New biomarkers for primary prevention of lifestyle diseases in adolescence

• Project/Area Number: 15K01678
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Tohoku University
• Principal Investigator: Yamamoto Saori 東北大学, 高度教養教育・学生支援機構, 助教 (40707155)
• Co-Investigator(Kenkyū-buntansha): 佐藤 公雄 東北大学, 高度教養教育・学生支援機構, 准教授 (80436120)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 循環器・高血圧 / 肺高血圧症 / 医歯薬学 / 内科系臨床医学 / 循環器内科学 / 分子血管学 / 臨床応用研究 / 基礎医学 / 動脈硬化 / 保健管理 / バイオマーカー / リスクファクター / 予防

Outline of Final Research Achievements

The causes of arteriosclerosis include risk factors such as hypertension, diabetes, dyslipidemia, smoking, obesity, and aging. Indeed, it is found from the accumulated data of student health examination conducted every year at Tohoku University that the proportion of students with arteriosclerosis risk factors (especially obesity) is increasing year by year. Therefore, we planned to develop a novel biomarker for early diagnosis of high-risk students who may develop cardiovascular disease, especially coronary artery disease. In the present study, we have performed preliminary analysis in the levels of plasma cyclophilin A in juvenile atherosclerotic patients.

Research Products

• [Journal Article] SmgGDS as a crucial mediator of the inhibitory effects of statins on cardiac hypertrophy and fibrosis -Novel mechanism of the pleiotropic effects of statins- (2016)
  • Author(s): Kudo S, Satoh K, Nogi M, Suzuki K, Sunamura S, Omura J, Kikuchi N, Kurosawa R, Satoh T, Minami T, Ikeda S, Miyata S, Shimokawa H.
  • Journal Title: Hypertension Volume: 67 Issue: 5 Pages: 878-889
  • DOI: 10.1161/hypertensionaha.115.07089
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Statins up-regulate SmgGDS through β1-integrin/Akt1 pathway in endothelial cells. (2016)
  • Author(s): Minami T, Satoh K, Nogi M, Kudo S, Miyata S, Tanaka S, Shimokawa H. Statins up-regulate SmgGDS through β1-integrin/Akt1 pathway in endothelial cells.
  • Journal Title: Cardiovasc Res. Volume: 109 Issue: 1 Pages: 151-161
  • DOI: 10.1093/cvr/cvv253
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] RhoA/Rho-kinase in the cardiovascular system. (2016)
  • Author(s): Shimokawa H, Sunamura S, Satoh K.
  • Journal Title: Circ Res. Volume: 118 Issue: 2 Pages: 352-366
  • DOI: 10.1161/circresaha.115.306532
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Basigin promotes cardiac fibrosis and failure in response to chronic pressure-overload in mice. (2016)
  • Author(s): Suzuki K, Satoh K, Ikeda S, Sunamura S, Otsuki T, Satoh T, Kikuchi N, Omura J, Kurosawa R, Nogi M, Numano K, Sugimura K, Aoki T, Tatebe S, Miyata S, Mukherjee R, Spinale FG, Kadomatsu K, Shimokawa H.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 36 Issue: 4 Pages: 636-646
  • DOI: 10.1161/atvbaha.115.306686
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Thrombin-activatable fibrinolysis inhibitor in chronic thromboembolic pulmonary hypertension. (2016)
  • Author(s): Yaoita N, Satoh K, Satoh T, Sugimura K, Tatebe S, Yamamoto S, Aoki T, Miura M, Miyata S, Kawamura T, Horiuchi H, Fukumoto Y, Shimokawa H.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 36 Issue: 6 Pages: 1293-1301
  • DOI: 10.1161/atvbaha.115.306845
