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Application of the monitoring method of irradiation positions measuring bremsstrahlung for proton therapy

Research Project

Project/Area Number 15K01349
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical systems
Research InstitutionNational Institutes for Quantum and Radiological Science and Technology (2016-2018)
Japan Atomic Energy Agency (2015)

Principal Investigator

Yamaguchi Mitsutaka  国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 放射線生物応用研究部, 主幹研究員(定常) (10375404)

Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsビームモニタリング / 粒子線がん治療 / 二次電子制動輻射 / モンテカルロシミュレーション / 可視化 / 陽子線治療 / ビームイメージング / 制動輻射 / 粒子線治療 / 電子制動輻射
Outline of Final Research Achievements

We measured secondary electron bremsstrahlung emitted when proton beams were incident on a water phantom using a pinhole X-ray camera. Next, correlation between experimental and simulation results was confirmed using a Monte Carlo simulation environment that accurately incorporates emission distribution of secondary electron bremsstrahlung. Using this simulation environment, we studied a background reduction method. It was shown that the material of silver and tin or alloys based on them could significantly reduce the background by using the camera component, such as collimator and radiation shielding wall. Based on this result, We manufactured a prototype X-ray camera using silver alloy and tin for the collimator and the radiation shield, respectively. And performance evaluation was conducted.

Academic Significance and Societal Importance of the Research Achievements

粒子線治療施設の大多数は陽子線施設が占めているため、本研究により本手法の適用範囲が大きく広がる。また、本研究により得られる知見は炭素線のバックグラウンド成分削減に関する研究にも役立つため、炭素線における制動輻射によるモニタリング手法の精緻化も加速される。さらに、イオンの体内深部位置をリアルタイムモニター可能になるため、照射位置のずれを治療中に修正できる可能性が生まれる。照射位置を治療照射終了後に確認することと、リアルタイムで照射位置を確認しながら治療することは、医療行為としての信頼性が本質的に異なるため、本手法は医療技術の信頼性を大幅に向上させる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (25 results)

All 2019 2018 2017 2016 2015 Other

All Journal Article (10 results) (of which Open Access: 2 results,  Peer Reviewed: 8 results,  Acknowledgement Compliant: 2 results) Presentation (13 results) (of which Int'l Joint Research: 5 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] 粒子線がん治療における治療ビーム軌跡の二次電子制動輻射による画像化2018

    • Author(s)
      山口充孝, 長尾悠人, 河地有木
    • Journal Title

      Isotope News

      Volume: 760 Pages: 6-9

    • Related Report
      2018 Annual Research Report
    • Open Access
  • [Journal Article] Imaging of monochromatic beams by measuring secondary electron bremsstrahlung for carbon-ion therapy using a pinhole x-ray camera2018

    • Author(s)
      Yamaguchi Mitsutaka、Nagao Yuto、Ando Koki、Yamamoto Seiichi、Sakai Makoto、Parajuli Raj Kumar、Arakawa Kazuo、Kawachi Naoki
    • Journal Title

      Physics in Medicine & Biology

      Volume: 63 Issue: 4 Pages: 045016-045016

    • DOI

      10.1088/1361-6560/aaa17c

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Estimation and correction of produced light from prompt gamma photons on luminescence imaging of water for proton therapy dosimetry2018

    • Author(s)
      Yabe Takuya、Komori Masataka、Toshito Toshiyuki、Yamaguchi Mitsutaka、Kawachi Naoki、Yamamoto Seiichi
    • Journal Title

      Physics in Medicine & Biology

      Volume: 63 Issue: 4 Pages: 04NT02-04NT02

    • DOI

      10.1088/1361-6560/aaa90c

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of a low-energy x-ray camera for the imaging of secondary electron bremsstrahlung x-ray emitted during proton irradiation for range estimation2017

    • Author(s)
      Ando Koki、Yamaguchi Mitsutaka、Yamamoto Seiichi、Toshito Toshiyuki、Kawachi Naoki
    • Journal Title

      Physics in Medicine and Biology

      Volume: 62 Issue: 12 Pages: 5006-5020

    • DOI

      10.1088/1361-6560/aa7166

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Monte Carlo simulation of photon emission below a few hundred kiloelectronvolts for beam monitoring in carbon ion therapy2017

    • Author(s)
      Mitsutaka Yamaguchi, Yuto Nagao, Takahiro Satoh, Hiroyuki Sugai, Makoto Sakai, Kazuo Arakawa, and Naoki Kawachi
    • Journal Title

