Ameliorating Effect of Exercise on Diabetes-Related Inflammation: A Possible Role for Macrophage Hexosamine Biosynthetic Pathway
Project/Area Number |
15K01627
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Sports science
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Research Institution | Kyorin University |
Principal Investigator |
SHIRATO Ken 杏林大学, 医学部, 助教 (60559384)
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Co-Investigator(Renkei-kenkyūsha) |
KIZAKI Takako 杏林大学, 医学部, 教授 (00322446)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 2型糖尿病 / 炎症 / Toll様受容体 / シグナル伝達 / ヘキソサミン代謝経路 / O-結合型N-アセチルグルコサミン / 感染防御 / 運動 / マクロファージ / 糖尿病 / 高血糖 / 糖鎖修飾 / インスリン |
Outline of Final Research Achievements |
To elucidate molecular mechanisms underlying ameliorating effects of exercise on diabetes-related inflammation, we examined crosstalk between the Toll-like receptor (TLR) signaling and hexosamine biosynthetic pathway in macrophages. We obtained the following insights: 1) the hexosamine biosynthetic pathway suppressed rather than promoted the macrophage TLR signaling and pro-inflammatory responses via O-linked N-acetylglucosamine (O-GlcNAc) modification; 2) type 2 diabetic mice showed reduced rather than exacerbated macrophage pro-inflammatory responses, suggesting that type 2 diabetes impaired capability to protect the host from infection; 3) O-GlcNAc modification did not contribute to the diabetes-related suppression of macrophage pro-inflammatory responses; 4) exercise improved macrophage pro-inflammatory responses, which suggested that exercise is beneficial to host defense against infection.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Cerebral artery blood flow and oxygenation in the frontal lobe region in response to a judo chokehold (shimewaza)2016
Author(s)
Haga S, Sakurai T, Hamaoka T, Esaki K, Ueya K, Toshinai K, Miyazaki H, Ogasawara J, Shirato K, Hashimoto N, Katsumura T, Nioka S, Chance B, Yamaguchi I, Kizaki T, Ohno H
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Journal Title
Journal of Exercise, Sports & Orthopedics
Volume: 3
Related Report
Peer Reviewed / Open Access
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[Presentation] Enzyme-treated asparagus extract has suppressive effect on ultraviolet-B radiation-induced NF-κB nuclear translocation in normal human dermal fibroblasts2017
Author(s)
Shirato K, Takanari J, Misu M, Koda T, Sakurai T, Ogasawara J, Ishibashi Y, Imaizumi K, Ohno H, Kizaki T
Organizer
The 25th International Congress on Nutrition and Integrative Medicine (ICNIM2017) (Sapporo, Jpan)
Related Report
Int'l Joint Research
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[Presentation] Voluntary exercise reduces O-linked N-acetylglucosamine levels in murine macrophages2015
Author(s)
Shirato K, Sakurai T, Ogasawara J, Ishibashi Y, Kato H, Izawa T, Ohira Y, Imaizumi K, Ohno H, Kizaki T
Organizer
The 16th International Biochemistry of Exercise Conference (IBEC2015)
Place of Presentation
Sao Paulo, Brazil
Year and Date
2015-09-07
Related Report
Int'l Joint Research
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[Presentation] The TGF-β-TIMP1 pathway, which inhibits glucose uptake in adipocytes, is attenuated by exercise training2015
Author(s)
Sakurai T, Ogasawara J, Shirato K, Ishibashi Y, Kato H, Izawa T, Ohira Y, Ohno H, Kizaki T
Organizer
The 16th International Biochemistry of Exercise Conference (IBEC2015)
Place of Presentation
Sao Paulo, Brazil
Year and Date
2015-09-07
Related Report
Int'l Joint Research
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