| Project/Area Number |
15K01376
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
Oshiro Takuma 琉球大学, 医学(系)研究科(研究院), 非常勤講師 (00536550)
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| Co-Investigator(Kenkyū-buntansha) |
宮里 実 琉球大学, 医学部, 准教授 (70301398)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 加齢 / 排尿障害 / 膀胱機能 / 尿道機能 / 加齢による排尿の変化 / 膀胱と尿道機能の関係 / 虚血 / 一酸化窒素 / 尿道 |
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| Outline of Final Research Achievements |
In order to confirm the mechanisms of age-associated urinary disfunction, we examined the differences in bladder and urethral activity of young and aging rats.In our study, bladder contractility was not differ among 2 groups. However residual urine volume was significantly increased in aging rats. In the study of urethral function, urethral relaxation was more significantly diminished in the aging rats than in the young. Histological findings that smooth muscle hypertrophy and fibrous tissue hyperplasia were observed in aging rat bladder. Detrusor hyperactivity with impaired contractile function (DHIC) is often occurred with aging. In our study, urethral relaxation was significantly smaller in aging rats. It means that the function of urethral smooth muscle and striated muscle were diminished.
From these results suggest that the decline of bladder and urethral function are one of important factor for cause of residual urine volume increase by aging.
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