| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In this study, we compared the anti-epileptic effect of each neuromodulation by temperature, electricity, and drug. To achieve stimulation of the brain by three neuromodulators with one device, we created a new device that can apply three modulations with one device. A cranial window was made on the right somatosensory-motor cortex of anesthetized rats, and this device was attached to the brain surface. I induced Epileptiform discharges by intracortical administration of Penicillin G via a hole provided in the central part of the device. Then the inhibitory effect of Epileptiform Discharges by each neuromodulation was compared. As a result, the effect of electrical stimulation varied considerably, while inhibitory effects by cooling and drugs were complementary. It is suggested that the techniques based on a combination of neuromodulation can improve the treatment effects for intractable epilepsy.
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