effect of combination microcurrent electrical neuromuscular stimulation and hyperbaric oxygen therapy on the regeneration of injured skeletal muscle

Research Project

Project/Area Number	15K01632
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Sports science
Research Institution	St. Marianna University School of Medicine
Principal Investigator	Fujiya Hiroto 聖マリアンナ医科大学, 医学部, 教授 (50278008)
Co-Investigator(Renkei-kenkyūsha)	GOTO Katsumasa 豊橋創造大学, 大学院・健康科学研究科, 教授 (70239961) KUROSAKA Mitsutoshi 聖マリアンナ医科大学, 医学部, 助教 (40553970)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	微弱電流 / 高気圧酸素 / 骨格筋損傷 / 再生 / 修復
Outline of Final Research Achievements	We investigated, in an animal model of skeletal muscle injury, whether microcurrent electrical neuromuscular stimulation (MENS) and hyperbaric oxygen therapy (HBO) used in combination (MENS and HBO) enhances the restorative benefits conferred by these treatments alone. Two weeks after the treatment, both the mean fiber cross-sectional area (CSA) and percentage increase in the fiber CSA were significantly greater by the combination therapy. Our data indicate that combination MENS and HBO therapy enhances regeneration of injured skeletal muscle more than these treatments alone.