Can dietary nitrate reduce decline of contractile force and sarcoplasmic reticulum function in rat fast-twitch muscle following eccentric contraction?
| Project/Area Number |
15K01622
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
和田 正信 広島大学, 総合科学研究科, 教授 (80220961)
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| Co-Investigator(Renkei-kenkyūsha) |
FUKUDA JUN 宮崎大学, 教育学部, 准教授 (30717905)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 伸張性収縮 / 硝酸塩摂取 / 筋小胞体機能 / タンパク質修飾 |
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| Outline of Final Research Achievements |
We examined investigate whether dietary nitrate supplementation would alleviate a decline in muscle contractile properties and sarcoplasmic reticulum (SR) Ca2+ handling following eccentric contraction (ECC) in rat fast-twitch muscles. ECC-induced significant decreases of up to 3-days in the maximal tetanic force and of no nitrate supplementation in the SR Ca2+ uptake rate weren’t observed in more than 6 and 3 days nitrate supplementation, respectively. Dietary nitrate of 0 to 6 days resulted in no alterations in protein content of ryanodine receptor (RyR) and dihydropyridine receptor (DHPR) between ECC-treated and contralateral muscles. However, It has been shown that impairments of RyR and DHPR in with and without ECC-treated muscles resulted from the dietary nitrate.
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Report
(4 results)
Research Products
(2 results)
