| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
To investigate the effect of voluntary movement in developmental period for cognitive function, we kept 3 week age mice in the environmental enrichment (EE) for 2 weeks. We examined AMPA receptor expression and Brain drive neurotrophic factor (BDNF) after in cingulate cortex after voluntary movement. The EE grope showed significantly increase of anti-anxiety behavior and inhibitory avoidance (IA) score, and positive correlation between IA score and the amount of movement. In addition, although AMPA receptor expression did not change, BDNF expression significantly increased in the EE group. These results suggest the trophic effect of voluntary movement in developmental period.
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