Brain function analysis for neurobehavioral disability using IMZ SPECT and MRI diffusion imaging

• Project/Area Number: 15K01358
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Hokkaido University
• Principal Investigator: Ikoma Katsunori 北海道大学, 大学病院, 教授 (70202918)
• Co-Investigator(Kenkyū-buntansha): Tha KhinKhin 北海道大学, 大学病院, 特任講師 (20451445) ; 志賀 哲 北海道大学, 医学研究院, 准教授 (80374495)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 高次脳機能障害 / 脳外傷 / MRI拡散画像 / IMZ SPECT / 頭部外傷 / FMZ PET

Outline of Final Research Achievements

We performed imaging of 123-I-Iomazenil SPECT (IMZ SPECT) and MRI diffusion imaging for 11 patients with neurobehavioral disability due to traumatic brain injury. We evaluated by comparing Diffusion Spectrum Imaging(DSI), which is one of diffusion images, between the patient group and the healthy control. As a result, several abnormalities were detected including normal region by conventional MRI.
DSI may be able to visualize brain damage which can not be detected by conventional image inspection. We will analyze the relationship between IMZ SPECT and other diffusion images.

Research Products

• [Presentation] Diffusion spectrum imaging for traumatic brain injury with neurobehavioral disability (2017)
  • Author(s): Kagari Abiko, Hironobu Iguchi, Satoko Koganemaru, Satoshi Ikeda, Harukazu Tohyama, Katsunori Ikoma
  • Organizer: 第54回日本日本リハビリテーション医学会学術集会