| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Running exercise induced an increased level of angiotensin II (Ang II) in the systemic circulation, which activated the type 1 receptor of Ang II (AT1R) and enhanced adult hippocampal neurogenesis. Further, activation of AT1R stimulated by Ang II promoted the synthesis of a potent neurogenic molecule, vascular endothelial cell growth factor (VEGF) in the hippocampal astrocytes. Along with the neurogenic effect, we found a tendency that Ang II increases vascular permeability of the blood－brain barrier in the hippocampus, amygdala and some cortical areas.
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