| Project/Area Number |
15K01357
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical engineering assessment
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| Research Institution | Japan Chemical Analysis Center |
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Principal Investigator |
Oshima Masumi 公益財団法人日本分析センター, その他部局等, 研究員(移行) (40354815)
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| Co-Investigator(Kenkyū-buntansha) |
熊田 博明 筑波大学, 医学医療系, 准教授 (30354913)
後藤 淳 新潟大学, 研究推進機構, 助教 (90370395)
伴場 滋 公益財団法人日本分析センター, その他部局等, 研究員(移行) (40544432)
畢 春蕾 公益財団法人日本分析センター, その他部局等, 研究員(移行) (80647321)
山口 友理恵 公益財団法人日本分析センター, その他部局等, 研究員(移行) (30639977)
森本 隆夫 公益財団法人日本分析センター, その他部局等, 研究員(移行) (40544359)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 荷電粒子放射化分析 / ホウ素中性子捕捉療法 / ガンマ線反同時計数 / がん治療 / 血液中ホウ素濃度測定 / 放射線シミュレーション / 非破壊分析 / BNCT / 血液分析 / B-10濃度 / ＧＥＡＮＴ / ガンマ線同時計数・反同時計数 |
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| Outline of Final Research Achievements |
Boron Neutron Capture Therapy (BNCT) is a radiotherapy for the treatment of intractable cancer. In BNCT precise determination of B-10 concentration in whole blood samples is crucial for control of the neutron irradiation time. We firstly apply Charged Particle Activation Analysis (CPAA) utilizing a proton beam to non-destructive and accurate determination of B-10 concentration. Short-lived 511 keV annihilation gamma-rays have turned out to disturb the quick determination. By a simulation calculation based on the GEANT 4.10.2 code we have derived an optimal configuration of gamma-ray detectors to reduce the 511 keV gamma-rays. We constructed the detector system comprising a Ge detector and a BGO (Bi4Ge3O12) scintillator. We performed an experiment utilizing a proton beam, which proved the system effective in reducing the background by a factor of 1/29-1/41. The technique contributes to a quick determination of B-10 concentration in whole blood samples in the order of hours.
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