| Project/Area Number |
15K01434
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Rehabilitation science/Welfare engineering
|
|---|
| Research Institution | Teikyo University of Science & Technology |
|---|
Principal Investigator |
HIROSE NOBORU 帝京科学大学, 医療科学部, 准教授 (60460391)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
斉藤 史明 帝京大学, 医学部, 准教授 (40286993)
萩原 宏毅 帝京科学大学, 医療科学部, 教授 (80276732)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 筋萎縮 / 酸化ストレス / 再荷重 / 微細筋損傷 / 抗酸化力 / 炎症性サイトカイン / サイトカイン / 運動療法 |
|---|
| Outline of Final Research Achievements |
While several studies have reported the relationship between these markers and exercise, little is known about the dynamic nature of these markers during muscle atrophy and reloading. Therefore, we examined changes in oxidative stress and microscopic damage to the muscle during muscle atrophy and reloading. Muscle atrophy was induced in mice by casting the limb for 2 weeks. Mice were then subjected to reloading for 2 weeks. There was infiltration of inflammatory cells immediately after reloading and possibly microscopic damage to the muscle occurred. The degree of oxidative stress was within the normal range throughout the experimental period. The antioxidant potential decreased to the clinical borderline level 2 weeks after immobilization, further decreased after 1 day of reloading, and then recovered to within the normal range. Performing d-ROMs and BAP tests may contribute to the understanding to atrophic process of skeletal muscle in clinical practice of rehabilitation.
|
