The establishment of new system of magnetic stimulation for overactive bladder with age

• Project/Area Number: 15K01377
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: University of the Ryukyus
• Principal Investigator: Miyazato Minoru 琉球大学, 医学(系)研究科(研究院), 准教授 (70301398)
• Co-Investigator(Renkei-kenkyūsha): OSHIRO Takuma 琉球大学, 大学院医学研究科, 非常勤講師 (00536550) ; ASHIKARI Asuka 琉球大学, 大学院医学研究科, 助教 (80768599) ; KIMURA Ryu 琉球大学, 大学院医学研究科, 助教 (50748019)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 磁気刺激 / 過活動膀胱 / 加齢 / Neuromodulation / オピオイド受容体 / neuromodulation / 脊髄

Outline of Final Research Achievements

For the treatment of overactive bladder (OAB), antimuscarinic agents have long been the drug class of choice. However, they can have unpleasant side-effects, such as dry mouth, constipation, headache, blurred vision and tachycardia. In addition, the drugs can also be refractory in some patients with OAB symptoms. Therefore, we aimed to evaluate the efficacy and safety of magnetic stimulation for OAB, as well as stress urinary incontinence, with age. We confirmed restoration of malfunction with OAB by sacral neuromodulation of magnetic stimulation. Thus, magnetic stimulation is useful for urgency incontinence or stress urinary incontinence. In basic research, we confirmed that stimulation of the spinal μ-opioid receptors might be useful for the treatment of stress urinary incontinence in rats.

