The effect of motor traning for cognitive function

• Project/Area Number: 15K01501
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Developmental mechanisms and the body works
• Research Institution: Yamaguchi University
• Principal Investigator: KIDA Hiroyuki 山口大学, 大学院医学系研究科, 講師 (70432739)
• Co-Investigator(Renkei-kenkyūsha): MITSUSHIMA Dai 山口大学, 大学院医学系研究科, 教授 (70264603) ; YAMAMOTO Yui 東北医科薬科大学, 医学部, 助教 (80635087)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: AMPA受容体 / 運動学習 / 環境エンリッチメント / 認知機能 / 記憶 / BDNF / 運動

Outline of Final Research Achievements

To investigate the effect of voluntary movement in developmental period for cognitive function, we kept 3 week age mice in the environmental enrichment (EE) for 2 weeks. We examined AMPA receptor expression and Brain drive neurotrophic factor (BDNF) after in cingulate cortex after voluntary movement. The EE grope showed significantly increase of anti-anxiety behavior and inhibitory avoidance (IA) score, and positive correlation between IA score and the amount of movement. In addition, although AMPA receptor expression did not change, BDNF expression significantly increased in the EE group. These results suggest the trophic effect of voluntary movement in developmental period.

Research Products

• [Journal Article] Mechanisms of motor learning mediated by synaptic plasticity in rat primary motor cortex. (2017)
  • Author(s): Kida Hiroyuki、Mitsushima Dai.
  • Journal Title: Neurosci Res Volume: 128 Pages: 14-18
  • DOI: 10.1016/j.neures.2017.09.008
  • Peer Reviewed / Open Access
• [Journal Article] Differential Temperature Sensitivity of Synaptic and Firing Processes in a Neural Mass Model of Epileptic Discharges Explains Heterogeneous Response of Experimental Epilepsy to Focal Brain Cooling (2017)
  • Author(s): Jaymar Soriano, Takatomi Kubo, Takao Inoue, Hiroyuki Kida,Toshitaka Yamakawa, Michiyasu Suzuki, Kazushi Ikeda
  • Journal Title: PLoS Computational Biology Volume: 13 Issue: 10 Pages: e1005736-e1005736
  • DOI: 10.1371/journal.pcbi.1005736
  • NAID: 120006354240
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity (2017)
  • Author(s): Kida Hiroyuki、Sakimoto Yuya、Mitsushima Dai
  • Journal Title: Journal of Visualized Experiments Volume: 129 Issue: 129 Pages: 1-11
  • DOI: 10.3791/55876
  • Peer Reviewed / Open Access
• [Journal Article] Epidural Focal Brain Cooling Abolishes Neocortical Seizures in Cats and Non-human Primates. (2017)
  • Author(s): Inoue T, Fujii M, Kida H, Yamakawa T, Maruta Y, Tokiwa T, He Y, Nomura S, Owada Y, Yamakawa T, and Michiyasu Suzuki M
  • Journal Title: Neurosci Res. Volume: in press
  • Acknowledgement Compliant
• [Journal Article] Motor training promotes both synaptic and intrinsic plasticity of layer II/III pyramidal neurons in the primary motor cortex. (2016)
  • Author(s): Kida H, Tsuda Y, Ito N, Yamamoto Y, Owada Y, Kamiya Y, Mitsushima D.
  • Journal Title: Cerebral Cortex Volume: in press Issue: 8 Pages: 3494-507
  • DOI: 10.1093/cercor/bhw134
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Motor Training Promotes Both Synaptic and Intrinsic Plasticity of Layer II/III Pyramidal Neurons in the Primary Motor Cortex (2016)
  • Author(s): Kida H, Tsuda Y, Ito N, Y,Yuji Owada, Kamiya Y, Mitsushima D
  • Journal Title: Cerebral Cortex Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Astrocyte-expressed FABP7 regulates dendritic morphology and excitatory synaptic function of cortical neurons. (2016)
  • Author(s): Ebrahimi M, Yamamoto Y, Sharifi K, Kida H, Kagawa Y, Yasumoto Y, Islam A, Miyazaki H, Shimamoto C, Maekawa M, Mitsushima D, Yoshikawa T, Owada Y.
  • Journal Title: Glia Volume: 64(1) Issue: 1 Pages: 48-62
  • DOI: 10.1002/glia.22902
  • Peer Reviewed / Open Access
• [Presentation] Motor training strengthens the glutamatergic synapses of layers V neurons in the primary motor cortex (2018)
  • Author(s): Hiroyuki Otaku, Hiroyuki Kida, Dai Mitsushima
  • Organizer: 日本生理学会
• [Presentation] Motor training promotes both synaptic and intrinsic plasticity of layer II/III pyramidal neurons in the primary motor cortex. (2017)
  • Author(s): 木田裕之 美津島大
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: アクトシティ―浜松（静岡県 浜松市）
  • Year and Date: 2017-03-27
  • Invited
• [Presentation] 一次運動野における AMPA/GABA シナプス可塑性による運動学習のメカニズム (2016)
  • Author(s): 木田裕之
  • Organizer: 平成28年度 生理学研究所研究会
  • Place of Presentation: 生理学研究所（愛知県 岡崎市）
  • Year and Date: 2016-12-07
  • Invited
• [Presentation] Motor training promotes both synaptic and intrinsic plasticity of layer II/III pyramidal neurons in the primary motor cortex. (2016)
  • Author(s): Kida H, Tsuda Y, Yamamoto Y, Owada Y and Mitsushima D.
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2016-11-15
  • Int'l Joint Research
• [Presentation] 一次運動野における AMPA/GABAシナプス可塑性による運動学習のメカニズム (2016)
  • Author(s): 木田裕之、津田廉正、山本由似、大和田祐二、美津島大
  • Organizer: 日本生理学会
  • Place of Presentation: 北海道 札幌市(札幌コンベンションセンター)
  • Year and Date: 2016-03-22
• [Presentation] 一次運動野における AMPA/GABAシナプス可塑性による運動学習のメカニズム (2015)
  • Author(s): 木田裕之、津田廉正、山本由似、大和田祐二、美津島大
  • Organizer: 日本生理学会中国四国地方会
  • Place of Presentation: 鳥取県 米子市(米子コンベンションセンター)
  • Year and Date: 2015-10-24