Elucidation of the transformation mechanisms of a cognitive function and activity in brain reward prcessing after bariatric surgery in obesity
Project/Area Number |
15K01703
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Applied health science
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Research Institution | Chiba University |
Principal Investigator |
Matsumoto Junko 千葉大学, 大学院医学研究院, 特任助教 (60722262)
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Co-Investigator(Kenkyū-buntansha) |
平野 好幸 千葉大学, 子どものこころの発達教育研究センター, 教授 (50386843)
徳山 宏丈 千葉大学, 大学院医学研究院, 特任助教 (90385039)
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Research Collaborator |
YOKOTE Koutaro
ONO Hiraku
KITAHARA Aya
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Project Period (FY) |
2015-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 高度肥満症 / 肥満外科手術 / 認知機能 / 脳機能 / 脳形態 / 肥満症外科手術 / 肥満症外科治療 / 高度肥満 / 肥満外科治療 |
Outline of Final Research Achievements |
The aim of this study was to investigate whether the cognitive function such as set-shifting, decision-making abilities and reward processing during the monetary incentive delayed (MID) task using functional magnetic resonance imaging (fMRI) and volumetric analysis, were altered in patients with obesity who undergoing bariatric surgery (BS) and non-surgical patients (NS) before, after six months, and at 18-month follow up. Compared with NS group, BMI in BS individuals who underwent bariatric surgery was significantly lower than in the NS at the six months after, and at 18-month follow-up from baseline. No significant differences among intelligence quotient, cognitive function such as set-shifting and decision-making abilities in BS and NS were observed. Response time during MID task was not changed at six months after surgery at interim analysis. However, bilateral thalamus and left putamen and amygdala activation tended to be increased in the prospect reward phase
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Academic Significance and Societal Importance of the Research Achievements |
肥満外科手術によって、肥満症患者の自尊感情やQOL、認知機能の改善が見込まれることが報告されている。他方、肥満症患者の味覚と嗅覚連合野の活動が外科手術後に減少していることから、食への欲求の減少が、食品写真課題を用いたfMRIによる研究で報告されている。しかしながら、わが国において、報酬系自体の活動変化と認知的制御を伴っているかどうかは未だ確認されていない。その点で、本研究の意義は大きい。 今回の結果は、肥満症患者の外科手術後の認知機能の改善は見られず、さらに、食への欲求に関連する脳の報酬系活動は依然として増加傾向にあることが示唆されたことから、今後、術後の包括的アプローチを再考する必要がある。
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Report
(5 results)
Research Products
(36 results)
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[Journal Article] A single-arm pilot study of guided self-help treatment based cognitive behavioral therapy for bulimia nervosa in Japanese clinical settings2018
Author(s)
Setsu R, Asano K, Numata N, Tanaka M, Ibuki H, Yamamoto T, Uragami R, Matsumoto J, Hirano Y, Iyo M, Shimizu E, Nakazato M.
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Journal Title
BMC Res Notes.
Volume: Apr 25;11(1)
Issue: 1
Pages: 257-257
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Does cognitive behavioral therapy alter mental defeat and cognitive flexibility in patients with panic disorder?2018
Author(s)
Nagata S , Seki Y, Shibuya T, Yokoo M, Murata T, Hiramatsu Y, Yamada F, Ibuki H, Minamitani N, Yoshinaga N, Kusunoki M, Inada Y, Kawasoe N, Adachi S, Oshiro K, Matsuzawa D, Hirano Y, Yoshimura K, Nakazato M, Iyo M, Nakagawa A, Shimizu E.
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Journal Title
BMC Res Notes.
Volume: 11
Issue: 1
Pages: 23-23
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Reliability and validity of the Japanese version of the Obsessive-Compulsive Inventory-Revised (OCI-R).2018
Author(s)
Koike H, Tsuchiyagaito A, Hirano Y, Oshima F, Asano K, Sugiura Y, Kobori O, Ishikawa R, Nishinaka H, Shimizu E, Nakagawa A.
