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Genetic factor for pattern of objectively measured daily physical activity

Research Project

Project/Area Number 15K01510
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Developmental mechanisms and the body works
Research InstitutionNational Institutes of Biomedical Innovation, Health and Nutrition

Principal Investigator

Murakami Haruka  国立研究開発法人医薬基盤・健康・栄養研究所, 国立健康・栄養研究所 身体活動研究部, 室長 (20344880)

Co-Investigator(Kenkyū-buntansha) tripette julien  お茶の水女子大学, 生活科学部, 学部教育研究協力員 (30747481)
山田 亮  京都大学, 医学(系)研究科(研究院), 助教授 (50301106)
川口 喬久  京都大学, 医学研究科, 研究員 (30566120)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords身体活動 / 遺伝子多型 / GWAS / 身体活動パターン / 10分バウト / Sedentary behavior
Outline of Final Research Achievements

It has been reported that genetic factors are partly involved in daily physical activity levels and exercise habit. We aimed to evaluate the daily physical activity pattern and to clarify the genetic factors for the physical activity pattern.
We developed analysis software to evaluate physical activity patterns and extracted various physical activity variables in 811 participants. About 6 million single nucleotide polymorphisms (SNPs) were examined to be associated with physical activity variables. Several SNPs were significantly related to the time spent in vigorous physical activity. The genes with/near these SNPs existed on pathways related to mitochondrial DNA replication and transcription. It was suggested that these pathways might be related to the amount of vigorous physical activity.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (22 results)

All 2018 2017 2016 2015

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Int'l Joint Research: 3 results,  Invited: 6 results) Book (2 results)

  • [Journal Article] Caffeine Consumption is Associated With Higher Level of Physical Activity in Japanese Women.2018

    • Author(s)
      Tripette J, Murakami H, Hara H, Kawakami R, Gando Y, Ohno H, Miyatake N, Miyachi M.
    • Journal Title

      Int J Sport Nutr Exerc Metab.

      Volume: in press Issue: 5 Pages: 0-0

    • DOI

      10.1123/ijsnem.2017-0428

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heritability estimates of endurance-related phenotypes: A systematic review and meta-analysis.2018

    • Author(s)
      Miyamoto-Mikami E, Zempo H, Fuku N, Kikuchi N, Miyachi M, Murakami H.
    • Journal Title

      Scandinavian Journal of Medicine and Science in Sports.

      Volume: 28 Issue: 3 Pages: 834-845

    • DOI

      10.1111/sms.12958

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retraction Notice to: <i>DRD2/ANKK1</i> gene polymorphism rs1800497 is associated with exercise habit in the period from childhood to adolescence in Japanese2017

    • Author(s)
      Murakami H, Fuku N, Kawakami R, Gando Y, Iemitsu M, Sanada K, Miyachi M
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 6 Issue: 2 Pages: 95-102

    • DOI

      10.7600/jpfsm.6.95

    • NAID

      130005464536

    • ISSN
      2186-8123, 2186-8131
    • Year and Date
      2017-03-25
    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Epistasis, physical capacity-related genes and exceptional longevity: FNDC5 gene interactions with candidate genes FOXOA3 and APOE2017

    • Author(s)
      Fuku Noriyuki、D?az-Pe?a Roberto、Arai Yasumichi、Abe Yukiko、Zempo Hirofumi、Naito Hisashi、Murakami Haruka、Miyachi Motohiko、Spuch Carlos、Serra-Rexach Jos? A.、Emanuele Enzo、Hirose Nobuyoshi、Lucia Alejandro
    • Journal Title

      BMC Genomics

      Volume: 18 Issue: S8 Pages: 803-803

    • DOI

      10.1186/s12864-017-4194-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The contribution of Nintendo Wii Fit series in the field of health: a systematic review and meta-analysis.2017

    • Author(s)
      Tripette J, Murakami H, Ryan KR, Ohta Y, Miyachi M.
    • Journal Title

      PeerJ.

      Volume: 5 Pages: e3600-e3600

    • DOI

      10.7717/peerj.3600

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heritability estimates of muscle strength-related phenotypes: A systematic review and meta-analysis.2017

    • Author(s)
      Zempo H, Miyamoto-Mikami E, Kikuchi N, Fuku N, Miyachi M, Murakami H.
    • Journal Title

      Scandinavian Journal of Medicine & Science in Sports

      Volume: 印刷中 Issue: 12 Pages: 1537-1546

    • DOI

      10.1111/sms.12804

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heritability of physical fitness and exercise behavior2016

    • Author(s)
      村上晴香, 膳法浩史, 宮本(三上)恵里, 菊池直樹, 福典之.
    • Journal Title

      Japanese Journal of Physical Fitness and Sports Medicine

      Volume: 65 Issue: 3 Pages: 277-286

    • DOI

      10.7600/jspfsm.65.277

    • NAID

      130005151198

    • ISSN
      0039-906X, 1881-4751
    • Related Report
      2017 Annual Research Report
  • [Journal Article] 運動能力・運動行動の遺伝率2016

