| Project/Area Number |
15K01342
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Yokohama College of Pharmacy |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
岩瀬 由未子 横浜薬科大学, 薬学部, 講師 (00521882)
梅村 晋一郎 東北大学, 医工学研究科, 教授 (20402787)
弓田 長彦 横浜薬科大学, 薬学部, 教授 (40191481)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 超音波 / 音響化学 / 分子標的薬 / CD20抗原 / 音響化学療法 / ポルフィーマナトリウム / 水溶性フラーレン / 活性酸素種 / レザフィリン / 分子標的治療薬 / セツキシマブ |
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| Outline of Final Research Achievements |
In this study, the sonodynamically induced antitumor effect of Rituximab (RIT) was investigated in CD20-positive human Burkitt's lymphoma-derived cell line, Raji cells. Apoptosis was examined after the combination of SDT and RIT in HL-60 cells. Apoptosis was analyzed by cell morphology and caspase-3 activity. The cell damage induced by sonication was enhanced by two-fold in the presence of RIT. Histidine significantly inhibited this enhancement. This inhibitory effect suggests that the sonodynamically induced antitumor effect was mediated by sonodynamically generated reactive oxygen species. These results suggest that PHF is a potential sonosensitizer for sonodynamic treatment of solid tumors.
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