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Role of the spinocerebellar loop for the execution and learning of the motor skill

Research Project

Project/Area Number 15K01498
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Developmental mechanisms and the body works
Research InstitutionThe University of Tokyo

Principal Investigator

YANAGIHARA Dai  東京大学, 大学院総合文化研究科, 准教授 (90252725)

Co-Investigator(Kenkyū-buntansha) 舩戸 徹郎  電気通信大学, 大学院情報理工学研究科, 准教授 (40512869)
青井 伸也  京都大学, 工学研究科, 講師 (60432366)
Research Collaborator FUJIKI Soichiro  東京大学, 大学院総合文化研究科, 助教
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords歩行 / 小脳 / 脊髄 / 適応 / 筋骨格モデル / 神経制御モデル / 動力学シミュレーション / 位相調節 / 感覚情報 / 股関節 / 神経筋骨格モデル / 運動スキル / ラット / シナジー / 脳梗塞
Outline of Final Research Achievements

It is generally accepted that the nervous system achieve adaptability of locomotion in diverse environments by controlling the redundant musculoskeletal systems. An available tool that has been used to investigate the locomotor adaptation in humans and animals is the split-belt treadmill. When the belt speed in the split-belt treadmill changes to asymmetric condition, animals as well as humans show immediate and gradual adaptation in locomotion parameters. Previous studies have shown that the cerebellum has a critical involvement for the gradual adaptation. In this study, we have the neurophysiological experiments in rodents and the dynamic simulation by the constructed neuromusculoskeletal model of the rat. When we incorporated a cerebellar model to change the temporal locomotion parameters based on the error information of foot timings, the gradual adaptation was observed. These findings will improve the understanding of the spinocerebellar loop for the adaptability of locomotion.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (24 results)

All 2018 2017 2016 2015

All Journal Article (6 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (18 results) (of which Int'l Joint Research: 7 results)

  • [Journal Article] Progressive impairment of cerebellar mGluR signalling and its therapeutic potential for cerebellar ataxia in spinocerebellar ataxia type 1 model mice.2017

    • Author(s)
      Shuvaev AN, Hosoi N, Sato Y, Yanagihara D, Hirai H.
    • Journal Title

      The Journal of Physiology

      Volume: 595(1) Issue: 1 Pages: 141-164

    • DOI

      10.1113/jp272950

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Exercise-induced expression of monocarboxylate transporter 2 in the cerebellum and its contribution to motor performance.2016

    • Author(s)
      Daisuke Hoshino, Susumu Setogawa, Yu Kitaoka, Hiroyuki Masuda, Yuki Tamura, Hideo Hatta, Dai Yanagihara.
    • Journal Title

      Neurosci Lett

      Volume: 633 Pages: 1-6

    • DOI

      10.1016/j.neulet.2016.09.012

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Involvement of GluD2 in fear-conditioned bradycardia in mice.2016

    • Author(s)
      Kotajima-Murakami, H., Narumi, S., Yuzaki, M., Yanagihara, D.
    • Journal Title

      PLoS ONE

      Volume: 11 Issue: 11 Pages: e0166144-e0166144

    • DOI

      10.1371/journal.pone.0166144

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] ネコの歩行運動と四脚歩行ロボット2015

    • Author(s)
      柳原 大, 藤木 聡一朗
    • Journal Title

      体育の科学

      Volume: 65 Pages: 467-471

    • Related Report
      2015 Research-status Report
  • [Journal Article] げっ歯類(マウス・ラット)の障害物回避歩行2015

    • Author(s)
      佐藤 和, 瀬戸川 将, 青木 祥, 柳原 大
    • Journal Title

      体育の科学

      Volume: 65 Pages: 461-466

    • Related Report
      2015 Research-status Report
  • [Journal Article] 姿勢と歩行の制御における新たな小脳機能2015

    • Author(s)
      柳原 大
    • Journal Title

      Clinical Neuroscience

      Volume: 33 Pages: 763-766

    • Related Report
      2015 Research-status Report
  • [Presentation] 歩行中の位相リセットのシンプルな神経筋骨格モデルに基づく数理解析2018

    • Author(s)
      藤木聡一朗、青井伸也、柳原 大、土屋和雄
    • Organizer
      第30回自律分散システムシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Photothrombosis法を用いた小脳梗塞が歩行機能に及ぼす影響2018

    • Author(s)
      淺香明子、柳原毬夏、藤木聡一朗、李佐知子、彼末一之、石川欽也、柳原 大
    • Organizer
      第16回姿勢と歩行研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ラットの左右分離型トレッドミル歩行計測に基づく神経制御モデルの構築2018

    • Author(s)
      藤木聡一朗、青井伸也、舩戸徹郎、土屋和雄、柳原 大
    • Organizer
      第16回姿勢と歩行研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ラットの神経筋骨格モデルを用いた歩容生成とエネルギー効率の考察2018

    • Author(s)
      戸枝美咲、青井伸也、藤木聡一朗、舩戸徹郎、土屋和雄、柳原 大
    • Organizer
      第16回姿勢と歩行研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ラット後肢左右分離型トレッドミル歩行の運動学シナジー解析2017

