| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
To elucidate molecular mechanisms underlying ameliorating effects of exercise on diabetes-related inflammation, we examined crosstalk between the Toll-like receptor (TLR) signaling and hexosamine biosynthetic pathway in macrophages. We obtained the following insights: 1) the hexosamine biosynthetic pathway suppressed rather than promoted the macrophage TLR signaling and pro-inflammatory responses via O-linked N-acetylglucosamine (O-GlcNAc) modification; 2) type 2 diabetic mice showed reduced rather than exacerbated macrophage pro-inflammatory responses, suggesting that type 2 diabetes impaired capability to protect the host from infection; 3) O-GlcNAc modification did not contribute to the diabetes-related suppression of macrophage pro-inflammatory responses; 4) exercise improved macrophage pro-inflammatory responses, which suggested that exercise is beneficial to host defense against infection.
|