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Multiple Beneficial Effects of Balloon Pulmonary Angioplasty in Patients With Chronic Thromboembolic Pulmonary Hypertension (2016)
  • Author(s): Tatebe S, Sugimura K, Aoki T, Miura M, Nochioka K, Miyamichi-Yamamoto S, Yaoita N, Suzuki H, Sato H, Satoh K, Fukumoto Y, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 80 Issue: 4 Pages: 980-988
  • DOI: 10.1253/circj.CJ-15-1212
  • NAID: 130005139581
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Balloon Pulmonary Angioplasty Improves Biventricular Functions and Pulmonary Flow in Chronic Thromboembolic Pulmonary Hypertension (2016)
  • Author(s): Sato H, Ota H, Sugimura K, Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Satoh K, Takase K, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 80 Issue: 6 Pages: 1470-1477
  • DOI: 10.1253/circj.CJ-15-1187
  • NAID: 130005153583
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] PDE1C negatively regulates growth factor receptor degradation and promotes vascular smooth muscle cell proliferation. (2015)
  • Author(s): Satoh K, Kikuchi N, Kurosawa R, Shimokawa H.
  • Journal Title: Circ Res. Volume: 116 Issue: 7 Pages: 1098-1100
  • DOI: 10.1161/circresaha.115.306139
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cyclophilin A in Cardiovascular Homeostasis and Diseases (2015)
  • Author(s): Satoh K
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 235 Issue: 1 Pages: 1-15
  • DOI: 10.1620/tjem.235.1
  • NAID: 130004822422
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Rho-kinase inhibition during early cardiac development causes arrhythmogenic right ventricular cardiomyopathy in mice. (2015)
  • Author(s): Ellawindy A, Satoh K, Sunamura S, Kikuchi N, Suzuki K, Minami T, Ikeda S, Tanaka S, Shimizu T, Enkhjargal B, Miyata S, Taguchi Y, Handoh T, Kobayashi K, Kobayashi K, Nakayama K, Miura M, Shimokawa H.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 35 Issue: 10 Pages: 2172-2184
  • DOI: 10.1161/atvbaha.115.305872
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 2015 ATVB plenary lecture: translational research on Rho-kinase in cardiovascular medicine. (2015)
  • Author(s): Shimokawa H, Satoh K.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 35 Issue: 8 Pages: 1756-1769
  • DOI: 10.1161/atvbaha.115.305353
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Light and dark of reactive oxygen species for vascular function. (2015)
  • Author(s): Shimokawa H, Satoh K.
  • Journal Title: J Cardiovasc Pharmacol. Volume: 65 Issue: 5 Pages: 412-418
  • DOI: 10.1097/fjc.0000000000000159
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 当科におけるFabry病の診療について (2015)
  • Author(s): 山本沙織、杉村宏一郎、青木竜男、建部俊介、三浦正暢、鈴木秀明、矢尾板信裕、佐藤遥、佐藤公雄、下川宏明
  • Organizer: 第56回日本脈管学会総会
  • Place of Presentation: 虎ノ門ヒルズフォーラム（東京都港区）
  • Year and Date: 2015-10-29
• [Presentation] 末梢型慢性血栓塞栓性肺高血圧症の病態形成 ―OFDIによる検討― (2015)
  • Author(s): 神津克也、青木竜男、杉村宏一郎、三浦正暢、建部俊介、山本沙織、矢尾板信裕、鈴木秀明、佐藤 遙、佐藤公雄、下川宏明
  • Organizer: 第56回日本脈管学会総会
  • Place of Presentation: 虎ノ門ヒルズフォーラム（東京都港区）
  • Year and Date: 2015-10-29
• [Book] 循環器専門医 「喫煙と循環器疾患up to date: 喫煙による酸化ストレスと動脈硬化性疾患」 (2016)
  • Author(s): 佐藤 公雄.
  • Total Pages: 5
  • Publisher: 南江堂
• [Book] 循環器内科 特集/循環器疾患と分子遺伝学 肺高血圧症の分子基盤 第77巻第４号 (2015)
  • Author(s): 佐藤 公雄、下川 宏明.
  • Total Pages: 7
  • Publisher: 科学評論社
• [Remarks] 東北大学循環器内科ホームページ
  • URL: http://www.cardio.med.tohoku.ac.jp