Impact evaluation of magnetic fields toward a target chemotherapy

• Project/Area Number: 15K01328
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical systems
• Research Institution: Kanazawa University
• Principal Investigator: Kakikawa Makiko 金沢大学, 電子情報学系, 准教授 (10359713)
• Co-Investigator(Kenkyū-buntansha): 山田 外史 金沢大学, 環日本海域環境研究センター, 連携研究員 (80019786)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 交流磁場 / がん細胞 / 薬剤作用 / 薬剤効果

Outline of Final Research Achievements

We have constructed a magnetic fields exposure system for long-term experiments with human cells, and investigated the time dependence of magnetic fields exposure influence on drug potency. The results indicated that the potency of anticancer drug, cisplatin to human lung cancer cells was increased significantly by exposure to magnetic fields for 0.5 ~4 h, not for 24 h or more. Furthermore, our results suggested that the magnetic fields enhance the potency of anticancer drugs to not only lung cancer cells but also human hepatoma cells.

Research Products

• [Journal Article] Concentration and Viability of Bacterial Aerosols Associated with Weather in Asian Continental Outflow: Current Understanding (2017)
  • Author(s): Zhang Daizhou、Murata Kotaro、Hu Wei、Yuan Hongli、Li Weilin、Matsusaki Hiromi、Kakikawa Makiko
  • Journal Title: Aerosol Science and Engineering Volume: 1 Issue: 2 Pages: 66-77
  • DOI: 10.1007/s41810-017-0008-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cell concentration, viability and culture composition of airborne bacteria during a dust event in Beijing, (2016)
  • Author(s): Yuan H, Zhang D, Shi Y, Li B, Yang J, Yu X, Chen N, Kakikawa M,
  • Journal Title: Journal of Environmental Sciences Volume: - Pages: 33-40
  • DOI: 10.1016/j.jes.2016.03.033
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effects of different temperature treatments on biological ice (2016)
  • Author(s): Hara, K., T. Maki, M. Kakikawa, F. Kobayashi, A. Matsuki
  • Journal Title: Atmospheric Environment Volume: 140 Pages: 415-419
  • DOI: 10.1016/j.atmosenv.2016.06.011
  • Peer Reviewed
• [Journal Article] Variations of ice nuclei concentrahttps://www-kofu.jsps.go.jp/kofu1/images/title_img1.giftion induced by rain and snowfall 1 within a local forested site in Japan (2016)
  • Author(s): K. Hara, T. Maki, F. Kobayashi, M. Kakikawa, M. Wada, A. Matsuki
  • Journal Title: Atmospheric Environmen Volume: 127 Pages: 1-5
  • DOI: 10.1016/j.atmosenv.2015.12.009
  • Peer Reviewed
• [Journal Article] Evaluation of the toxicity of a Kosa (Asian duststorm) event from view of food poisoning: observation of Kosa cloud behavior and real-time PCR analyses of Kosa bioaerosols during May 2011 in Kanazawa, Japan (2015)
  • Author(s): 2.Kobayashi F, Iwata K, Maki T, Kakikawa M, Higashi T, Yamada M, Ichinose T, Iwasaka Y
  • Journal Title: Air Quality, Atmosphere and health Volume: in press Issue: 1 Pages: 3-14
  • DOI: 10.1007/s11869-015-0333-8
  • Peer Reviewed / Open Access
• [Journal Article] Increase in High-Frequency Magnetic Fields due to Parallel Coils Added to Applicator for Hyperthermia Therapy (2015)
  • Author(s): Yamada S, Ikehata Y, Hayashi T, Ueno T, Kakikawa M,
  • Journal Title: Journal of the Magnetics Society of Japan Volume: 39 Issue: 2 Pages: 80-84
  • DOI: 10.3379/msjmag.1503R006
  • NAID: 130004951239
  • ISSN: 1882-2924, 1882-2932
  • Peer Reviewed
• [Journal Article] Vertical distribution of airborne bacterial communities in an Asian dust downwind area, Noto Peninsula (2015)
  • Author(s): Maki T., Hara K., Kobayashi F., Kurosaki Y., Kakikawa M., Matsuki A., Chen B., Shi G., Hasegawa H., Iwasaka Y.
  • Journal Title: Atmospheric Environment Volume: 119 Pages: 282-293
  • DOI: 10.1016/j.atmosenv.2015.08.052
  • NAID: 120005851363
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Bioprocess of Kosa bioaerosols: effect of 1 ultraviolet radiation on airborne bacteria within Kosa (Asian dust) (2015)
  • Author(s): 3.Kobayashi F, Maki T, Kakikawa M, Yamada M, Puspitasari F, Iwasaka Y
  • Journal Title: Journal of Bioscience and Bioengineering Volume: 199 Issue: 5 Pages: 570-579
  • DOI: 10.1016/j.jbiosc.2014.10.015
  • Peer Reviewed / Open Access
• [Presentation] 多剤耐性がん細胞における抗がん剤作用とその取り込み量への交流磁界影響評価 (2017)
  • Author(s): 遠藤裕哉，松居大輔，山田外史，柿川真紀子
  • Organizer: 第41回日本磁気学会学術講演会
• [Presentation] ヒトがん細胞への抗がん剤取込みにおける交流磁界影響 (2016)
  • Author(s): 松居大輔、牛丸透、山田外史、柿川真紀子
  • Organizer: 平成28年 電気学会全国大会
  • Place of Presentation: 東北大学
  • Year and Date: 2016-03-18
• [Presentation] 交流磁界曝露による細胞への抗がん剤取り込み量および細胞生存率への影響 (2016)
  • Author(s): 松居大輔，柿川真紀子，山田外史
  • Organizer: 第40回日本磁気学会学術講演会
  • Place of Presentation: 金沢大学
• [Presentation] 多剤耐性を有するヒトがん細胞への抗がん剤作用に対する交流磁界影響 (2016)
  • Author(s): 大野洋靖，柿川真紀子，山田外史
  • Organizer: 第40回日本磁気学会学術講演会
  • Place of Presentation: 金沢大学
• [Presentation] 交流磁界曝露による抗がん剤ドキソルビシン作用への影響 (2015)
  • Author(s): 松居大輔、牛丸透、萩原章希、山田外史、柿川真紀子
  • Organizer: 平成27年 電気学会 基礎・材料・共通部門大会
  • Place of Presentation: 金沢大学
  • Year and Date: 2015-09-18
• [Presentation] 肺がん細胞へのドキソルビシン作用に対する交流磁界曝露影響 (2015)
  • Author(s): 松居大輔、牛丸透、萩原章希、山田外史、柿川真紀子
  • Organizer: 第39回 日本磁気学会学術講演会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2015-09-08