| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
We examined whether myocardial infarction (MI) causes reduction of bone mass and the effect of exercise training for bone in mice, and if so, what molecular mechanisms are involved.
We created experimental MI model in 16 week-old male apolipoprotein E- deficient mice . We also performed sham operations in other mice. MI group were randomly assigned to exercise group and sedentary group. Exercise training with treadmill was performed from 1-week after operation to 8 weeks. At 8 weeks after the operation, bone parameters of the femur were measured by quantitative-CT. The bone mineral density of the femur was significantly decreased in the MI-Sed group as compared with the sham group (P<0.001), and the MI-Ex group (P<0.05). The present study demonstrates for the first time that post-infarction HF reduces bone mineral density and exercise training prevents the reduction of bone mineral density in apolipoprotein E-deficient mice in vivo.
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