| Project/Area Number |
15K01363
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | University of Toyama |
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Principal Investigator |
JOHO SHUJI 富山大学, 大学院医学薬学研究部(医学), 講師 (90334721)
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| Research Collaborator |
USHIJIMA Ryuichi
AKABANE Takashi
NAKAGAITO Masaki
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 心不全 / 自律神経 / 交感神経 / ASV療法 / 慢性心不全 / 交感神経活動 / 化学感受性 / 換気応答 / 心臓リハビリテーション |
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| Outline of Final Research Achievements |
This study investigated the effect of adaptive servo-ventilation (ASV) therapy as a part of the cardiac rehabilitation in patients with chronic heart failure, via improving QOL and exercise tolerance. First, we examined the correlation between impaired lung function or ventilatory response and sympathetic overactivation in patients with chronic heart failure, and revealed the mechanism that sympathetic nervous activity was enhanced in patients with impaired lung function. We also determined the relationship between sympathetic nerve activity and prognosis in the patients. In the last year, we focused on nutritional disorders related to the success or failure of cardiac rehabilitation, and examined the effect of ASV therapy on nutritional disorder. We found that ASV therapy improved nutritional status in associated with suppression of sympathetic nerve activity. Thus, ASV therapy might be a useful tool to lead success of cardiac rehabilitation in patients with chronic heart failure.
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