Research Products

• [Journal Article] Effect of continuous positive airway pressure on nocturnal urine production in patients with obstructive sleep apnea syndrome. (2017)
  • Author(s): Miyazato M, Tohyama K, Touyama M, Nakamura H, Oshiro T, Ueda S, Saito S.
  • Journal Title: Neurourol Urodyn. Volume: 36 Issue: 2 Pages: 376-379
  • DOI: 10.1002/nau.22936
  • Peer Reviewed
• [Journal Article] A questionnaire survey to assess lower urinary tract symptoms in patients with chronic stroke. (2017)
  • Author(s): Miyazato M, Tana T, Higa A, Wakugami K, Tokashiki T, Sakima H, Maehara A, Ashikari A, Oshiro T, Ohya Y, Saito S.
  • Journal Title: Neurourol Urodyn. Volume: 36 Issue: 7 Pages: 1890-1895
  • DOI: 10.1002/nau.23206
  • Peer Reviewed
• [Journal Article] New Frontiers of Basic Science Research in Neurogenic Lower Urinary Tract Dysfunction. (2017)
  • Author(s): Miyazato M, Kadekawa K, Kitta T, Wada N, Shimizu N, de Groat WC, Birder LA, Kanai AJ, Saito S, Yoshimura N.
  • Journal Title: Urol Clin North Am. Volume: 44 Issue: 3 Pages: 491-505
  • DOI: 10.1016/j.ucl.2017.04.014
  • Peer Reviewed
• [Journal Article] Effects of multiple simulated birth traumas on urethral continence function in rats. (2017)
  • Author(s): Yoshikawa S, Sumino Y, Kwon J, Suzuki T, Kitta T, Miyazato M, Yoshimura N.
  • Journal Title: Am J Physiol Renal Physiol. Volume: 313 Issue: 5 Pages: F1089-F1096
  • DOI: 10.1152/ajprenal.00230.2017
• [Journal Article] 特集/高齢化社会で増加する排尿障害 低活動膀胱 (2017)
  • Author(s): 宮里実，斎藤誠一
  • Journal Title: 臨床と研究 Volume: 94 Pages: 21-23
• [Journal Article] 話題 糖尿病と低活動膀胱 (2016)
  • Author(s): 宮里実，斎藤誠一
  • Journal Title: 臨床と研究 Volume: 3 Pages: 626-9
• [Journal Article] 膀胱痛・骨盤痛の遺伝子治療 (2016)
  • Author(s): 宮里実
  • Journal Title: 琉球医学会誌 Volume: 35 Pages: 1-6
  • NAID: 120006422410
• [Journal Article] Effects of switching from alpha-blocker to tadalafil in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (KYU-PRO Study). (2016)
  • Author(s): Miyazato M, Oshiro T, Saito S, Takahashi R, Eto M, Nishii H, Fujimoto N, Sumino Y, Mimata H, Arai K, Kinjo T.
  • Journal Title: Nishinihon J Urol. Volume: 78 Pages: 398-405
  • NAID: 40020911049
  • Peer Reviewed
• [Journal Article] 尿失禁患者を対象とした磁気刺激治療の初期経験 (2016)
  • Author(s): 宮里実,大城琢磨,芦刈明日香
  • Journal Title: 女性健康科科学研究会誌 Volume: 5 Pages: 44-48
• [Journal Article] Influence of 1 year of androgen deprivation therapy on lipid and glucose metabolism and fat accumulation in Japanese patients with prostate cancer. (2016)
  • Author(s): Mitsuzuka K, Kyan A, Sato T, Orikasa K, Miyazato M, Aoki H, Kakoi N, Narita S, Koie T, Namima T, Toyoda S, Fukushi Y, Habuchi T, Ohyama C, Arai Y; Tohoku Evidence-Based Medicine Study Group; Michinoku Urological Cancer Study Group.
  • Journal Title: Prostate Cancer Prostatic Dis. Volume: 19 Issue: 1 Pages: 57-62
  • DOI: 10.1038/pcan.2015.50
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effects of Duloxetine, a Norepinephrine and Serotonin Reuptake Inhibitor, on the Urethral Continence Reflex and Bladder Activity in Rats with Cerebral Infarction. (2015)
  • Author(s): Miyazato M, Kitta T, Kaiho Y, Oshiro T, Saito S, Chancellor MB, de Groat WC, Yoshimura N.
  • Journal Title: J Urol Volume: 194 Issue: 3 Pages: 842-7
  • DOI: 10.1016/j.juro.2015.03.091
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Awareness of folic acid use increases its consumption, and reduces the risk of spina bifida. (2015)
