Role of systemic angiotensin II in exercise-enhanced neurogenesis in adult hippocampus.
| Project/Area Number |
15K01618
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Tottori University |
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Principal Investigator |
Mukuda Takao 鳥取大学, 医学部, 講師 (60346335)
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| Co-Investigator(Kenkyū-buntansha) |
古川 康雄 広島大学, 総合科学研究科, 教授 (40209169)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 海馬 / 神経新生 / 血液脳関門 / 血管透過性 / アンギオテンシンII / 血管内皮増殖因子 / 1型受容体 / VEGF / 介在ニューロン / アンギオテンシンＩＩ / ＶＥＧＦ / アストロサイト |
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| Outline of Final Research Achievements |
Running exercise induced an increased level of angiotensin II (Ang II) in the systemic circulation, which activated the type 1 receptor of Ang II (AT1R) and enhanced adult hippocampal neurogenesis. Further, activation of AT1R stimulated by Ang II promoted the synthesis of a potent neurogenic molecule, vascular endothelial cell growth factor (VEGF) in the hippocampal astrocytes. Along with the neurogenic effect, we found a tendency that Ang II increases vascular permeability of the blood－brain barrier in the hippocampus, amygdala and some cortical areas.
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Report
(4 results)
Research Products
(9 results)
