| Project/Area Number |
15K01662
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大谷 悟 了徳寺大学, 健康科学部, 教授 (70211795)
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| Research Collaborator |
YAMAGUCHI Takuji
HU Ailing
HARADA Yoshinao
KATOU Masayuki
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 半夏厚朴湯 / 攻撃性 / 隔離ストレス / セロトニン / ドーパミン / IL-6 / ストレス / 攻撃・社会行動 / 神経伝達物質 / サイトカイン / 口臭 / コルチゾール / クロモグラニンA / 不安・うつ / グルタミン酸受容体 / 睡眠障害 / 漢方薬 |
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| Outline of Final Research Achievements |
Stress is involved in clinical conditions of several diseases in the modern society. Especially, mental diseases such as adjustment disorder, depression, and chronic fatigue syndrome caused by chronic social stress are recognized as serious social problems. In the present study, we demonstrated the effect of Hangekobokuto (HKT) for amelioration of aggressiveness and social behavior using mice as stress models.
HKT dose-dependently controlled the aggressive behavior induced by isolation stress. It was confirmed that the effect disappeared by the administration of 5HT1A receptor antagonist. And the blood corticosterone decreased by the administration of HKT. Serotonin and dopamine in the prefrontal region increased by the administration of HKT. IL-6 in the brain stem decreased dose-dependent manner. It was confirmed that HKT has effects not only on the central action but also on the systemic symptoms caused by stress. It was suggested the mechanism acted on the serotonin system.
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