  • Author(s): Kondo A, Morota N, Date H, Yoshifuji K, Morishima T, Miyazato M, Shirane R, Sakai H, Pooh KH, Watanabe T.
  • Journal Title: Br J Nutr. Volume: 114 Issue: 1 Pages: 84-90
  • DOI: 10.1017/s0007114515001439
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 閉塞型睡眠時無呼吸症候群患者を対象とした持続陽圧呼吸療法の夜間頻尿改善効果に関する観察研究. (2015)
  • Author(s): 宮里実, 芦刈明日香,大城琢磨,斎藤誠一．
  • Journal Title: 日本老年泌尿器科学会雑誌． Volume: 28 Pages: 41-41
• [Journal Article] 80歳以上の高齢者における泌尿器科手術の周術期合併症. (2015)
  • Author(s): 宮里実, 與那嶺智子,泉惠一朗,宮城亮太,芦刈明日香,仲西昌太郎,木村隆,松村英理,大城琢磨,呉屋真人,斎藤誠一．
  • Journal Title: 西日泌尿器． Volume: 77 Pages: 446-50
  • NAID: 40020685524
• [Presentation] Effect of the Continuous Positive Airway Pressure on the Nocturnal Urine Volume in Patients with Obstructive Sleep Apnea Syndrome． (2017)
  • Author(s): Minoru Miyazato
  • Organizer: 第105回日本泌尿器科学会総会．
• [Presentation] ラットくしゃみ誘発尿禁制反射における脊髄セロトニン機構の役割． (2017)
  • Author(s): 宮里実．
  • Organizer: 第94回生理学会大会．
• [Presentation] A questionnaire survey for urological disturbances using core lower urinary tract symptom score in patients with chronic stroke (2016)
  • Author(s): Miyazato M, Ashikari A, Oshiro T, Saito S
  • Organizer: 46th annual meeting of the International Continence Society
  • Place of Presentation: Tokyo
  • Year and Date: 2016-09-16
• [Presentation] 脳卒中患者の中における排尿障害の実態調査． (2015)
  • Author(s): 379．宮里実、大城琢磨、芦刈明日香、田名毅、湧上聖、渡嘉敷崇、崎間洋邦、前原愛和、斎藤誠一．
  • Organizer: 第120回沖縄県医師会医学会総会．
  • Place of Presentation: 沖縄県医師会館（沖縄、南風原）
  • Year and Date: 2015-12-13
• [Presentation] 腎盂壁Ｕ字フラップを利用した腹腔鏡下左腎盂形成術の一例． (2015)
  • Author(s): 宮里実、與那嶺智子、泉惠一朗、宮城亮太、仲西昌太郎、芦刈明日香、木村隆、呉屋真人、斎藤誠一．
  • Organizer: 第29回日本泌尿器内視鏡学会総会
  • Place of Presentation: 京王プラザホテル（東京）
  • Year and Date: 2015-11-20
• [Presentation] TRAMADOL ENHANCES URETHRAL CONTINENCE REFLEX DURING SNEEZING THROUGH μ-OPIOID RECEPTORS IN THE SPINAL CORD IN RATS. (2015)
  • Author(s): Ashikari A, Miyazato M, Oshiro T, Saito S.
  • Organizer: 45th annual meeting of the International Continence Society
  • Place of Presentation: モントリオール（カナダ）
  • Year and Date: 2015-10-09
  • Int'l Joint Research
• [Presentation] Effect of the Continuous Positive Airway Pressure on the Nocturnal Urine Volume in Patients with Obstructive Sleep Apnea Syndrome. (2015)
  • Author(s): Miyazato M, Oshiro T, Ashikari A, Saito S.
  • Organizer: 45th annual meeting of the International Continence Society
  • Place of Presentation: モントリオール（カナダ）
  • Year and Date: 2015-10-07
  • Int'l Joint Research
• [Presentation] α遮断薬効果不十分の前立腺肥大症患者に対するタダラフィルへの切り替え効果（KYU-PRO STUDY）． (2015)
  • Author(s): 宮里実，大城琢磨，斎藤誠一，高橋良輔，西井久枝，藤本直浩，住野泰弘，三股浩光．
  • Organizer: 第22回日本排尿機能学会
  • Place of Presentation: 京王プラザホテル札幌（北海道、札幌）
  • Year and Date: 2015-09-11
• [Presentation] 閉塞型睡眠時無呼吸症候群患者を対象とした持続陽圧呼吸療法の夜間頻尿改善効果に関する観察研究． (2015)
  • Author(s): 宮里実，芦刈明日香，大城琢磨，斎藤誠一．
  • Organizer: 第28回日本老年泌尿器科学会．
  • Place of Presentation: アクトシティ浜松コングレスセンター（静岡、浜松）
  • Year and Date: 2015-05-09
• [Presentation] 琉球大学における密封小線源療法初期100例の検討． (2015)
  • Author(s): 宮里実、有賀拓郎、町田典子、大城琢磨、仲西昌太郎、戸板孝文、粕谷吾朗、椎名秀樹、宮城亮太、木村隆、玉城光由、松村英理、呉屋真人、大城吉則、村山貞之、斎藤誠一．
  • Organizer: 第103回日本泌尿器科学会総会．
  • Place of Presentation: 石川県立音楽堂（石川、金沢）
  • Year and Date: 2015-04-19
• [Patent(Industrial Property Rights)] 脊髄オピオイドμ受容体を介した新規腹圧性尿失禁薬剤 (2017)
  • Inventor(s): 宮里実、芦刈明日香
  • Industrial Property Rights Holder: 宮里実、芦刈明日香
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017