Preventive effects of functional lipids on immobilization-induced muscle atrophy
| Project/Area Number |
15K01615
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Terada Shin 東京大学, 大学院総合文化研究科, 准教授 (00460048)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 中鎖脂肪酸 / 短鎖脂肪酸 / 廃用性筋萎縮 / ユビキチンリガーゼ / ラット / 高たんぱく質食 / 除神経 / 骨格筋 / 機能性脂質 / マウス |
|---|
| Outline of Final Research Achievements |
This study evaluated the effects of the dietary intake of functional lipids on hindlimb casting- and denervation-induced skeletal muscle atrophy in rats. Consequently, our results demonstrated that dietary intake of medium-chain fatty acids partly prevented the immobilization-induced decreases in muscle mass and muscle protein content by inhibiting the ubiquitin-proteasome pathway, suggesting that the functional lipid may be a new nutritional strategy to attenuate immobilization-induced muscle atrophy.
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Report
(4 results)
Research Products
(43 results)
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[Book] スポーツ栄養学2017
Author(s)
寺田 新
Total Pages
256
Publisher
東京大学出版会
ISBN
4130527061
Related Report
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