| Project/Area Number |
15K01406
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kumamoto Health Science University |
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Principal Investigator |
iiyama junichi 熊本保健科学大学, 保健科学部, 教授 (00398299)
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| Co-Investigator(Kenkyū-buntansha) |
岩下 佳弘 熊本保健科学大学, 保健科学部, 講師 (70623510)
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| Co-Investigator(Renkei-kenkyūsha) |
KUWABARA Takashige 熊本大学, 医学部, 助教 (00393356)
MUKOUYAMA Masashi 熊本大学, 医学部, 教授 (40270558)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 慢性腎臓病 / 温熱療法 / リハビリテーション / 反復効果 / 機能維持 / 尿細管障害軽減 / アポトーシス抑制 / 酸化ストレス抑制 / 全身温熱の反復 / 非薬物療法 / 腎不全 / 内部障害のリハビリテーション / 慢性腎臓病モデルマウス / 低温サウナ / 近位尿細管障害 / アポトーシス減少 / HSP27 |
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| Outline of Final Research Achievements |
Chronic kidney disease model mice were prepared due to kidney volume reduction and interposed 4 weeks at a frequency of 5 days / week with a protocol that raised deep body temperature by about 1 - 1.5 centigrade and maintained for about 30 minutes. As a result, it was confirmed that significant protective effects of mild thermal exposure on serum creatinine and urine albumin level. As a mechanism, these were suggested that improvement of antioxidant capacity via activation of the p38 MAPK-Akt pathway and reduction of apoptosis by the expression amplification of Heat Shock Protein (HSP) 27(Am J Phys Renal phys. 2016, This article was selected APS certification and editor's picks of AJP-Renal Physiology.).
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