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The study of mechanism of referred pain in patients with hip joint disease and Significance Significance significance of clinical evaluation

Research Project

Project/Area Number 15K01418
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionNagasaki University

Principal Investigator

SAKAMOTO Junya  長崎大学, 医歯薬学総合研究科(保健学科), 准教授 (20584080)

Co-Investigator(Kenkyū-buntansha) 中野 治郎  長崎大学, 医歯薬学総合研究科(保健学科), 准教授 (20380834)
弦本 敏行  長崎大学, 医歯薬学総合研究科(医学系), 教授 (60304937)
真鍋 義孝  長崎大学, 医歯薬学総合研究科(歯学系), 教授 (80131887)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords関連痛 / 二分軸索感覚ニューロン / カルシトニン遺伝子関連ペプチド / 神経性炎症 / 変形性股関節症 / 肉眼解剖学 / 関節枝 / 二分軸索ニューロン
Outline of Final Research Achievements

We hypothesized that dichotomizing axons projecting to both the hip joint and the knee joint involve in the development of referred pain in patients with hip disease. Therefore, we examined that hypothesis with gross anatomical method and animal study. As results, gross anatomical findings and neuroanatomical findings in animal study suggested the existence of dichotomizing peripheral sensory fibers innervating hip and knee joint. In addition, it revealed that calcitonin gene related peptide involved in the development of referred pain in knee joint derived from hip osteoarthritis in rat hip osteoarthritis model. We believed that dichotomizing peripheral sensory fibers may relate to the referral pain confirmed in the anterior knee joint of patients with hip disease.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (22 results)

All 2018 2017 2016 2015 Other

All Journal Article (9 results) (of which Peer Reviewed: 6 results,  Open Access: 2 results) Presentation (12 results) (of which Int'l Joint Research: 4 results) Remarks (1 results)

  • [Journal Article] Anatomical study of the articular branches innervated the hip and knee joint with reference to mechanism of referral pain in hip joint disease patients.2018

    • Author(s)
      Sakamoto J, Manabe Y, Oyamada J, Kataoka H, Nakano J, Saiki K, Tsurumoto T, Okita M
    • Journal Title

      Clin Anat

      Volume: 印刷中 Issue: 5 Pages: 705-709

    • DOI

      10.1002/ca.23077

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between extensibility and collagen expression in immobilized rat skeletal muscle.2018

    • Author(s)
      Honda Y, Tanaka M, Tanaka N, Sasabe R, Goto K, Kataoka H, Sakamoto J, Nakano J, Okita M
    • Journal Title

      Muscle Nerve.

      Volume: 57 Pages: 672-678

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The influence of aging on the effectiveness of heat stress in preventing disuse muscle atrophy.2017

    • Author(s)
      Kataoka H, Nakano J, Kondo Y, Honda Y, Sakamoto J, Okita M
    • Journal Title

      Physiol Int

      Volume: 104 Pages: 316-328

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 不活動に伴う痛みの発生メカニズムとその治療戦略に関する検討-ラットの実験モデルに対する振動刺激の効果-2017

    • Author(s)
      濱上陽平,中野治郞,坂本淳哉,沖田 実
    • Journal Title

      日本基礎理学療法学雑誌

      Volume: 20 Pages: 8-15

    • NAID

      130007490555

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 痛みの末梢機構の再考2017

    • Author(s)
      濱上陽平,中野治郞,坂本淳哉,沖田 実
    • Journal Title

      Pain Rehabilitation

      Volume: 7 Pages: 8-15

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Effect of continuous passive motion initiated after the onset of arthritis on inflammation and secondary hyperalgesia in rats.2016

    • Author(s)
      Nakabayashi K, Sakamoto J, Kataoka H, Kondo Y, Hamaue Y, Honda Y, Nakano J, Okita M
    • Journal Title

      Physiol Res.

      Volume: 65 Pages: 683-691

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of early physical activity time with pain, activities of daily living, and progression of vertebral body collapse in patients with vertebral compression fractures: an observational study at single institution.2016

    • Author(s)
      Kataoka H, Ikemoto T, Yoshimura A, Shibuya M, Goto K, Yamashita J, Morita K, Sakamoto J, Nakano J, Okita M
    • Journal Title

      Eur J Phys Rehabil Med.

