| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
This study evaluated the effects of the dietary intake of functional lipids on hindlimb casting- and denervation-induced skeletal muscle atrophy in rats. Consequently, our results demonstrated that dietary intake of medium-chain fatty acids partly prevented the immobilization-induced decreases in muscle mass and muscle protein content by inhibiting the ubiquitin-proteasome pathway, suggesting that the functional lipid may be a new nutritional strategy to attenuate immobilization-induced muscle atrophy.
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