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Effects of social stress on emotional disorders and effects of the Traditonal Kampo medicine

Research Project

Project/Area Number 15K01662
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionJuntendo University

Principal Investigator

KOBAYASHI Hiroyuki  順天堂大学, 医学部, 教授 (50245768)

Co-Investigator(Kenkyū-buntansha) 大谷 悟  了徳寺大学, 健康科学部, 教授 (70211795)
Research Collaborator YAMAGUCHI Takuji  
HU Ailing  
HARADA Yoshinao  
KATOU Masayuki  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords半夏厚朴湯 / 攻撃性 / 隔離ストレス / セロトニン / ドーパミン / IL-6 / ストレス / 攻撃・社会行動 / 神経伝達物質 / サイトカイン / 口臭 / コルチゾール / クロモグラニンA / 不安・うつ / グルタミン酸受容体 / 睡眠障害 / 漢方薬
Outline of Final Research Achievements

Stress is involved in clinical conditions of several diseases in the modern society. Especially, mental diseases such as adjustment disorder, depression, and chronic fatigue syndrome caused by chronic social stress are recognized as serious social problems. In the present study, we demonstrated the effect of Hangekobokuto (HKT) for amelioration of aggressiveness and social behavior using mice as stress models.
HKT dose-dependently controlled the aggressive behavior induced by isolation stress. It was confirmed that the effect disappeared by the administration of 5HT1A receptor antagonist. And the blood corticosterone decreased by the administration of HKT. Serotonin and dopamine in the prefrontal region increased by the administration of HKT. IL-6 in the brain stem decreased dose-dependent manner. It was confirmed that HKT has effects not only on the central action but also on the systemic symptoms caused by stress. It was suggested the mechanism acted on the serotonin system.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2018 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Effect of hangekobokuto for amelioration of aggressiveness and social behavior in socially isolated mice.2018

    • Author(s)
      Yoshinao Harada, Takuji Yamaguchi, Ailing Hu, Satoru Otani, Cheolsun Han, Yumiko Kurihara, Hiroyuki Kobayashi, Hajime Arai
    • Journal Title

      Traditional & Kampo Medicine

      Volume: 印刷中 Issue: 2 Pages: 75-82

    • DOI

      10.1002/tkm2.1095

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 隔離ストレス誘発攻撃行動に対する半夏厚朴湯の効果2016

    • Author(s)
      原田佳尚、山口琢児、胡 愛玲、韓 哲舜、大谷 悟、小林弘幸
    • Organizer
      第67回日本東洋医学会総会
    • Place of Presentation
      香川県高松市
    • Year and Date
      2016-06-03
    • Related Report
      2016 Research-status Report
  • [Presentation] 隔離ストレス誘発情動障害に対する香蘇散の効果2016

    • Author(s)
      韓 哲舜、山口琢児、胡 愛玲、原田佳尚、大谷 悟、小林弘幸
    • Organizer
      第67回日本東洋医学会総会
    • Place of Presentation
      香川県高松市
    • Year and Date
      2016-06-03
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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