      Volume: in press

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] アジュバント誘発炎症モデルラットの皮膚アロディニアに対するリモイスRコートの効果2016

    • Author(s)
      中野治郞,川内春奈,坂本淳哉,沼田 悟,岩嵜徹治,沖田 実
    • Journal Title

      日本運動器疼痛学会誌

      Volume: 8 Pages: 12-19

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 疼痛に対する物理療法の基礎的背景とエビデンス2016

    • Author(s)
      中野治郞,坂本淳哉,片岡英樹,沖田 実
    • Journal Title

      理学療法

      Volume: 33 Pages: 416-423

    • Related Report
      2016 Research-status Report
  • [Presentation] ラットの股関節と膝関節を支配する二分軸索感覚ニューロンの神経解剖学的検索2018

    • Author(s)
      坂本淳哉、本田祐一郎、片岡英樹、中野治郎、沖田 実
    • Organizer
      第40回日本疼痛学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 竹下いづみ、坂本淳哉、濱平真由、佐々木遼、石川空美子、片岡英樹、中野治郎、沖田 実2018

    • Author(s)
      股関節疾患における関連痛の発生メカニズムの検討-変形性股関節症モデルラットを用いた実験的研究-
    • Organizer
      第40回日本疼痛学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Low-intensity muscle contraction during acute phase of arthritis reduces inflammation symptoms and secondary hyperalgesia through biological changes in the joint and spinal cord of rats.2017

    • Author(s)
      J. Sakamoto, Y.Kajiwara, K.Ishikawa, R.Sasaki , Y.Honda ,H.kataoka ,J.Nakno, M. Okita
    • Organizer
      EFIC2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cryotherapy reduces inflammatory symptoms and secondary hyperalgesia via decreasing accumulation of macrophage and central sensitization.2017

    • Author(s)
      R. Sasaki, J. Sakamoto, Y. Kondo, Y.Hamaue , R.Sasabe, Y.Honda, J. Nakano, M. Okita
    • Organizer
      EFIC2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of low-intensity muscle contraction and sensory input during the early stages of arthritis on joint swelling and pain.2016

    • Author(s)
      J. Sakamoto, K. Teranaka, Y. Kondo, Y. Hamaue, Y. Honda, H. Kataoka, J. Nakano, M. Okita
    • Organizer
      16th World Congress on Pain
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] The role of NGF in immobilization-induced hyperalgesia in rats.2016

    • Author(s)
      Y. Hamaue, J. Nakano, Y.Sekino, J. Sakamoto, M. Okita
    • Organizer
      16th World Congress on Pain
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 不動に伴う痛覚過敏の発生メカニズムとその治療戦略に関する検討ーラット足関節不動化モデルに対する振動刺激の効果ー.2016

    • Author(s)
      濱上陽平,中野治郞,坂本淳哉,沖田 実
    • Organizer
      第51回日本理学療法学術大会
    • Place of Presentation
      札幌コンベンションセンター(北海道、札幌市)
    • Year and Date
      2016-05-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 股関節疾患患者にみられる関連痛の発生機序解明にむけた関節枝の分布状況に関する肉眼解剖学的検討2016

    • Author(s)
      坂本淳哉,真鍋義孝,弦本敏行,本田祐一郎,片岡英樹,中野治郎,沖田 実
    • Organizer
      第51回日本理学療法学術大会
    • Place of Presentation
      札幌コンベンションセンター(北海道、札幌市)
    • Year and Date
      2016-05-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 持続的他動運動がラット膝関節炎発症後早期の炎症や痛みにおよぼす影響.2016

    • Author(s)
      近藤康隆,坂本淳哉,寺中 香,片岡英樹,濵上陽平,佐々部陵,佐々木遼,中野治郎,沖田  実
    • Organizer
      第51回日本理学療法学術大会
    • Place of Presentation
      札幌コンベンションセンター(北海道、札幌市)
    • Year and Date
      2016-05-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 股関節疾患患者にみられる関連痛の発生機序解明にむけた関節枝の分布状況に関する肉眼解剖学的検討2016

    • Author(s)
      坂本淳哉,真鍋義孝,弦本敏行,本田祐一郎,片岡英樹,中野治郎,沖田 実
    • Organizer
      第51回日本理学療法学術大会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-05-27
    • Related Report
      2015 Research-status Report
  • [Presentation] 股関節疾患患者の関連痛の発生機序解明にむけた関節枝の分布状況に関する肉眼解剖学的検討2015

    • Author(s)
      坂本淳哉,真鍋義孝,弦本敏行,中野治郎,沖田 実
    • Organizer
      第8回日本運動器疼痛学会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-12-12
    • Related Report
      2015 Research-status Report
  • [Presentation] he relation between referral pain and the nerve distribution in hip and knee joints.2015

    • Author(s)
      Sakamoto J, Nakano J, Kataoka H, Manabe Y, Tsurumoto T, Okita M
    • Organizer
      The 9th Congress of the European Pain Federation
    • Place of Presentation
      ウィーン(オーストリア)
    • Year and Date
      2015-09-02
    • Related Report
      2015 Research-status Report
  • [Remarks] 長崎大学大学院医歯薬学総合研究科運動障害リハビリテーション学研究室

    • URL

      http://www2.am.nagasaki-u.ac.jp/pt/basic_pt/article.html

    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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