| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We developed a simultaneous quantification method of several stress markers including oxidative stress which is involved in diseases such as diabetes, hypertension, and cancer by using LC/MS/MS. Administration of foods containing 4% or 8% sodium chloride to spontaneously hypertensive rat (SHR) and Wistor kyoto (WKY) rat decreased KYA concentration in both SHR and WKY plasmas, and that of food containing 4% sodium chloride increased SDMA concentration in SHR plasma, suggesting the possibility that KYA and ADMA could be a salt-sensitive stress marker.
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