The execise intensities causing muscle injury inhibits recovery from muscle atrophy

• Project/Area Number: 15K01436
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Nagoya Gakuin University
• Principal Investigator: Itoh Yuta 名古屋学院大学, リハビリテーション学部, 講師 (30454383)
• Co-Investigator(Renkei-kenkyūsha): HAYAKAWA KIMIHIDE 名古屋大学, 医学系研究科, 特任講師 (60467280)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 筋萎縮 / 筋損傷 / 炎症反応 / 運動負荷強度

Outline of Final Research Achievements

To clarify the relationship between muscle injury and the facilitating recovery of atrophied muscles, mice recovering from atrophied muscles underwent repeated isometric training with varying joint torques using electrical stimulation. As a result, the functional and histological effect from the muscle atrophy were worked on by applying exercise equal to or greater than a definite intensity level. However, the application of intense exercise caused vicious muscle injury inhibited recovery of muscle strength and myofiber size. These data indicate that resistance training without muscle damage facilitates efficient recovery from atrophy.

Research Products

• [Journal Article] Recovery from Muscle Atrophy is Facilitated by Stand-up Exercise Training without Muscle Inflammation Responses (2017)
  • Author(s): 伊東佑太、小倉崚、水谷健悟、磯野真
  • Journal Title: 名古屋学院大学論集 医学・健康科学・スポーツ科学篇 Volume: 5 Issue: 2 Pages: 1-10
  • DOI: 10.15012/00000923
  • NAID: 120006029700
  • ISSN: 2187-5162
  • URL: https://ngu.repo.nii.ac.jp/records/934
  • Year and Date: 2017-03-31
  • Peer Reviewed / Open Access
• [Journal Article] Training at non-damaging intensities facilitates recovery from muscle atrophy. (2017)
  • Author(s): Itoh Y, Murakami T, Mori T, Agata N, Kimura N, Inoue-Miyazu M, Hayakawa K, Hirano T, Sokabe M, Kawakami K
  • Journal Title: Muscle and Nerve Volume: 55(2) Issue: 2 Pages: 243-253
  • DOI: 10.1002/mus.25218
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 老化性筋萎縮に対する定量的な伸張刺激の効果 (2017)
  • Author(s): 西尾紗央里、佐々木志織、鈴木純也、伊東佑太
  • Organizer: 第52回日本理学療法学術大会
• [Presentation] 不活動初期の腓腹筋におけるマクロファージとNGFの発現 (2017)
  • Author(s): 大来田智也、須藤佑太、伊東佑太、肥田朋子
  • Organizer: コ・メディカル形態機能学会 第16回学術集会
• [Presentation] 運動刺激下の既存筋線維への筋衛星細胞の取り込み (2017)
  • Author(s): 伊東佑太
  • Organizer: 第2回 基礎理学療法学 夏の学校
  • Invited
• [Presentation] マウス足関節底屈筋群の遠心性収縮による筋損傷モデルの開発 (2016)
  • Author(s): 伊東佑太、鈴木惇也、縣信秀、木村菜穂子、平野孝行、河上敬介
  • Organizer: 第51回日本理学療法学術大会（日本理学療法士協会）
  • Place of Presentation: 札幌コンベンションセンター（北海道・札幌）
  • Year and Date: 2016-05-27
• [Presentation] The effective intensity of exercise load for facilitating recovery from muscle atrophy in mice (2015)
  • Author(s): Y Itoh, N Agata, N Kimura, M Inoue-Miyazu, T Hirano, K Hayakawa, T Murakami, K Kawakami
  • Organizer: World Confederation for Physical Therapy Congress 2015 (WCPT)
  • Place of Presentation: Suntec (Singapore)
  • Year and Date: 2015-05-02
• [Remarks] 名古屋学院大学 研究等業績一覧
  • URL: http://www.ngu-kenkyu-db.jp/