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Study for elucidation of the pathology of sarcopenia and establishment of preventive and therapeutic methods

Research Project

Project/Area Number 15K01373
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionKagoshima University

Principal Investigator

HIGUCHI Itsuro  鹿児島大学, 医歯学域医学系, 教授 (80183573)

Co-Investigator(Kenkyū-buntansha) 榊間 春利  鹿児島大学, 医歯学域医学系, 教授 (10325780)
松田 史代  鹿児島大学, 医歯学域医学系, 助教 (70437953)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsサルコペニア / オートファジー / 老化促進マウス / 封入体筋炎 / 筋病理
Outline of Final Research Achievements

Senescence-Accelerated Mouse Prone 1 (SAMP 1) were raised until 50 weeks of age, divided into exercise and non-exercise group, and were sacrificed 8 weeks later (58 weeks old) and muscle pathological examination was performed. Expression of autophagy related factors such as LC3, p62 was increased in exercise group. There was no significant difference in muscle weight between the two groups. For prevention of sarcopenia, it seems necessary to exercise from younger age. In muscle pathology of the gluteus medius of the elderly woman who had a femoral proximal fracture due to fall, in 2 cases in which type 2 muscle fiber atrophy was markedly observed, upregulation of LC3, rimmed vacuoles, and increased lysosomal activity were observed. It is suggested that sarcopenia and autophagy abnormality are related.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2017 2016

All Presentation (2 results)

  • [Presentation] 高齢者骨折患者の筋量に関する研究2017

    • Author(s)
      中村裕樹, 佐田直哉, 早田善幸, 石田 俊, 末永亮太, 松元 朗, 前島武蔵, 樋口逸郎, 窪田正大
    • Organizer
      第19回 日本骨粗鬆症学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 老化促進マウスを用いた加齢によるサルコペニアのオートファジー関与について2016

    • Author(s)
      園田 真祐美, 樋口 逸郎, 松田 史代
    • Organizer
      第51回日本理学療法学術大会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-05-27
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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