      Review of Scientific Instruments

      Volume: 88 Issue: 1

    • DOI

      10.1063/1.4973986

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Secondary-electron-bremsstrahlung imaging for proton therapy2016

    • Author(s)
      Mitsutaka Yamaguchi, Yuto Nagao, Koki Ando, Seiichi Yamamoto, Toshiyuki Toshito, Jun Kataoka, Naoki Kawachi
    • Journal Title

      Nuclear Instruments and Methods in Physics Research A

      Volume: 833 Pages: 199-207

    • DOI

      10.1016/j.nima.2016.07.034

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Detection of a gas region in a human body across a therapeutic carbon beam by measuring low-energy photons2016

    • Author(s)
      Mitsutaka Yamaguchi, Yuto Nagao, Naoki Kawachi, Takahiro Satoh, Shu Fujimaki and Tomihiro Kamiya, Kota Torikai, Hirofumi Shimada, Hiroyuki Sugai, Makoto Sakai, Kazuo Arakawa and Takashi Nakano
    • Journal Title

      International Journal of PIXE

      Volume: 26 Issue: 01n02 Pages: 61-72

    • DOI

      10.1142/s0129083516500078

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Corrigendum: Beam range estimation by measuring bremsstrahlung (2012 Phys. Med. Biol. 57 2843)2016

    • Author(s)
      Mitsutaka Yamaguchi, Kota Torikai, Naoki Kawachi, Hirofumi Shimada, Takahiro Satoh, Yuto Nagao, Shu Fujimaki, Motohide Kokubun, Shin Watanabe, Tadayuki Takahashi, Kazuo Arakawa, Tomihiro Kamiya and Takashi Nakano
    • Journal Title

      Physics in Medicine and Biology

      Volume: 61 Issue: 9 Pages: 3638-3644

    • DOI

      10.1088/0031-9155/61/9/3638

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 粒子線治療における低エネルギー光子によるビームモニタリング手法の検討2016

    • Author(s)
      山口 充孝, 長尾 悠人
    • Journal Title

      JAEA-Review

      Volume: 2015-028 Pages: 121-122

    • Related Report
      2015 Research-status Report
    • Open Access
  • [Journal Article] Monitoring of positron using high-energy gamma camera for proton therapy2015

    • Author(s)
      山本 誠一, 歳藤 利行, 小森 雅孝, 森下 祐樹, 奥村 聡, 山口 充孝, 齋藤 勇一, 河地 有木, 藤巻 秀
    • Journal Title

      Annals of Nuclear Medicine

      Volume: 29 (3) Issue: 3 Pages: 268-275

    • DOI

      10.1007/s12149-014-0936-4

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] 二次電子制動輻射計測により得られる陽子線画像を用いた機械学習によるブラッグピークのずれの推定2019

    • Author(s)
      山口充孝, 長尾悠人, 河地有木
    • Organizer
      第66回応用物理学会春季学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Simulation study on imaging of a monochromatic carbon beam by measuring secondary electron bremsstrahlung2018

    • Author(s)
      Mitsutaka Yamaguchi, Yuto Nagao, Koki Ando, Seiichi Yamamoto, Makoto Sakai, Parajuli Raj Kumar, Kazuo Arakawa, Naoki Kawachi
    • Organizer
      Micro-Mini & Nano Dosimetry workshop and Innovative Technologies in Radiation Oncology 2018 (MMND-ITRO 2018)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of a low-energy X-ray camera for beam monitoring of particle therapy2017

    • Author(s)
      安藤 昇輝, 梶田 杏菜, 山本 誠一, 山口 充孝, 長尾 悠人, 歳藤 利行, 片岡 淳, 河地 有木
    • Organizer
      第113回日本医学物理学会学術大会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2017-04-13
    • Related Report
      2016 Research-status Report
  • [Presentation] Imaging of a monochromatic beam by measuring secondary electron bremsstrahlung for carbon-ion therapy2017

    • Author(s)
      Mitsutaka Yamaguchi, Yuto Nagao, Koki Ando, Seiichi Yamamoto, Makoto Sakai, Parajuli Raj Kumar, Kazuo Arakawa, Naoki Kawachi
    • Organizer
      2017 IEEE Nclear Science Symposium and Medical Imaging Conference
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of a low-energy X-ray camera for the imaging of secondary electron bremsstrahlung X-ray emitted during proton irradiation for range estimation2017