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Journal Title
Curr Psychol, in press
Volume: -
Related Report
Peer Reviewed
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[Journal Article] Gender-specific associations of depression and anxiety symptoms with mental rotation.2018
Author(s)
Oshiyama C, Sutoh C, Miwa H, Okabayashi S, Hamada H, Matsuzawa D, Hirano Y, Takahashi T, Niwa S, Honda M, Sakatsume K, Nishimura T, Shimizu E
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Journal Title
J Affect Disord, in press
Volume: -
Pages: 277-284
DOI
Related Report
Peer Reviewed
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[Journal Article] Cognitive-behavioral therapy for obsessive-compulsive disorder with and without autism spectrum disorder: gray matter differences associated with poor outcome.2017
Author(s)
Tsuchiyagaito A, Hirano Y, Asano K, Oshima F, Nagaoka S, Takebayashi Y, Matsumoto K, Masuda Y, Iyo M, Shimizu E, Nakagawa A.
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Journal Title
Front Psychiatry
Volume: 8
Pages: 143-143
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Increased subjective distaste and altered insula activity to umami tastants in patients with bulimia nervosa.2017
Author(s)
Setsu R, Hirano Y, Tokunaga M, Takahashi T, Numata N, Matsumoto K, Masuda Y, Matsuzawa D, Iyo M, Shimizu E, Nakazato M.
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Journal Title
Front Psychiatry.
Volume: 8
Pages: 172-172
DOI
Related Report
Peer Reviewed
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[Journal Article] Relationship between symptom dimensions and brain morphology in obsessive-compulsive disorder2017
Author(s)
Hirose M, Hirano Y, Nemoto K, Sutoh C, Asano K, Miyata H, Matsumoto J, Nakazato M, Matsumoto K, Masuda Y, Iyo M, Shimizu E, Nakagawa A.
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Journal Title
Brain Imaging and Behavior
Volume: 印刷中
Issue: 5
Pages: 1326-33
DOI
Related Report
Peer Reviewed
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[Journal Article] Altered serum level of matrix metalloproteinase-9 and its association with decision-making in eating disorders2017
Author(s)
Matsumoto J, Hirano Y, Hashimoto K, Ishima T, Kanahara N, Niitsu T, Shiina A, Hashimoto T, MD, Sato Y, Yokote K, Murano S, KimuraH, Hosoda Y, Shimizu E, Iyo M, and Nakazato M
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Journal Title
Psychiatry and Clinical Neurosciences
Volume: 71
Issue: 2
Pages: 124-134
DOI
Related Report
Peer Reviewed
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[Journal Article] Comparison in decision-making between bulimia nervosa, anorexia nervosa, and healthy women: influence of mood status and pathological eating concerns2015
Author(s)
Matsumoto J, Hirano Y, Numata N, Matsuzawa D, Murano S, Yokote K, Iyo M, Shimizu E, Nakazato M.
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Journal Title
J Eat Disord
Volume: 3
Issue: 1
Pages: 14-14
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Reward processing alteration after bariatric surgery in obesity2017
Author(s)
Hirano Y, Matsumoto J, Kitahara A, Tokuyama H, Yamaga M, Kitamoto T, Matsumoto K, Masuda Y, Shimizu E, Yokote K
Organizer
The 24th European Congress on Obesity, Porto, Portugal
Related Report
Int'l Joint Research
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[Presentation] Altered serum level of matrix metalloproteinase-9 and its association with decision-making in eating disorders2016
Author(s)
Matsumoto J, Hirano Y, Hashimoto K, Ishima T, Sato Y, Yokote K, Murano S, Kimura H, Hosoda Y, Shimizu E, Iyo M and Nakazato M
Organizer
124th American Psychological Association Annual Convention
Place of Presentation
Denver, Colorado, USA
Year and Date
2016-08-04
Related Report
Int'l Joint Research
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[Presentation] Comparison in decision-making between bulimia nervosa, anorexia nervosa, and healthy women: influence of mood status and pathological eating concerns2015
Author(s)
Matsumoto J, Hirano Y, Numata N, Matzuzawa D, Murano S, Yokote K, Iyo M, Shimizu E and Nakazato M
Organizer
21st Eating Disorders Research Society Annual Meeting
Place of Presentation
Taormina, Sicily(Italy)
Year and Date
2015-09-17
Related Report
Int'l Joint Research
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