    • Author(s)
      藤木聡一朗, 佐藤陽太, 舩戸徹郎, 青井伸也, 土屋和雄, 柳原 大
    • Organizer
      第29回自律分散システムシンポジウム
    • Place of Presentation
      調布クレストンホテル(東京都調布市)
    • Year and Date
      2017-01-30
    • Related Report
      2016 Research-status Report
  • [Presentation] 運動予測の最適化と運動主体感について2017

    • Author(s)
      松本知晃, 柳原 大
    • Organizer
      第29回自律分散システムシンポジウム
    • Place of Presentation
      調布クレストンホテル(東京都調布市)
    • Year and Date
      2017-01-30
    • Related Report
      2016 Research-status Report
  • [Presentation] Lesions to the olivo-cerebellar pathway disturbed a toe trajectory during stepping over an obstacle in rat2016

    • Author(s)
      Sato, Y., Aoki, S., Yanagihara, D.
    • Organizer
      The Society for Neuroscience Annual Meeting 2016
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Synergy analysis of rat walling for elucidating the dysfunction due to neurological disorder2016

    • Author(s)
      Suzuki, R., Funato, T., Yanagihara, D., Fujiki, S., Sato, Y., Aoi, S., Tsuchiya, K.
    • Organizer
      The Society for Neuroscience Annual Meeting 2016
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Simulation of adaptive interlimb coordination during locomotion on split-belt treadmill using a rat hindlimb neuromusculoskeletal model2016

    • Author(s)
      Fujiki, S., Aoi, S., Funato, T., Tsuchiya, K., Yanagihara, D.
    • Organizer
      The Society for Neuroscience Annual Meeting 2016
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Intersegmental coordination of bipedally standing rat2016

    • Author(s)
      Sato, Y., Funato, T., Yanagihara, D., Sato, Y., Fujiki, S., Aoi, S., Tsuchiya, K.
    • Organizer
      The Society for Neuroscience Annual Meeting 2016
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ラットの左右分離型トレッドミル歩行の計測とシミュレーション2016

    • Author(s)
      藤木聡一朗, 青井伸也, 舩戸徹郎, 柳原 大, 土屋和雄
    • Organizer
      第31回生体・生理工学シンポジウム
    • Place of Presentation
      大阪国際交流センター(大阪府大阪市)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
  • [Presentation] ラットの神経筋骨格モデルを用いた感覚フィードバックの障害による歩行機能障害とその回復に関する検討2016

    • Author(s)
      戸枝美咲, 青井伸也, 藤木聡一朗, 舩戸徹郎, 土屋和雄, 柳原 大
    • Organizer
      第71回日本体力医学会大会
    • Place of Presentation
      いわて県民情報交流センター(岩手県盛岡市)
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
  • [Presentation] The optimization of Sensory Prediction and Sense of Agency2016

    • Author(s)
      Matsumoto, T., Yanagihara, D., Tanno, Y.
    • Organizer
      31st International Congress of Psychology
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ラットの神経筋骨格モデルに基づく左右分離型トレッドミル歩行における長期適応の生成2016

    • Author(s)
      藤木聡一朗, 青井伸也, 舩戸徹郎, 柳原 大, 土屋和雄
    • Organizer
      第28回自律分散システムシンポジウム
    • Place of Presentation
      広島大学東広島キャンパス学士会館(広島県 東広島市)
    • Year and Date
      2016-01-21
    • Related Report
      2015 Research-status Report
  • [Presentation] 筋シナジー制御を用いた四肢神経筋骨格モデルの歩容生成とエネルギー効率の考察2015

    • Author(s)
      戸枝美咲, 青井伸也, 舩戸徹郎, 土屋和雄, 柳原 大
    • Organizer
      第70回日本体力医学会大会
    • Place of Presentation
      和歌山県民文化会館(和歌山県 和歌山市)
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 腹側被蓋野破壊が歩行時の障害物回避動作へ及ぼす影響2015

    • Author(s)
      瀬戸川 将, 柳原 大
    • Organizer
      第70回日本体力医学会大会
    • Place of Presentation
      和歌山県民文化会館(和歌山県 和歌山市)
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Investigation of adaptive split-belt treadmill walking by the hindlimbs of rats.2015

    • Author(s)
      Fujiki, S., Aoi, S., Yanagihara, D., Funato, T., Sato, Y., Senda, K., Tsuchiya, K.
    • Organizer
      The 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Milano Conference Center (Milan, Italy)
    • Year and Date
      2015-08-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Investigating adaptation in hindlimb split-belt treadmill walking by rats using kinematic measurement and a neuromusculoskeletal model.2015

    • Author(s)
      Aoi, S., Fujiki, S., Yanagihara, D., Funato, T., Sato, Y., Tomita, N., Ogihara, N., Senda, K., Tsuchiya, K.
    • Organizer
      2015 ISPGR World Congress
    • Place of Presentation
      Melia Sevilla Hotel (Seville, Spain)
    • Year and Date
      2015-06-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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