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The development of beneficial exercise under noninvasive positive pressure ventilation for physical activity and health

Research Project

Project/Area Number 15K01382
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionYokohama City University

Principal Investigator

NAKAMURA Takeshi  横浜市立大学, 医学研究科, 教授 (80299635)

Co-Investigator(Kenkyū-buntansha) 西村 行秀  和歌山県立医科大学, 医学部, 講師 (20464117)
坂野 元彦  和歌山県立医科大学, 医学部, その他 (70512127)
Research Collaborator MORIKI Takashi  
KAWAZU Takamitsu  
KINOSHITA Tokio  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords非侵襲的陽圧換気 / 体力 / BDNF / 有酸素運動 / 最大酸素摂取量 / 心肺能力 / 運動負荷試験 / 呼気ガス分析 / IL-6 / トレーニング
Outline of Final Research Achievements

The subjects of healthy young men exercised on a cycle ergometer at 60% of pretraining maximal oxygen uptake for 30 minutes daily for 5 consecutive days with or without noninvasive positive pressure ventilation (NPPV, 12 cmH2O). The 5-day exercise protocol was repeated after a 3-week washout period with or without NPPV. Maximal oxygen uptake and brain-derived neurotrophic factor (BDNF) were measured before and after the 5-day training with or without NPPV.
Maximal oxygen uptake significantly increased after the 5-day training with and without NPPV, but the magnitude of increase in maximal oxygen uptake after training under NPPV was significantly higher than after training without NPPV. Serum BDNF significantly increased after the 5-day training with NPPV, but not without NPPV.
Aerobic training under NPPV has add-on effects on maximal oxygen uptake and serum BDNF, and exercise-related health benefits in healthy young men.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report

Research Products

(3 results)

All 2017 2016 2015

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Noninvasive positive pressure ventilation enhances the effects of aerobic training on cardiopulmonary function2017

    • Author(s)
      Moriki Takashi、Nakamura Takeshi、Kamijo Yoshi-ichiro、Nishimura Yukihide、Banno Motohiko、Kinoshita Tokio、Uenishi Hiroyasu、Tajima Fumihiro
    • Journal Title

      PLOS ONE

      Volume: 12

    • DOI

      10.1371/journal.pone.0178003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aerobic Exercise Combined With Noninvasive Positive Pressure Ventilation Increases Serum Brain-Derived Neurotrophic Factor in Healthy Males.2016

    • Author(s)
      Takamitsu Kawazu, Takeshi Nakamura, Takashi Moriki, Yoshi-ichiro Kamijo, Yukihide Nishimura, Tokio Kinoshita, Fumihiro Tajima
    • Journal Title

      PM&R

      Volume: 8(12) Pages: 1136-1141

    • DOI

      10.1016/j.pmrj.2016.05.004

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 非侵襲的陽圧換気下の有酸素トレーニングは体力増強効果を向上させる2015

    • Author(s)
      中村 健
    • Organizer
      第65回日本体質医学会総会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2015-07-04
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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