A comparative study of the anti-epileptic efficacy of neuromodulation by brain cooling, electrical stimulation, and intracortical drug administration.
| Project/Area Number |
15K01332
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Medical systems
|
|---|
| Research Institution | Yamaguchi University |
|---|
Principal Investigator |
INOUE Takao 山口大学, 医学部附属病院, 講師 (80513225)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | てんかん / 局所脳冷却 / ニューロモデュレーション |
|---|
| Outline of Final Research Achievements |
In this study, we compared the anti-epileptic effect of each neuromodulation by temperature, electricity, and drug. To achieve stimulation of the brain by three neuromodulators with one device, we created a new device that can apply three modulations with one device. A cranial window was made on the right somatosensory-motor cortex of anesthetized rats, and this device was attached to the brain surface. I induced Epileptiform discharges by intracortical administration of Penicillin G via a hole provided in the central part of the device. Then the inhibitory effect of Epileptiform Discharges by each neuromodulation was compared. As a result, the effect of electrical stimulation varied considerably, while inhibitory effects by cooling and drugs were complementary. It is suggested that the techniques based on a combination of neuromodulation can improve the treatment effects for intractable epilepsy.
|
Report
(4 results)
Research Products
(3 results)
