Application of the monitoring method of irradiation positions measuring bremsstrahlung for proton therapy
| Project/Area Number |
15K01349
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | National Institutes for Quantum and Radiological Science and Technology (2016-2018)
Japan Atomic Energy Agency (2015) |
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Principal Investigator |
Yamaguchi Mitsutaka 国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 放射線生物応用研究部, 主幹研究員(定常) (10375404)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ビームモニタリング / 粒子線がん治療 / 二次電子制動輻射 / モンテカルロシミュレーション / 可視化 / 陽子線治療 / ビームイメージング / 制動輻射 / 粒子線治療 / 電子制動輻射 |
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| Outline of Final Research Achievements |
We measured secondary electron bremsstrahlung emitted when proton beams were incident on a water phantom using a pinhole X-ray camera. Next, correlation between experimental and simulation results was confirmed using a Monte Carlo simulation environment that accurately incorporates emission distribution of secondary electron bremsstrahlung. Using this simulation environment, we studied a background reduction method. It was shown that the material of silver and tin or alloys based on them could significantly reduce the background by using the camera component, such as collimator and radiation shielding wall. Based on this result, We manufactured a prototype X-ray camera using silver alloy and tin for the collimator and the radiation shield, respectively. And performance evaluation was conducted.
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| Academic Significance and Societal Importance of the Research Achievements |
粒子線治療施設の大多数は陽子線施設が占めているため、本研究により本手法の適用範囲が大きく広がる。また、本研究により得られる知見は炭素線のバックグラウンド成分削減に関する研究にも役立つため、炭素線における制動輻射によるモニタリング手法の精緻化も加速される。さらに、イオンの体内深部位置をリアルタイムモニター可能になるため、照射位置のずれを治療中に修正できる可能性が生まれる。照射位置を治療照射終了後に確認することと、リアルタイムで照射位置を確認しながら治療することは、医療行為としての信頼性が本質的に異なるため、本手法は医療技術の信頼性を大幅に向上させる。
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Report
(5 results)
Research Products
(25 results)
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[Journal Article] Corrigendum: Beam range estimation by measuring bremsstrahlung (2012 Phys. Med. Biol. 57 2843)2016
Author(s)
Mitsutaka Yamaguchi, Kota Torikai, Naoki Kawachi, Hirofumi Shimada, Takahiro Satoh, Yuto Nagao, Shu Fujimaki, Motohide Kokubun, Shin Watanabe, Tadayuki Takahashi, Kazuo Arakawa, Tomihiro Kamiya and Takashi Nakano
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Journal Title
Physics in Medicine and Biology
Volume: 61
Issue: 9
Pages: 3638-3644
DOI
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Peer Reviewed
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[Presentation] Monte Carlo Simulation about detection of a gap across a carbon beam by measuring low-energy photons2015
Author(s)
山口 充孝, 長尾 悠人, 河地 有木, 藤巻 秀, 神谷 富裕, 鳥飼 幸太, 島田 博文, 菅井 裕之, 酒井 真理, 荒川 和夫, 中野 隆史
Organizer
第 31 回 PIXE シンポジウム in 高崎
Place of Presentation
原子力機構 高崎量子応用研究所（群馬県・高崎市）
Year and Date
2015-10-28
Related Report
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