Fasting-related response of skeletal muscles with exercise

Research Project

Project/Area Number	15K01640
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Sports science
Research Institution	Hiroshima Shudo University
Principal Investigator	Ogata Tomonori 広島修道大学, 人間環境学部, 教授 (30434343)
Co-Investigator(Kenkyū-buntansha)	大石康晴熊本大学, 教育学部, 教授 (10203704)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	骨格筋 / 絶食 / 応答 / 運動
Outline of Final Research Achievements	The purpose of this study is to determine the effects of fasting to exercise-related physical response and adaptation. This study designed two exercise models using treadmill running under fasting condition. One is low intensity endurance exercise (30 m/min, 50min), and the other is high intensity exercise after 24 hours fasting. We analyzed the expression of autophagy marker (LC3-II), heat shock proteins (HSPs) and mTOR signaling pathway in plantaris and soleus muscles. In plantaris muscle, LC3-II was increased by 24 hours fasting, but no additional change with both endurance and high intensity exercise. There was no effect on expression of HSP72 and mTOR signaling by fasting in both types of exercise model.