    • Author(s)
      村上晴香, 膳法浩史, 宮本(三上)恵里, 菊池直樹, 福典之
    • Journal Title

      体力科学

      Volume: 63 Pages: 277-286

    • NAID

      130005151198

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Open Access
  • [Journal Article] Accuracy of Wearable Devices for Estimating Total Energy Expenditure: Comparison With Metabolic Chamber and Doubly Labeled Water Method.2016

    • Author(s)
      Murakami H, Kawakami R, Nakae S, Nakata Y, Ishikawa-Takata K, Tanaka S, Miyachi M.
    • Journal Title

      JAMA Intern Med

      Volume: 176 Issue: 5 Pages: 702-3

    • DOI

      10.1001/jamainternmed.2016.0152

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 郵便番号を使って評価された自宅近隣施設環境と活動量計により評価された身体活動量の横断的関連:佐久コホートスタディ2016

    • Author(s)
      安永明智,村上晴香,森田明美,出浦喜丈,饗場直美,渡邊昌,宮地元彦
    • Journal Title

      日本公衆衛生学雑誌

      Volume: 未定

    • NAID

      130005158128

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Genetic Factor of Daily Physical Activity, Exercise behavior, and Physical fitness2017

    • Author(s)
      H Murakami
    • Organizer
      早稲田大学アクティヴ・エイジング国際学術シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2017-02-25
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Genetic Factors of Daily Physical Activity, Exercise behavior, and Physical fitness.2017

    • Author(s)
      Murakami H.
    • Organizer
      The 4th Institute of Advanced Active Aging Research Symposium.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 大腸がん予防に関する疫学研究2017

    • Author(s)
      村上晴香, 川上諒子, 澤田亨, 宮地元彦.
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 身体活動・運動行動の個人差をもたらす要因を遺伝要因から探る2016

    • Author(s)
      村上晴香
    • Organizer
      第4回日本介護福祉・健康づくり学会大会
    • Place of Presentation
      千葉
    • Year and Date
      2016-11-05
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 日常身体活動量に及ぼすカフェインと遺伝要因との関連2016

    • Author(s)
      村上晴香, ジュリアン・トリペッテ, 川上諒子, 丸藤祐子, 家光素行, 真田樹義, 宮地元彦
    • Organizer
      第71回日本体力医学会大会
    • Place of Presentation
      岩手
    • Year and Date
      2016-09-24
    • Related Report
      2016 Research-status Report
  • [Presentation] Validation of Physical Activity Estimated Using Wearable Devices under Free-living Conditions2016

    • Author(s)
      H Murakami, R Kawakami, S Nakae, Y Yamada, Y Nakata, K I-Takata, S Tanaka, M Miyachi
    • Organizer
      American College of Sports Medicine, 63rd Annual Meeting
    • Place of Presentation
      Boston
    • Year and Date
      2016-06-02
    • Related Report
      2016 Research-status Report
  • [Presentation] アスリートにおけるドーパミン受容体D2遺伝子多型の関連2015

    • Author(s)
      村上晴香, 福典之, 三上恵里, 川上諒子, 丸藤祐子, 家光素行, 真田樹義, 宮地元彦
    • Organizer
      第70回日本体力医学会大会
    • Place of Presentation
      和歌山
    • Year and Date
      2015-09-20
    • Related Report
      2015 Research-status Report
  • [Presentation] シンポジウム15:遺伝情報を利用したタレント発掘・育成の可能性:運動行動・運動能力の遺伝率2015

    • Author(s)
      村上晴香
    • Organizer
      第70回日本体力医学会大会
    • Place of Presentation
      和歌山
    • Year and Date
      2015-09-19
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 遺伝子の疫学2015

    • Author(s)
      村上晴香
    • Organizer
      第1回運動疫学の集い
    • Place of Presentation
      和歌山
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Association between DRD2 Genotypes and Exercise Habits2015

    • Author(s)
      Murakami H, Fuku N, Iemitsu M, Sanada K, Kawakami R, Gando Y, Miyachi M.
    • Organizer
      62st American College of Sports Medicine
    • Place of Presentation
      San Diego
    • Year and Date
      2015-05-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] 健康・スポーツ科学研究2017

    • Author(s)
      身体活動・運動促進のためのポピュレーションアプローチ
    • Total Pages
      267
    • Publisher
      放送大学教育振興会
    • ISBN
      4595140835
    • Related Report
      2017 Annual Research Report
  • [Book] Physical activity, exercise, sedentary behavior and health.(Relationship of cardiorespiratory fitness and obesity genes to metabolic syndrome in adult Japanese Men.)2015

    • Author(s)
      Kiyoshi S, Iemitsu M, Murakami H, Kawakami R, Gando Y, Kawano H, Suzuki K, Higuchi M, Miyachi M.
    • Total Pages
      336
    • Publisher
      Springer
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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