of Presentation: 金沢ANAホテル（金沢）
  • Year and Date: 2017-03-17
  • Int'l Joint Research
• [Presentation] Association among plasma adiponectin, visceral fat and left ventricular diastolic function in the general population (2017)
  • Author(s): Naoko Sawada, Masao Daimon, Takayuki Kawata, Koichi Kimura, Tomoko Nakao, Megumi Hirokawa, Boqing Xu, Masafumi Watanabe, Issei Komuro
  • Organizer: 日本循環器病学会
  • Place of Presentation: 金沢ANAホテル（金沢）
  • Year and Date: 2017-03-17
  • Int'l Joint Research
• [Presentation] Clinical manifestations of non-ischemic dilated cardiomyopathy with right ventricular dysfunction (2017)
  • Author(s): Ishiwata J, Kawata T, Daimon M, Kimura K, Nakao N, Hirokawa M, Sawada N, Xu B, Watanabe M, Yatomi Y, Komuro I
  • Organizer: Euro Eho Imaging
  • Int'l Joint Research
• [Presentation] Comparison between invasive mean pulmonary artery pressure and Doppler derived peak tricuspid regurgitation pressure gradient (2017)
  • Author(s): Sawada N, Kawata T, Daimon M, Kimura K, Nakao N, Hirokawa M, Ishiwata J, Xu B, Watanabe M, Yatomi Y, Komuro I
  • Organizer: Euro Eho Imaging
  • Int'l Joint Research
• [Presentation] Reconsidering of inferior vena cava parameters for estimating right atrial pressure: a comparative simultaneous ultrasound-catheterization study (2016)
  • Author(s): Sawada N, Kawata T, Daimon M, Kimura K, Nakao T, Chiang SJ, Mahara K, Okubo T, Yatomi Y, Komuro I
  • Organizer: Euro Eho Imaging
  • Place of Presentation: Leipzig convention center (Leipzig, Germany)
  • Year and Date: 2016-12-07
  • Int'l Joint Research
• [Presentation] 高齢者・超高齢者における心エコー検査 (2016)
  • Author(s): 大門雅夫
  • Organizer: 日本超音波医学会第89回学術集会
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2016-05-26
  • Int'l Joint Research / Invited
• [Presentation] Postoperative Change of Right Ventricular Systolic Function in Patients Undergoing Surgery for Isolated Severe Tricuspid Regurgitation (2016)
  • Author(s): Megumi Hirokawa, Masao Daimon, Keitaro Mahara, Hajime Kim, Shuichiro Takanashi, Yasutaka Hirata, Haruo Yamauchi, Hitonobu Tomoike, Issei Komuro
  • Organizer: 第80回日本循環器病学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Book] ナース・メディカルスタッフのための循環器レクチュア第4版 (2018)
  • Author(s): 齋藤宣彦、大門雅夫
  • Total Pages: 220
  • Publisher: 文光堂
  • ISBN: 9784830644634
• [Remarks] 東京大学循環器内科 心エコー研究
  • URL: https://cardiovasc.m.u-tokyo.ac.jp/clinical/echocardiography/study