    • Author(s)
      Koki Ando, Anna Kajita, Seiichi Yamamoto, Mitsutaka Yamaguchi, Yuto Nagao, Toshiyuki Toshito, Jun Kataoka, Naoki Kawachi
    • Organizer
      2017 IEEE Nclear Science Symposium and Medical Imaging Conference
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 即発制動X線によるリアルタイムターゲッティング・システムの研究開発2017

    • Author(s)
      後藤紳一,山口充孝,渡部浩司,河地有木
    • Organizer
      第14回日本粒子線治療臨床研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] PHITS を用いた低エネルギー光子による粒子線治療ビームモニター手法の研究2017

    • Author(s)
      山口充孝
    • Organizer
      第13回PHITS研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] A simulation study on detection of a cavity across a therapeutic carbon beam using secondaty electron bremsstrahlung2016

    • Author(s)
      Mitsutaka Yamaguchi, Yuto Nagao, Takahiro Satoh, Tomihiro Kamiya, Makoto Sakai, Hiroyuki Sugai, Kazuo Arakawa, Naoki Kawachi
    • Organizer
      2016 IEEE Nuclear Science Symposium & Medical Imaging Conference
    • Place of Presentation
      Strasbourg (France)
    • Year and Date
      2016-10-29
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 粒子線の照射で発生する制動放射線の測定実験2016

    • Author(s)
      菅井 裕之, 酒井 真理, 長尾 悠人, 山口 充孝, 荒川 和夫
    • Organizer
      第28回放射線夏の学校(応用物理学会放射線分科会主催)
    • Place of Presentation
      リゾートイン白浜(千葉県・南房総市)
    • Year and Date
      2016-08-02
    • Related Report
      2016 Research-status Report
  • [Presentation] 低エネルギー光子測定による治療用炭素ビーム軌道上の空洞検出のシミュレーションによる評価2016

    • Author(s)
      山口 充孝, 長尾 悠人, 菅井 裕之, 酒井 真理, 河地 有木, 佐藤 隆博, 神谷 富裕, 藤巻 秀, 荒川 和夫, 鳴海 一雅
    • Organizer
      2016年第63回応用物理学会春季学術講演会
    • Place of Presentation
      東工大 大岡山キャンパス(東京都・目黒区)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Research-status Report
  • [Presentation] Detection of a Gap Across a Particle-Beam Track by Measuring 63-68 keV Photons2015

    • Author(s)
      Mitsutaka Yamaguchi, Yuto Nagao, Naoki Kawachi, Shu Fujimaki, Tomihiro Kamiya, Kota Torikai, Hirofumi Shimada, Kazuo Arakawa, Takashi Nakano
    • Organizer
      2015 IEEE Nucler Science Simposium & Medical Imaging Conference
    • Place of Presentation
      San Diego(米国)
    • Year and Date
      2015-10-31
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Monte Carlo Simulation about detection of a gap across a carbon beam by measuring low-energy photons2015

    • Author(s)
      山口 充孝, 長尾 悠人, 河地 有木, 藤巻 秀, 神谷 富裕, 鳥飼 幸太, 島田 博文, 菅井 裕之, 酒井 真理, 荒川 和夫, 中野 隆史
    • Organizer
      第 31 回 PIXE シンポジウム in 高崎
    • Place of Presentation
      原子力機構 高崎量子応用研究所(群馬県・高崎市)
    • Year and Date
      2015-10-28
    • Related Report
      2015 Research-status Report
  • [Presentation] シミュレーションで考慮されていない低エネルギー光子2015

    • Author(s)
      菅井 裕之, 平野 祥之, 酒井 真理, 山口 充孝, 長尾 悠人
    • Organizer
      原子衝突学会第 40 回年会
    • Place of Presentation
      首都大学東京 南大沢キャンパス(東京都・八王子市)
    • Year and Date
      2015-09-28
    • Related Report
      2015 Research-status Report
  • [Remarks] 粒子線の“リアルタイム見える化”を実現する新手法 ~飛跡に沿って発生する制動放射線に着目~

    • URL

      http://www.qst.go.jp/topics/itemid034-002091.html

    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] 粒子線モニタリング装置、粒子線モニタリング方法、粒子線モニタリングプログラム2017

    • Inventor(s)
      酒井真理、中野隆史、荒川和夫、菊地 美貴子、山口充孝 他
    • Industrial Property Rights Holder
      群馬大学、量子科学技術研究開発機構
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-215079
    • Filing Date
      2017
    • Related Report
      2017 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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