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Toward understanding the neural network abnormalities in cognitive impairment and neuropsychiatric symptoms in epilepsy

Research Project

Project/Area Number 15K01359
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionTohoku University

Principal Investigator

Nishio Yoshiyuki  東北大学, 医学系研究科, 准教授 (90451591)

Co-Investigator(Kenkyū-buntansha) 岩崎 真樹  国立研究開発法人国立精神・神経医療研究センター, 病院, 部長 (00420018)
神 一敬  東北大学, 医学系研究科, 准教授 (20436091)
藤川 真由  東北大学, 大学病院, 助教 (80722371)
Research Collaborator Hiroaki Hosokawa  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords側頭葉てんかん / QOL / 記憶障害 / 顔認知 / 前頭葉てんかん / 作話 / 健康関連QOL / うつ / 認知速度 / 相貌認知
Outline of Final Research Achievements

1. We constructed a health-related QOL model for 150 patients with temporal lobe epilepsy. Higher self-perception of cognitive impairment, lower social function and higher seizure worries were the primary predictors of overall QOL.
2. We investigated face perception abilities in post-surgical patients with left and right anterior lobectomy (ATL) for treatment of drug-resistant temporal lobe epilepsy. Patients with left ATL performed equivalently on the perceptual tasks for front, oblique and noise-masked face images, whereas patients with right ATL performed worse on oblique and noise-masked images compared with on front face images.
3. We published a case series study of confabulation in patients with frontal lobe epilepsy.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (6 results)

All 2017 2016 2015

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Ictal Speech Manifesting as Sleep Talking: A Case Report2017

    • Author(s)
      Suzuki T, Kakisaka Y, Kitazawa Y, Jin K, Sato S, Iwasaki M, Fujikawa M, Nishio Y, Kanno A, Nakasato N.
    • Journal Title

      BRAIN and NERVE

      Volume: 69 Issue: 2 Pages: 167-171

    • DOI

      10.11477/mf.1416200657

    • NAID

      40021096011

    • ISSN
      1344-8129, 1881-6096
    • Year and Date
      2017-02-01
    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fantastic confabulation in right frontal lobe epilepsy2016

    • Author(s)
      Fujikawa M, Nishio Y, Kakisaka Y, Ogawa N, Iwasaki M, Nakasato N.
    • Journal Title

      Epilepsy Behav Case Rep

      Volume: 6 Pages: 55-57

    • DOI

      10.1016/j.ebcr.2016.08.003

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Verbal Dominant Memory Impairment and Low Risk for Post-operative Memory Worsening in Both Left and Right Temporal Lobe Epilepsy Associated with Hippocampal Sclerosis2016

    • Author(s)
      Khalil AF, Iwasaki M, Nishio Y, Jin K, Nakasato N, Tominaga T.
    • Journal Title

      Neurol Med Chir (Tokyo)

      Volume: 56 Pages: 716-723

    • NAID

      130005282106

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Predictors of Quality of Life Among Adults with Temporal Lobe Epilepsy2017

    • Author(s)
      Mayu Fujikawa, Yoshiyuki Nishio, Keiko Endo, Yosuke Kakisaka, Yu Kitazawa, Kazutaka Jin, Nobukazu Nakasato
    • Organizer
      32nd International Epilepsy COngress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 右前部側頭葉切除術後の症例における顔認知能力の検討2016

    • Author(s)
      細川大瑛、西尾慶之、川﨑伊織、平山和美、馬場徹1)、飯塚統、鎌田恭輔、小川博司、 岩崎真樹、中里信和、松田実、森悦朗
    • Organizer
      第40回神経心理学会
    • Place of Presentation
      KKRホテル熊本(熊本市)
    • Year and Date
      2016-10-02
    • Related Report
      2016 Research-status Report
  • [Presentation] 成人側頭葉てんかん患者における Quality of Lifeの決定要因2015

    • Author(s)
      藤川真由
    • Organizer
      第49回日本てんかん学会
    • Place of Presentation
      長崎ブリックホール(長崎)
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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